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ANP32D acidic nuclear phosphoprotein 32 family member D [ Homo sapiens (human) ]

Gene ID: 23519, updated on 11-Jun-2021

Summary

Official Symbol
ANP32Dprovided by HGNC
Official Full Name
acidic nuclear phosphoprotein 32 family member Dprovided by HGNC
Primary source
HGNC:HGNC:16676
See related
Ensembl:ENSG00000139223 MIM:606878
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PP32R2
Summary
Phosphoprotein 32 (PP32) is a tumor suppressor that can inhibit several types of cancers, including prostate and breast cancers. The protein encoded by this gene is one of at least two proteins that are similar in amino acid sequence to PP32 and are part of the same acidic nuclear phosphoprotein gene family. However, unlike PP32, the encoded protein is tumorigenic. The tumor suppressor function of PP32 has been localized to a 25 amino acid region that is absent in the protein encoded by this gene. This gene does not contain introns. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See ANP32D in Genome Data Viewer
Location:
12q13.11
Exon count:
1
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (48472559..48473622)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (48866342..48867405)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene chromosome 12 open reading frame 54 Neighboring gene olfactory receptor family 8 subfamily S member 21 pseudogene Neighboring gene olfactory receptor family 8 subfamily T member 1 pseudogene Neighboring gene ribosomal protein S10 pseudogene 20 Neighboring gene olfactory receptor family 8 subfamily S member 1

Genomic regions, transcripts, and products

Phenotypes

Associated conditions

Description Tests
A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.
GeneReviews: Not available

General protein information

Preferred Names
acidic leucine-rich nuclear phosphoprotein 32 family member D
Names
acidic (leucine-rich) nuclear phosphoprotein 32 family, member D
acidic nuclear phosphoprotein 32D
phosphoprotein 32-related protein 2
pp32 related 2
tumorigenic protein pp32r2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012404.3NP_036536.2  acidic leucine-rich nuclear phosphoprotein 32 family member D

    See identical proteins and their annotated locations for NP_036536.2

    Status: REVIEWED

    Source sequence(s)
    AC089987
    Consensus CDS
    CCDS31788.1
    UniProtKB/Swiss-Prot
    O95626
    Related
    ENSP00000266594.2, ENST00000266594.4
    Conserved Domains (2) summary
    sd00035
    Location:90113
    LRR_NTF; leucine-rich repeat [structural motif]
    pfam12799
    Location:88130
    LRR_4; Leucine Rich repeats (2 copies)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    48472559..48473622
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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