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NUP188 nucleoporin 188 [ Homo sapiens (human) ]

Gene ID: 23511, updated on 21-Dec-2019

Summary

Official Symbol
NUP188provided by HGNC
Official Full Name
nucleoporin 188provided by HGNC
Primary source
HGNC:HGNC:17859
See related
Ensembl:ENSG00000095319 MIM:615587
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
hNup188; KIAA0169
Summary
The nuclear pore complex (NPC) is found on the nuclear envelope and forms a gateway that regulates the flow of proteins and RNAs between the cytoplasm and nucleoplasm. The NPC is comprised of approximately 30 distinct proteins collectively known as nucleoporins. Nucleoporins are pore-complex-specific glycoproteins which often have cytoplasmically oriented O-linked N-acetylglucosamine residues and numerous repeats of the pentapeptide sequence XFXFG. However, the nucleoporin protein encoded by this gene does not contain the typical FG repeat sequences found in most vertebrate nucleoporins. This nucleoporin is thought to form part of the scaffold for the central channel of the nuclear pore. [provided by RefSeq, Jan 2013]
Expression
Broad expression in testis (RPKM 47.7), skin (RPKM 10.9) and 23 other tissues See more
Orthologs

Genomic context

See NUP188 in Genome Data Viewer
Location:
9q34.11
Exon count:
44
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (128947699..129007096)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (131709972..131769375)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene phytanoyl-CoA dioxygenase domain containing 1 Neighboring gene dolichol kinase Neighboring gene uncharacterized LOC101929314 Neighboring gene SH3 domain containing GRB2 like, endophilin B2 Neighboring gene mitoguardin 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: PHYHD1

Homology

Clone Names

  • FLJ21639

Gene Ontology Provided by GOA

Function Evidence Code Pubs
structural constituent of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
intracellular transport of virus TAS
Traceable Author Statement
more info
 
mRNA export from nucleus TAS
Traceable Author Statement
more info
 
protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein sumoylation TAS
Traceable Author Statement
more info
 
regulation of cellular response to heat TAS
Traceable Author Statement
more info
 
regulation of gene silencing by miRNA TAS
Traceable Author Statement
more info
 
regulation of glycolytic process TAS
Traceable Author Statement
more info
 
tRNA export from nucleus TAS
Traceable Author Statement
more info
 
viral process TAS
Traceable Author Statement
more info
 
viral transcription TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
host cell IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
nuclear envelope TAS
Traceable Author Statement
more info
 
nuclear pore inner ring IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
nucleoporin NUP188 homolog
Names
nucleoporin 188kDa

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033111.1 RefSeqGene

    Range
    5007..64404
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_015354.3NP_056169.1  nucleoporin NUP188 homolog

    See identical proteins and their annotated locations for NP_056169.1

    Status: REVIEWED

    Source sequence(s)
    AA731883, D79991, HY094051
    Consensus CDS
    CCDS35156.1
    UniProtKB/Swiss-Prot
    Q5SRE5
    Related
    ENSP00000361658.2, ENST00000372577.2
    Conserved Domains (1) summary
    pfam10487
    Location:31941
    Nup188; Nucleoporin subcomplex protein binding to Pom34

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    128947699..129007096
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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