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TTC9 tetratricopeptide repeat domain 9 [ Homo sapiens (human) ]

Gene ID: 23508, updated on 11-Jun-2021

Summary

Official Symbol
TTC9provided by HGNC
Official Full Name
tetratricopeptide repeat domain 9provided by HGNC
Primary source
HGNC:HGNC:20267
See related
Ensembl:ENSG00000133985 MIM:610488
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TTC9A
Summary
This gene encodes a protein that contains three tetratricopeptide repeats. The gene has been shown to be hormonally regulated in breast cancer cells and may play a role in cancer cell invasion and metastasis. [provided by RefSeq, Mar 2009]
Expression
Biased expression in esophagus (RPKM 24.9), brain (RPKM 6.0) and 11 other tissues See more
Orthologs
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Genomic context

See TTC9 in Genome Data Viewer
Location:
14q24.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (70641916..70675366)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (71108633..71142083)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 6 Neighboring gene keratin 18 pseudogene 7 Neighboring gene RNA, 7SL, cytoplasmic 77, pseudogene Neighboring gene TTC9 divergent transcript Neighboring gene long intergenic non-protein coding RNA 1269 Neighboring gene mitogen-activated protein kinase kinase kinase 9 Neighboring gene MAP3K9 divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0227

General protein information

Preferred Names
tetratricopeptide repeat protein 9A
Names
TPR repeat protein 9A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012648.2 RefSeqGene

    Range
    5130..38580
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_015351.2NP_056166.1  tetratricopeptide repeat protein 9A

    See identical proteins and their annotated locations for NP_056166.1

    Status: REVIEWED

    Source sequence(s)
    AC004816, BX407741, D86980
    Consensus CDS
    CCDS45132.1
    UniProtKB/Swiss-Prot
    Q92623
    UniProtKB/TrEMBL
    A0A024R6B1
    Related
    ENSP00000256367.2, ENST00000256367.3
    Conserved Domains (3) summary
    sd00006
    Location:130159
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:165197
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:127195
    TPR_11; TPR repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    70641916..70675366
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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