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SEC61G SEC61 translocon subunit gamma [ Homo sapiens (human) ]

Gene ID: 23480, updated on 3-Oct-2020

Summary

Official Symbol
SEC61Gprovided by HGNC
Official Full Name
SEC61 translocon subunit gammaprovided by HGNC
Primary source
HGNC:HGNC:18277
See related
Ensembl:ENSG00000132432 MIM:609215
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SSS1
Summary
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the gamma-subunit protein. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in colon (RPKM 71.5), prostate (RPKM 56.4) and 25 other tissues See more
Orthologs

Genomic context

See SEC61G in Genome Data Viewer
Location:
7p11.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (54752253..54759211, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (54819940..54826939, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 1125, pseudogene Neighboring gene ribosomal protein L31 pseudogene 35 Neighboring gene SEC61G divergent transcript Neighboring gene Rho GTPase activating protein 5 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
Genetic Loci Associated with Circulating Levels of Very Long-Chain Saturated Fatty Acids.
GeneReviews: Not available
GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of Sec61 gamma subunit (SEC61G) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
P-P-bond-hydrolysis-driven protein transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
posttranslational protein targeting to membrane, translocation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein targeting to ER ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
Ssh1 translocon complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein transport protein Sec61 subunit gamma
Names
SEC61 translocon gamma subunit
Sec61 gamma subunit
protein transport protein SEC61 gamma subunit

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012456.2NP_001012474.1  protein transport protein Sec61 subunit gamma

    See identical proteins and their annotated locations for NP_001012474.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF086539, BU932672, CD385140
    Consensus CDS
    CCDS5513.1
    UniProtKB/Swiss-Prot
    P60059
    UniProtKB/TrEMBL
    A0A024QYZ0
    Related
    ENSP00000378906.3, ENST00000395535.7
    Conserved Domains (1) summary
    cl00481
    Location:1268
    SecE; SecE/Sec61-gamma subunits of protein translocation complex
  2. NM_014302.4NP_055117.1  protein transport protein Sec61 subunit gamma

    See identical proteins and their annotated locations for NP_055117.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF086539, BU932672, CD385140
    Consensus CDS
    CCDS5513.1
    UniProtKB/Swiss-Prot
    P60059
    UniProtKB/TrEMBL
    A0A024QYZ0
    Related
    ENSP00000341538.4, ENST00000352861.9
    Conserved Domains (1) summary
    cl00481
    Location:1268
    SecE; SecE/Sec61-gamma subunits of protein translocation complex

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    54752253..54759211 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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