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Nup188 nucleoporin 188 [ Mus musculus (house mouse) ]

Gene ID: 227699, updated on 5-Feb-2023

Summary

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Official Symbol
Nup188provided by MGI
Official Full Name
nucleoporin 188provided by MGI
Primary source
MGI:MGI:2446190
See related
Ensembl:ENSMUSG00000052533 AllianceGenome:MGI:2446190
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to be a structural constituent of nuclear pore. Predicted to be involved in RNA export from nucleus and protein import into nucleus. Predicted to act upstream of or within mRNA transport and protein transport. Predicted to be located in nucleus. Predicted to be part of nuclear pore inner ring. Orthologous to human NUP188 (nucleoporin 188). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 50.6), thymus adult (RPKM 23.1) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Nup188 in Genome Data Viewer
Location:
2; 2 B
Exon count:
46
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (30176400..30234278)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (30286407..30344266)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene phytanoyl-CoA dioxygenase domain containing 1 Neighboring gene dolichol kinase Neighboring gene predicted gene, 39780 Neighboring gene SH3-domain GRB2-like endophilin B2 Neighboring gene mitoguardin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Peering through the pore: nuclear pore complex structure, assembly, and function. Suntharalingam M, et al. Dev Cell, 2003 Jun. PMID 12791264
  2. Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis. Chu CC, et al. Mol Immunol, 1998 Jun. PMID 9798653
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  5. Systematic analysis of human protein complexes identifies chromosome segregation proteins. Hutchins JR, et al. Science, 2010 Apr 30. PMID 20360068, Free PMC Article

See all (27) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0169

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleocytoplasmic transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in protein import into nucleus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear pore NAS
Non-traceable Author Statement
more info
 PubMed 
part_of nuclear pore inner ring IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nucleoporin NUP188; nucleoporin NUP188 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410239.1 → NP_001397168.1  nucleoporin NUP188 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL954388

  2. NM_001410240.1 → NP_001397169.1  nucleoporin NUP188 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL954388

  3. NM_001410241.1 → NP_001397170.1  nucleoporin NUP188 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL954388

  4. NM_001410242.1 → NP_001397171.1  nucleoporin NUP188 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL954388
    UniProtKB/TrEMBL
    A2AWI5

  5. NM_001410243.1 → NP_001397172.1  nucleoporin NUP188 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL954388
    UniProtKB/TrEMBL
    J3JSA4

  6. NM_198304.4 → NP_938046.2  nucleoporin NUP188 isoform 1

    See identical proteins and their annotated locations for NP_938046.2

    Status: VALIDATED

    Source sequence(s)
    AL954388
    Consensus CDS
    CCDS15878.1
    UniProtKB/Swiss-Prot
    Q6ZQH8, Q8R3F1
    Related
    ENSMUSP00000065836.6, ENSMUST00000064447.12
    Conserved Domains (1) summary
    pfam10487
    Location:31 → 941
    Nup188; Nucleoporin subcomplex protein binding to Pom34

RNA

  1. NR_156132.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL954388

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    30176400..30234278
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497934.3 → XP_006497997.1  nucleoporin NUP188 homolog isoform X2

    Conserved Domains (1) summary
    cl29134
    Location:1 → 747
    Nup192; Nuclear pore complex scaffold, nucleoporins 186/192/205

  2. XM_030249849.1 → XP_030105709.1  nucleoporin NUP188 homolog isoform X1

    Conserved Domains (1) summary
    pfam10487
    Location:4 → 828
    Nup188; Nucleoporin subcomplex protein binding to Pom34

  3. XM_030249850.1 → XP_030105710.1  nucleoporin NUP188 homolog isoform X2

    Conserved Domains (1) summary
    cl29134
    Location:1 → 747
    Nup192; Nuclear pore complex scaffold, nucleoporins 186/192/205
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZQH8.2 GenPept UniProtKB/Swiss-Prot:Q6ZQH8

Gene LinkOut

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