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ZNF281 zinc finger protein 281 [ Homo sapiens (human) ]

Gene ID: 23528, updated on 7-Jan-2024

Summary

Official Symbol
ZNF281provided by HGNC
Official Full Name
zinc finger protein 281provided by HGNC
Primary source
HGNC:HGNC:13075
See related
Ensembl:ENSG00000162702 MIM:618703; AllianceGenome:HGNC:13075
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GZP1; ZBP99; ZBP-99; ZNP-99
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of gene expression; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription, DNA-templated. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 10.1), appendix (RPKM 5.7) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF281 in Genome Data Viewer
Location:
1q32.1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (200404951..200410036, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (199661900..199740523, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (200374079..200379164, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904479 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2296 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1669 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:200271617-200271834 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:200321702-200322202 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:200322203-200322703 Neighboring gene long intergenic non-protein coding RNA 862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:200324513-200325012 Neighboring gene Sharpr-MPRA regulatory regions 7059 and 708 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:200341274-200341804 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:200343201-200344400 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2297 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:200378413-200378990 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:200378991-200379568 Neighboring gene NANOG hESC enhancer GRCh37_chr1:200379569-200380146 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:200380418-200381024 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:200385505-200386006 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:200386007-200386506 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:200388206-200388706 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:200388707-200389207 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:200396646-200397146 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:200397147-200397647 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2299 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2300 Neighboring gene uncharacterized LOC124900414 Neighboring gene uncharacterized LOC124904480 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1671 Neighboring gene uncharacterized LOC107985459

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ12859, FLJ14378

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 281
Names
GC-box-binding zinc finger protein 1
ZNP-99 transcription factor
transcription factor ZBP-99
zinc finger DNA-binding protein 99

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001281293.2NP_001268222.1  zinc finger protein 281 isoform 1

    See identical proteins and their annotated locations for NP_001268222.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AC104461, AJ132592, BP216938
    Consensus CDS
    CCDS1402.1
    UniProtKB/Swiss-Prot
    A6NF48, B3KMX2, Q5RKW5, Q9NY92, Q9Y2X9
    Related
    ENSP00000356322.1, ENST00000367353.2
    Conserved Domains (2) summary
    sd00017
    Location:263283
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:331356
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001281294.2NP_001268223.1  zinc finger protein 281 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the coding region compared to variant 1. The resulting protein (isoform 2) is missing an internal segment compared to isoform 1.
    Source sequence(s)
    AC104461, AK022921, AK094701, BC051905, BG611294, DB150929
    Consensus CDS
    CCDS60384.1
    UniProtKB/Swiss-Prot
    Q9Y2X9
    UniProtKB/TrEMBL
    B3KMX4
    Related
    ENSP00000356321.3, ENST00000367352.3
    Conserved Domains (3) summary
    sd00017
    Location:227247
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:225247
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:295320
    zf-H2C2_2; Zinc-finger double domain
  3. NM_012482.5NP_036614.1  zinc finger protein 281 isoform 1

    See identical proteins and their annotated locations for NP_036614.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript. Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AC104461, BC060820
    Consensus CDS
    CCDS1402.1
    UniProtKB/Swiss-Prot
    A6NF48, B3KMX2, Q5RKW5, Q9NY92, Q9Y2X9
    Related
    ENSP00000294740.2, ENST00000294740.3
    Conserved Domains (2) summary
    sd00017
    Location:263283
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:331356
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    200404951..200410036 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    199661900..199740523 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054335706.1XP_054191681.1  zinc finger protein 281 isoform X1

    UniProtKB/Swiss-Prot
    A6NF48, B3KMX2, Q5RKW5, Q9NY92, Q9Y2X9
  2. XM_054335707.1XP_054191682.1  zinc finger protein 281 isoform X1

    UniProtKB/Swiss-Prot
    A6NF48, B3KMX2, Q5RKW5, Q9NY92, Q9Y2X9
  3. XM_054335708.1XP_054191683.1  zinc finger protein 281 isoform X1

    UniProtKB/Swiss-Prot
    A6NF48, B3KMX2, Q5RKW5, Q9NY92, Q9Y2X9