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BICRAL BICRA like chromatin remodeling complex associated protein [ Homo sapiens (human) ]

Gene ID: 23506, updated on 5-Mar-2024

Summary

Official Symbol
BICRALprovided by HGNC
Official Full Name
BICRA like chromatin remodeling complex associated proteinprovided by HGNC
Primary source
HGNC:HGNC:21111
See related
Ensembl:ENSG00000112624 MIM:618502; AllianceGenome:HGNC:21111
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SMARCK2; GLTSCR1L; KIAA0240
Summary
Predicted to be involved in positive regulation of transcription, DNA-templated. Part of SWI/SNF complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 8.6), thyroid (RPKM 7.9) and 25 other tissues See more
Orthologs
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Genomic context

See BICRAL in Genome Data Viewer
Location:
6p21.1
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (42746339..42868556)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (42575724..42697274)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (42714725..42836294)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATPase H+ transporting V0 subunit c pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24566 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24567 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24568 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:42713934-42714897 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24569 Neighboring gene putative uncharacterized protein encoded by LINC00269 Neighboring gene tubulin folding cofactor C Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17207 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24570 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:42750599-42751288 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:42751289-42751978 Neighboring gene uncharacterized LOC401261 Neighboring gene MPRA-validated peak5810 silencer Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr6:42846366-42847323 and GRCh37_chr6:42847324-42848280 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24575 Neighboring gene ribosomal protein L7 like 1 Neighboring gene chromosome 6 open reading frame 226

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA0240, DKFZp686P0250

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of GBAF complex NAS
Non-traceable Author Statement
more info
PubMed 
part_of SWI/SNF complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of SWI/SNF complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of chromatin NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
BRD4-interacting chromatin-remodeling complex-associated protein-like
Names
BRD4 interacting chromatin remodeling complex associated protein like
BRD4 interacting chromatin remodelling complex associated protein like
GLTSCR1 like
glioma tumor suppressor candidate region gene 1 protein-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_054763.1 RefSeqGene

    Range
    40095..126599
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001318819.2NP_001305748.1  BRD4-interacting chromatin-remodeling complex-associated protein-like

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL353716, AW168030, D87077
    Consensus CDS
    CCDS34451.1
    UniProtKB/Swiss-Prot
    A1L3W2, Q5TFZ3, Q6AI39, Q92514
    Conserved Domains (1) summary
    pfam15249
    Location:711811
    GLTSCR1; Conserved region of unknown function on GLTSCR protein
  2. NM_001393499.1NP_001380428.1  BRD4-interacting chromatin-remodeling complex-associated protein-like

    Status: VALIDATED

    Source sequence(s)
    AL035587, AL353716
    Consensus CDS
    CCDS34451.1
    UniProtKB/Swiss-Prot
    A1L3W2, Q5TFZ3, Q6AI39, Q92514
    Related
    ENSP00000313933.4, ENST00000314073.10
    Conserved Domains (1) summary
    pfam15249
    Location:711811
    GLTSCR1; Conserved region of unknown function on GLTSCR protein
  3. NM_015349.3NP_056164.1  BRD4-interacting chromatin-remodeling complex-associated protein-like

    See identical proteins and their annotated locations for NP_056164.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK093526, AL833540, AW168030, BC015724, BC047630
    Consensus CDS
    CCDS34451.1
    UniProtKB/Swiss-Prot
    A1L3W2, Q5TFZ3, Q6AI39, Q92514
    Related
    ENSP00000377723.1, ENST00000394168.1
    Conserved Domains (1) summary
    pfam15249
    Location:711811
    GLTSCR1; Conserved region of unknown function on GLTSCR protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    42746339..42868556
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047418544.1XP_047274500.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X2

  2. XM_047418547.1XP_047274503.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X3

  3. XM_047418542.1XP_047274498.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X2

  4. XM_047418545.1XP_047274501.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X2

  5. XM_047418543.1XP_047274499.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X2

  6. XM_024446390.2XP_024302158.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X1

    UniProtKB/Swiss-Prot
    A1L3W2, Q5TFZ3, Q6AI39, Q92514
    Conserved Domains (1) summary
    pfam15249
    Location:711811
    GLTSCR1; Conserved region of unknown function on GLTSCR protein

RNA

  1. XR_007059228.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    42575724..42697274
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054354967.1XP_054210942.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X1

    UniProtKB/Swiss-Prot
    A1L3W2, Q5TFZ3, Q6AI39, Q92514
  2. XM_054354961.1XP_054210936.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X1

    UniProtKB/Swiss-Prot
    A1L3W2, Q5TFZ3, Q6AI39, Q92514
  3. XM_054354962.1XP_054210937.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X1

    UniProtKB/Swiss-Prot
    A1L3W2, Q5TFZ3, Q6AI39, Q92514
  4. XM_054354968.1XP_054210943.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X1

    UniProtKB/Swiss-Prot
    A1L3W2, Q5TFZ3, Q6AI39, Q92514
  5. XM_054354964.1XP_054210939.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X1

    UniProtKB/Swiss-Prot
    A1L3W2, Q5TFZ3, Q6AI39, Q92514
  6. XM_054354963.1XP_054210938.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X1

    UniProtKB/Swiss-Prot
    A1L3W2, Q5TFZ3, Q6AI39, Q92514
  7. XM_054354965.1XP_054210940.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X1

    UniProtKB/Swiss-Prot
    A1L3W2, Q5TFZ3, Q6AI39, Q92514
  8. XM_054354966.1XP_054210941.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X1

    UniProtKB/Swiss-Prot
    A1L3W2, Q5TFZ3, Q6AI39, Q92514

RNA

  1. XR_008487286.1 RNA Sequence