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NUP133 nucleoporin 133 [ Homo sapiens (human) ]

Gene ID: 55746, updated on 3-May-2020

Summary

Official Symbol
NUP133provided by HGNC
Official Full Name
nucleoporin 133provided by HGNC
Primary source
HGNC:HGNC:18016
See related
Ensembl:ENSG00000069248 MIM:607613
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GAMOS8; NPHS18; hNUP133
Summary
The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. The nucleoporin protein encoded by this gene displays evolutionarily conserved interactions with other nucleoporins. This protein, which localizes to both sides of the nuclear pore complex at interphase, remains associated with the complex during mitosis and is targeted at early stages to the reforming nuclear envelope. This protein also localizes to kinetochores of mitotic cells. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 11.8), brain (RPKM 11.8) and 25 other tissues See more
Orthologs

Genomic context

See NUP133 in Genome Data Viewer
Location:
1q42.13
Exon count:
26
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (229440259..229508342, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (229577044..229644088, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 11409 Neighboring gene actin alpha 1, skeletal muscle Neighboring gene uncharacterized LOC101927478 Neighboring gene ATP binding cassette subfamily B member 10 Neighboring gene RNA, U4 small nuclear 21, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of nucleoporin 133kDa (NUP133) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Mermaid (NUP133) shares glycan specificity with DC-SIGN and inhibits the interaction between DC-SIGN and HIV-1 gp120 PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with NUP133 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10814, MGC21133

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of nuclear pore IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
RNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular transport of virus TAS
Traceable Author Statement
more info
 
mRNA export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
mRNA export from nucleus TAS
Traceable Author Statement
more info
 
nephron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
neural tube development IEA
Inferred from Electronic Annotation
more info
 
neurogenesis IEA
Inferred from Electronic Annotation
more info
 
nuclear pore distribution IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear pore organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
paraxial mesoderm development IEA
Inferred from Electronic Annotation
more info
 
protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein sumoylation TAS
Traceable Author Statement
more info
 
regulation of cellular response to heat TAS
Traceable Author Statement
more info
 
regulation of gene silencing by miRNA TAS
Traceable Author Statement
more info
 
regulation of glycolytic process TAS
Traceable Author Statement
more info
 
regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
somite development IEA
Inferred from Electronic Annotation
more info
 
tRNA export from nucleus TAS
Traceable Author Statement
more info
 
transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
viral process TAS
Traceable Author Statement
more info
 
viral transcription TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
colocalizes_with condensed chromosome kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with condensed chromosome kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with condensed chromosome outer kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
host cell IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
nuclear envelope TAS
Traceable Author Statement
more info
 
nuclear membrane IDA
Inferred from Direct Assay
more info
 
nuclear pore IDA
Inferred from Direct Assay
more info
PubMed 
nuclear pore outer ring IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear pore outer ring IDA
Inferred from Direct Assay
more info
PubMed 
nuclear pore outer ring NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
nuclear pore complex protein Nup133
Names
133 kDa nucleoporin
nucleoporin 133kD
nucleoporin 133kDa
nucleoporin Nup133

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011969.1 RefSeqGene

    Range
    5001..73083
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_018230.3NP_060700.2  nuclear pore complex protein Nup133

    See identical proteins and their annotated locations for NP_060700.2

    Status: REVIEWED

    Source sequence(s)
    AL121990, AL139252, AL160004
    Consensus CDS
    CCDS1579.1
    UniProtKB/Swiss-Prot
    Q8WUM0
    Related
    ENSP00000261396.3, ENST00000261396.6
    Conserved Domains (1) summary
    pfam03177
    Location:5951098
    Nucleoporin_C; Non-repetitive/WGA-negative nucleoporin C-terminal

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    229440259..229508342 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001737299.2 RNA Sequence

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