Gatad2a GATA zinc finger domain containing 2A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gatad2aprovided by MGI
Official Full Name: GATA zinc finger domain containing 2Aprovided by MGI
Primary source: MGI:MGI:2384585
See related: Ensembl:ENSMUSG00000036180 AllianceGenome:MGI:2384585
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1110066C11Rik
Summary: Predicted to enable protein-macromolecule adaptor activity. Acts upstream of or within several processes, including blood vessel development; chordate embryonic development; and embryonic body morphogenesis. Predicted to be located in nucleoplasm. Predicted to be part of NuRD complex. Is expressed in several structures, including brain and enteric nervous system. Orthologous to human GATAD2A (GATA zinc finger domain containing 2A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 31.4), ovary adult (RPKM 26.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 B3.3; 8 34.06 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (70359719..70450093, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (69907069..69996402, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

It validates a distinct molecular axis, Gatad2a-Chd4-Mbd3, within Mbd3/NuRD as being critical for blocking reestablishment of naive pluripotency and further highlight signaling-dependent and post-translational modifications of Mbd3/NuRD that influence its interactions and assembly.
Title: Neutralizing Gatad2a-Chd4-Mbd3/NuRD Complex Facilitates Deterministic Induction of Naive Pluripotency.
our data demonstrate that p66a may physically interact with STAT3 to suppress its activity through posttranslational modification, which reveals a novel regulatory mechanism controlling STAT3 activation during myeloid cell differentiation.
Title: Epigenetic Component p66a Modulates Myeloid-Derived Suppressor Cells by Modifying STAT3.
mp66alpha is an essential gene, required for early mouse development; the lethal phenotype supports a role in execution of methylated DNA silencing
Title: Mutants in the mouse NuRD/Mi2 component P66alpha are embryonic lethal.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH137062 (e-PCR)
- UniSTS:219151

RH126607 (e-PCR)
- UniSTS:209719

RH126832 (e-PCR)
- UniSTS:208290

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within anterior neuropore closure	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic body morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neural fold formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell fate specification	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of stem cell differentiation	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of NuRD complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NuRD complex	ISO Inferred from Sequence Orthology more info
part_of NuRD complex	ISS Inferred from Sequence or Structural Similarity more info
part_of NuRD complex	NAS Non-traceable Author Statement more info	PubMed
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: transcriptional repressor p66 alpha

Names: GATA zinc finger domain-containing protein 2A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113346.1 → NP_001106817.1 transcriptional repressor p66 alpha isoform b

See identical proteins and their annotated locations for NP_001106817.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.

Source sequence(s)

AC158564, BQ571528, CF726663, CJ166913, CN666280, CV562594, DV651557

Consensus CDS

CCDS52567.1

UniProtKB/Swiss-Prot

Q8BTQ2, Q8CHY6, Q8VEC9

UniProtKB/TrEMBL

A0A1I7Q4G8

Related

ENSMUSP00000112164.3, ENSMUST00000116463.4

Conserved Domains (2) summary

pfam16563
Location:133 → 169

P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

cl29608
Location:416 → 448

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
NM_001286450.1 → NP_001273379.1 transcriptional repressor p66 alpha isoform d

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses several alternate splice sites, one of which results in a frameshift, compared to variant 1. This results in a longer protein (isoform d) with a distinct C-terminus, compared to isoform a.

Source sequence(s)

AK083473, AK148968, AK160058

Related

ENSMUSP00000137386.3, ENSMUST00000177851.9

Conserved Domains (2) summary

pfam16563
Location:133 → 169

P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

cl00158
Location:419 → 452

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
NM_145596.4 → NP_663571.2 transcriptional repressor p66 alpha isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. It encodes isoform a.

Source sequence(s)

AK083473, AK148968, AK160058, CA317226

Consensus CDS

CCDS22355.1

UniProtKB/TrEMBL

A0A1I7Q4G8, E9QMN5

Related

ENSMUSP00000070229.5, ENSMUST00000065169.12

Conserved Domains (2) summary

pfam16563
Location:133 → 169

P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

cl29608
Location:417 → 450

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

70359719..70450093 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017312722.3 → XP_017168211.1 transcriptional repressor p66 alpha isoform X16

UniProtKB/TrEMBL

A0A1I7Q4G8

Conserved Domains (2) summary

pfam16563
Location:133 → 169

P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

cl29608
Location:415 → 448

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_030243469.2 → XP_030099329.1 transcriptional repressor p66 alpha isoform X8

UniProtKB/TrEMBL

A0A1I7Q4G8

Conserved Domains (2) summary

pfam16563
Location:133 → 169

P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

cl29608
Location:415 → 448

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_017312721.3 → XP_017168210.1 transcriptional repressor p66 alpha isoform X14

UniProtKB/TrEMBL

A0A1I7Q4G8

Conserved Domains (2) summary

pfam16563
Location:133 → 169

P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

cl29608
Location:416 → 448

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_017312720.3 → XP_017168209.1 transcriptional repressor p66 alpha isoform X13

UniProtKB/TrEMBL

A0A1I7Q4G8

Conserved Domains (2) summary

pfam16563
Location:133 → 169

P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

cl29608
Location:417 → 449

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_030243470.2 → XP_030099330.1 transcriptional repressor p66 alpha isoform X10

UniProtKB/TrEMBL

A0A1I7Q4G8

Conserved Domains (2) summary

pfam16563
Location:133 → 169

P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

cl29608
Location:419 → 452

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_030243471.2 → XP_030099331.1 transcriptional repressor p66 alpha isoform X11

UniProtKB/TrEMBL

A0A1I7Q4G8

Conserved Domains (2) summary

pfam16563
Location:133 → 169

P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

cl29608
Location:419 → 451

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_006509636.5 → XP_006509699.1 transcriptional repressor p66 alpha isoform X3

UniProtKB/TrEMBL

A0A1I7Q4G8

Conserved Domains (2) summary

pfam16563
Location:133 → 169

P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

cl29608
Location:419 → 451

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_006509638.5 → XP_006509701.1 transcriptional repressor p66 alpha isoform X9

UniProtKB/TrEMBL

A0A1I7Q4G8

Conserved Domains (2) summary

pfam16563
Location:133 → 169

P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

cl29608
Location:420 → 453

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_036153943.1 → XP_036009836.1 transcriptional repressor p66 alpha isoform X15

UniProtKB/TrEMBL

A0A1I7Q4G8

Conserved Domains (2) summary

pfam16563
Location:133 → 169

P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

cl29608
Location:416 → 449

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_017312719.3 → XP_017168208.1 transcriptional repressor p66 alpha isoform X7

UniProtKB/TrEMBL

A0A1I7Q4G8

Conserved Domains (2) summary

pfam16563
Location:133 → 169

P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

cl29608
Location:416 → 448

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_030243475.2 → XP_030099335.1 transcriptional repressor p66 alpha isoform X15

UniProtKB/TrEMBL

A0A1I7Q4G8

Conserved Domains (2) summary

pfam16563
Location:133 → 169

P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

cl29608
Location:416 → 449

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_036153940.1 → XP_036009833.1 transcriptional repressor p66 alpha isoform X9

UniProtKB/TrEMBL

A0A1I7Q4G8

Conserved Domains (2) summary

pfam16563
Location:133 → 169

P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

cl29608
Location:420 → 453

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_030243474.2 → XP_030099334.1 transcriptional repressor p66 alpha isoform X14

UniProtKB/TrEMBL

A0A1I7Q4G8

Conserved Domains (2) summary

pfam16563
Location:133 → 169

P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

cl29608
Location:416 → 448

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_036153944.1 → XP_036009837.1 transcriptional repressor p66 alpha isoform X16

UniProtKB/TrEMBL

A0A1I7Q4G8

Conserved Domains (2) summary

pfam16563
Location:133 → 169

P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

cl29608
Location:415 → 448

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_036153938.1 → XP_036009831.1 transcriptional repressor p66 alpha isoform X8

UniProtKB/TrEMBL

A0A1I7Q4G8

Conserved Domains (2) summary

pfam16563
Location:133 → 169

P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

cl29608
Location:415 → 448

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_030243472.2 → XP_030099332.1 transcriptional repressor p66 alpha isoform X13

UniProtKB/TrEMBL

A0A1I7Q4G8

Conserved Domains (2) summary

pfam16563
Location:133 → 169

P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

cl29608
Location:417 → 449

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_036153942.1 → XP_036009835.1 transcriptional repressor p66 alpha isoform X12

UniProtKB/TrEMBL

A0A1I7Q4G8

Conserved Domains (2) summary

pfam16563
Location:133 → 169

P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

cl29608
Location:418 → 451

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_030243463.2 → XP_030099323.1 transcriptional repressor p66 alpha isoform X4

UniProtKB/TrEMBL

A0A1I7Q4G8

Conserved Domains (2) summary

pfam16563
Location:133 → 169

P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

cl29608
Location:418 → 450

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_036153941.1 → XP_036009834.1 transcriptional repressor p66 alpha isoform X10

UniProtKB/TrEMBL

A0A1I7Q4G8

Conserved Domains (2) summary

pfam16563
Location:133 → 169

P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

cl29608
Location:419 → 452

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_036153939.1 → XP_036009832.1 transcriptional repressor p66 alpha isoform X9

UniProtKB/TrEMBL

A0A1I7Q4G8

Conserved Domains (2) summary

pfam16563
Location:133 → 169

P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

cl29608
Location:420 → 453

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_030243473.2 → XP_030099333.1 transcriptional repressor p66 alpha isoform X14

UniProtKB/TrEMBL

A0A1I7Q4G8

Conserved Domains (2) summary

pfam16563
Location:133 → 169

P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

cl29608
Location:416 → 448

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_017312716.3 → XP_017168205.1 transcriptional repressor p66 alpha isoform X1

UniProtKB/TrEMBL

A0A1I7Q4G8

Conserved Domains (2) summary

pfam16563
Location:133 → 169

P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

cl29608
Location:420 → 452

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_011242295.4 → XP_011240597.1 transcriptional repressor p66 alpha isoform X6

See identical proteins and their annotated locations for XP_011240597.1

UniProtKB/Swiss-Prot

Q8BTQ2, Q8CHY6, Q8VEC9

UniProtKB/TrEMBL

A0A1I7Q4G8

Related

ENSMUSP00000148474.2, ENSMUST00000212478.2

Conserved Domains (2) summary

pfam16563
Location:133 → 169

P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

cl29608
Location:416 → 448

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_017312718.3 → XP_017168207.1 transcriptional repressor p66 alpha isoform X2

UniProtKB/TrEMBL

A0A1I7Q4G8

Conserved Domains (2) summary

pfam16563
Location:133 → 169

P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

cl29608
Location:419 → 452

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_017312714.3 → XP_017168203.1 transcriptional repressor p66 alpha isoform X1

UniProtKB/TrEMBL

A0A1I7Q4G8

Conserved Domains (2) summary

pfam16563
Location:133 → 169

P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

cl29608
Location:420 → 452

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_030243466.2 → XP_030099326.1 transcriptional repressor p66 alpha isoform X6

UniProtKB/Swiss-Prot

Q8BTQ2, Q8CHY6, Q8VEC9

UniProtKB/TrEMBL

A0A1I7Q4G8

Conserved Domains (2) summary

pfam16563
Location:133 → 169

P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

cl29608
Location:416 → 448

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_036153937.1 → XP_036009830.1 transcriptional repressor p66 alpha isoform X5

UniProtKB/TrEMBL

A0A1I7Q4G8, E9QMN5

Conserved Domains (2) summary

pfam16563
Location:133 → 169

P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

cl29608
Location:417 → 450

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_030243462.2 → XP_030099322.1 transcriptional repressor p66 alpha isoform X2

UniProtKB/TrEMBL

A0A1I7Q4G8

Conserved Domains (2) summary

pfam16563
Location:133 → 169

P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

cl29608
Location:419 → 452

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_017312715.3 → XP_017168204.1 transcriptional repressor p66 alpha isoform X1

UniProtKB/TrEMBL

A0A1I7Q4G8

Conserved Domains (2) summary

pfam16563
Location:133 → 169

P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

cl29608
Location:420 → 452

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_030243464.2 → XP_030099324.1 transcriptional repressor p66 alpha isoform X5

UniProtKB/TrEMBL

A0A1I7Q4G8, E9QMN5

Conserved Domains (2) summary

pfam16563
Location:133 → 169

P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

cl29608
Location:417 → 450

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_036153934.1 → XP_036009827.1 transcriptional repressor p66 alpha isoform X2

UniProtKB/TrEMBL

A0A1I7Q4G8

Conserved Domains (2) summary

pfam16563
Location:133 → 169

P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

cl29608
Location:419 → 452

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_017312717.3 → XP_017168206.1 transcriptional repressor p66 alpha isoform X1

UniProtKB/TrEMBL

A0A1I7Q4G8

Conserved Domains (2) summary

pfam16563
Location:133 → 169

P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

cl29608
Location:420 → 452

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_036153935.1 → XP_036009828.1 transcriptional repressor p66 alpha isoform X5

UniProtKB/TrEMBL

A0A1I7Q4G8, E9QMN5

Conserved Domains (2) summary

pfam16563
Location:133 → 169

P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

cl29608
Location:417 → 450

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_030243467.2 → XP_030099327.1 transcriptional repressor p66 alpha isoform X6

UniProtKB/Swiss-Prot

Q8BTQ2, Q8CHY6, Q8VEC9

UniProtKB/TrEMBL

A0A1I7Q4G8

Conserved Domains (2) summary

pfam16563
Location:133 → 169

P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

cl29608
Location:416 → 448

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_030243465.2 → XP_030099325.1 transcriptional repressor p66 alpha isoform X6

UniProtKB/Swiss-Prot

Q8BTQ2, Q8CHY6, Q8VEC9

UniProtKB/TrEMBL

A0A1I7Q4G8

Conserved Domains (2) summary

pfam16563
Location:133 → 169

P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

cl29608
Location:416 → 448

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_030243460.2 → XP_030099320.1 transcriptional repressor p66 alpha isoform X1

UniProtKB/TrEMBL

A0A1I7Q4G8

Conserved Domains (2) summary

pfam16563
Location:133 → 169

P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

cl29608
Location:420 → 452

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001113345.1: Suppressed sequence

Description

NM_001113345.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.