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NUP133 nucleoporin 133 [ Homo sapiens (human) ]

Gene ID: 55746, updated on 17-Jun-2024

Summary

Official Symbol
NUP133provided by HGNC
Official Full Name
nucleoporin 133provided by HGNC
Primary source
HGNC:HGNC:18016
See related
Ensembl:ENSG00000069248 MIM:607613; AllianceGenome:HGNC:18016
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GAMOS8; NPHS18; hNUP133
Summary
The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. The nucleoporin protein encoded by this gene displays evolutionarily conserved interactions with other nucleoporins. This protein, which localizes to both sides of the nuclear pore complex at interphase, remains associated with the complex during mitosis and is targeted at early stages to the reforming nuclear envelope. This protein also localizes to kinetochores of mitotic cells. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 11.8), brain (RPKM 11.8) and 25 other tissues See more
Orthologs
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Genomic context

See NUP133 in Genome Data Viewer
Location:
1q42.13
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (229440259..229508341, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (228818956..228887101, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (229576006..229644088, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904541 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:229550455-229550955 Neighboring gene RN7SK pseudogene 276 Neighboring gene NANOG hESC enhancer GRCh37_chr1:229552218-229552719 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:229553351-229554106 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:229554107-229554860 Neighboring gene Sharpr-MPRA regulatory region 11409 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:229566843-229567462 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:229567463-229568084 Neighboring gene Sharpr-MPRA regulatory region 2214 Neighboring gene MPRA-validated peak754 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1929 Neighboring gene NANOG hESC enhancer GRCh37_chr1:229576278-229576818 Neighboring gene actin alpha 1, skeletal muscle Neighboring gene Sharpr-MPRA regulatory region 12306 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1930 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2702 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1931 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2703 Neighboring gene Sharpr-MPRA regulatory region 12340 Neighboring gene NUP133 divergent transcript Neighboring gene ATP binding cassette subfamily B member 10 Neighboring gene RNA, U4 small nuclear 21, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of nucleoporin 133kDa (NUP133) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Mermaid (NUP133) shares glycan specificity with DC-SIGN and inhibits the interaction between DC-SIGN and HIV-1 gp120 PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with NUP133 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ10814, MGC21133

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
 
enables structural constituent of nuclear pore IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in mRNA export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nephron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neural tube development IEA
Inferred from Electronic Annotation
more info
 
involved_in neurogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in nuclear pore organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nucleocytoplasmic transport NAS
Non-traceable Author Statement
more info
PubMed 
involved_in paraxial mesoderm development IEA
Inferred from Electronic Annotation
more info
 
involved_in poly(A)+ mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in somite development IEA
Inferred from Electronic Annotation
more info
 
involved_in transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
colocalizes_with kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane HDA PubMed 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear envelope TAS
Traceable Author Statement
more info
 
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
 
part_of nuclear pore IDA
Inferred from Direct Assay
more info
PubMed 
part_of nuclear pore NAS
Non-traceable Author Statement
more info
PubMed 
part_of nuclear pore outer ring IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of nuclear pore outer ring IDA
Inferred from Direct Assay
more info
PubMed 
part_of nuclear pore outer ring NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
nuclear pore complex protein Nup133
Names
133 kDa nucleoporin
nucleoporin 133kD
nucleoporin 133kDa
nucleoporin Nup133

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011969.1 RefSeqGene

    Range
    5001..73083
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_018230.3NP_060700.2  nuclear pore complex protein Nup133

    See identical proteins and their annotated locations for NP_060700.2

    Status: REVIEWED

    Source sequence(s)
    AL121990, AL139252, AL160004
    Consensus CDS
    CCDS1579.1
    UniProtKB/Swiss-Prot
    B2RAZ8, Q5T8N0, Q8WUM0, Q9H9W2, Q9NV71, Q9NVC4
    UniProtKB/TrEMBL
    B4E206
    Related
    ENSP00000261396.3, ENST00000261396.6
    Conserved Domains (1) summary
    pfam03177
    Location:5951098
    Nucleoporin_C; Non-repetitive/WGA-negative nucleoporin C-terminal

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    229440259..229508341 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047424979.1XP_047280935.1  nuclear pore complex protein Nup133 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    228818956..228887101 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054337617.1XP_054193592.1  nuclear pore complex protein Nup133 isoform X1