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ZNF281 zinc finger protein 281 [ Homo sapiens (human) ]

Gene ID: 23528, updated on 3-May-2020

Summary

Official Symbol
ZNF281provided by HGNC
Official Full Name
zinc finger protein 281provided by HGNC
Primary source
HGNC:HGNC:13075
See related
Ensembl:ENSG00000162702 MIM:618703
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GZP1; ZBP99; ZBP-99; ZNP-99
Expression
Ubiquitous expression in bone marrow (RPKM 10.1), appendix (RPKM 5.7) and 25 other tissues See more
Orthologs

Genomic context

See ZNF281 in Genome Data Viewer
Location:
1q32.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (200404951..200410036, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (200374075..200379186, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene CCNQ pseudogene 1 Neighboring gene long intergenic non-protein coding RNA 862 Neighboring gene uncharacterized LOC107985459 Neighboring gene kinesin family member 14

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12859, FLJ14378

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription corepressor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
embryonic body morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
stem cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 281
Names
GC-box-binding zinc finger protein 1
ZNP-99 transcription factor
transcription factor ZBP-99
zinc finger DNA-binding protein 99

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001281293.2NP_001268222.1  zinc finger protein 281 isoform 1

    See identical proteins and their annotated locations for NP_001268222.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AC104461, AJ132592, BP216938
    Consensus CDS
    CCDS1402.1
    UniProtKB/Swiss-Prot
    Q9Y2X9
    Related
    ENSP00000356322.1, ENST00000367353.2
    Conserved Domains (2) summary
    sd00017
    Location:263283
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:331356
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001281294.2NP_001268223.1  zinc finger protein 281 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the coding region compared to variant 1. The resulting protein (isoform 2) is missing an internal segment compared to isoform 1.
    Source sequence(s)
    AC104461, AK022921, AK094701, BC051905, BG611294, DB150929
    Consensus CDS
    CCDS60384.1
    UniProtKB/Swiss-Prot
    Q9Y2X9
    UniProtKB/TrEMBL
    B3KMX4
    Related
    ENSP00000356321.3, ENST00000367352.3
    Conserved Domains (3) summary
    sd00017
    Location:227247
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:225247
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:295320
    zf-H2C2_2; Zinc-finger double domain
  3. NM_012482.5NP_036614.1  zinc finger protein 281 isoform 1

    See identical proteins and their annotated locations for NP_036614.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript. Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AC104461, BC060820
    Consensus CDS
    CCDS1402.1
    UniProtKB/Swiss-Prot
    Q9Y2X9
    Related
    ENSP00000294740.2, ENST00000294740.3
    Conserved Domains (2) summary
    sd00017
    Location:263283
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:331356
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    200404951..200410036 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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