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Nup133 nucleoporin 133 [ Mus musculus (house mouse) ]

Gene ID: 234865, updated on 12-May-2024

Summary

Official Symbol
Nup133provided by MGI
Official Full Name
nucleoporin 133provided by MGI
Primary source
MGI:MGI:2442620
See related
Ensembl:ENSMUSG00000039509 AllianceGenome:MGI:2442620
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mermaid
Summary
Predicted to be a structural constituent of nuclear pore. Acts upstream of or within nervous system development; paraxial mesoderm development; and somite development. Part of nuclear pore. Is expressed in several structures, including brain; epiblast; male reproductive gland or organ; neural tube; and paraxial mesenchyme. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome and nephrotic syndrome type 18. Orthologous to human NUP133 (nucleoporin 133). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 8.3), liver E14.5 (RPKM 8.2) and 28 other tissues See more
Orthologs
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Genomic context

See Nup133 in Genome Data Viewer
Location:
8 E2; 8 72.27 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (124623862..124676019, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (123897114..123949265, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53468 Neighboring gene predicted gene, 29773 Neighboring gene actin alpha 1, skeletal muscle Neighboring gene ATP-binding cassette, sub-family B member 10 Neighboring gene predicted gene, 53469 Neighboring gene STARR-seq mESC enhancer starr_22990 Neighboring gene TATA-box binding protein associated factor 5 like Neighboring gene ribosomal protein L7A pseudogene

Genomic regions, transcripts, and products

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
 
enables structural constituent of nuclear pore ISO
Inferred from Sequence Orthology
more info
 
enables structural constituent of nuclear pore ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
involved_in mRNA export from nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in mRNA export from nucleus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
acts_upstream_of_or_within mRNA transport IEA
Inferred from Electronic Annotation
more info
 
involved_in nephron development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neural tube development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nuclear pore organization ISO
Inferred from Sequence Orthology
more info
 
involved_in nucleocytoplasmic transport NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within paraxial mesoderm development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in poly(A)+ mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within somite development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with kinetochore ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
part_of nuclear pore IDA
Inferred from Direct Assay
more info
PubMed 
part_of nuclear pore ISO
Inferred from Sequence Orthology
more info
 
part_of nuclear pore ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
part_of nuclear pore NAS
Non-traceable Author Statement
more info
PubMed 
part_of nuclear pore outer ring IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of nuclear pore outer ring ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
nuclear pore complex protein Nup133
Names
133 kDa nucleoporin
nucleoporin Nup133

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172288.3NP_758492.2  nuclear pore complex protein Nup133

    See identical proteins and their annotated locations for NP_758492.2

    Status: VALIDATED

    Source sequence(s)
    AC123825, AC147266
    Consensus CDS
    CCDS22765.1
    UniProtKB/Swiss-Prot
    E9QLJ8, Q8R0G9
    UniProtKB/TrEMBL
    Q8CDZ5
    Related
    ENSMUSP00000048084.8, ENSMUST00000044795.8
    Conserved Domains (1) summary
    pfam03177
    Location:5941097
    Nucleoporin_C; Non-repetitive/WGA-negative nucleoporin C-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    124623862..124676019 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530964.5XP_006531027.1  nuclear pore complex protein Nup133 isoform X1

    Conserved Domains (1) summary
    pfam03177
    Location:184454
    Nucleoporin_C; Non-repetitive/WGA-negative nucleoporin C-terminal