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GATAD2A GATA zinc finger domain containing 2A [ Homo sapiens (human) ]

Gene ID: 54815, updated on 5-Jul-2020

Summary

Official Symbol
GATAD2Aprovided by HGNC
Official Full Name
GATA zinc finger domain containing 2Aprovided by HGNC
Primary source
HGNC:HGNC:29989
See related
Ensembl:ENSG00000167491 MIM:614997
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p66alpha
Expression
Ubiquitous expression in testis (RPKM 18.1), spleen (RPKM 10.8) and 25 other tissues See more
Orthologs

Genomic context

See GATAD2A in Genome Data Viewer
Location:
19p13.11
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (19385803..19508932)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (19496642..19619741)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene SURP and G-patch domain containing 1 Neighboring gene MAU2 sister chromatid cohesion factor Neighboring gene microRNA 640 Neighboring gene Sharpr-MPRA regulatory region 5941 Neighboring gene NADH:ubiquinone oxidoreductase subunit A13 Neighboring gene testis specific serine kinase 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
NHGRI GWA Catalog
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of GATA zinc finger domain containing 2A (GATAD2A) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat Methyl-CpG-binding proteins MBD2 and p66alpha are identified to interact with HIV-1 Tat in Jurkat cell PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20085, FLJ21017

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding, bridging IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA methylation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
NuRD complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NuRD complex IDA
Inferred from Direct Assay
more info
PubMed 
nuclear speck IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transcriptional repressor p66-alpha
Names
GATA zinc finger domain-containing protein 2A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300946.3NP_001287875.1  transcriptional repressor p66-alpha isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1. Variants 1 and 4-20 all encode the same isoform (1).
    Source sequence(s)
    AC003030, AC011448, KC877710
    Consensus CDS
    CCDS77270.1
    UniProtKB/Swiss-Prot
    Q86YP4
    UniProtKB/TrEMBL
    A0A024R7M6
    Related
    ENSP00000384899.2, ENST00000404158.5
    Conserved Domains (2) summary
    pfam00320
    Location:418452
    GATA; GATA zinc finger
    pfam16563
    Location:137173
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
  2. NM_001359631.2NP_001346560.1  transcriptional repressor p66-alpha isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes isoform 3. Variants 3 and 26-28 all encode the same isoform (3).
    Source sequence(s)
    AC003030, AC011448
    Conserved Domains (3) summary
    pfam00320
    Location:418452
    GATA; GATA zinc finger
    pfam11221
    Location:98167
    Med21; Subunit 21 of Mediator complex
    pfam16563
    Location:137173
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
  3. NM_001384511.1NP_001371440.1  transcriptional repressor p66-alpha isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 and 4-20 all encode the same isoform (1).
    Source sequence(s)
    AC003030, AC011448, KC877710
  4. NM_001384512.1NP_001371441.1  transcriptional repressor p66-alpha isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1 and 4-20 all encode the same isoform (1).
    Source sequence(s)
    AC003030, AC011448, AC092067, KC877710
  5. NM_001384513.1NP_001371442.1  transcriptional repressor p66-alpha isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1 and 4-20 all encode the same isoform (1).
    Source sequence(s)
    AC003030, AC011448
  6. NM_001384514.1NP_001371443.1  transcriptional repressor p66-alpha isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1 and 4-20 all encode the same isoform (1).
    Source sequence(s)
    AC003030, AC011448, AC092067, KC877710
  7. NM_001384515.1NP_001371444.1  transcriptional repressor p66-alpha isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1 and 4-20 all encode the same isoform (1).
    Source sequence(s)
    AC003030, AC011448
  8. NM_001384516.1NP_001371445.1  transcriptional repressor p66-alpha isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Variants 1 and 4-20 all encode the same isoform (1).
    Source sequence(s)
    AC003030, AC011448, KC877710
  9. NM_001384517.1NP_001371446.1  transcriptional repressor p66-alpha isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 1. Variants 1 and 4-20 all encode the same isoform (1).
    Source sequence(s)
    AC003030, AC011448, AC092067
  10. NM_001384518.1NP_001371447.1  transcriptional repressor p66-alpha isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR compared to variant 1. Variants 1 and 4-20 all encode the same isoform (1).
    Source sequence(s)
    AC003030, AC011448
  11. NM_001384519.1NP_001371448.1  transcriptional repressor p66-alpha isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) differs in the 5' UTR compared to variant 1. Variants 1 and 4-20 all encode the same isoform (1).
    Source sequence(s)
    AC003030, AC011448
  12. NM_001384521.1NP_001371450.1  transcriptional repressor p66-alpha isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13) differs in the 5' UTR compared to variant 1. Variants 1 and 4-20 all encode the same isoform (1).
    Source sequence(s)
    AC003030, AC011448, KC877710
  13. NM_001384522.1NP_001371451.1  transcriptional repressor p66-alpha isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14) differs in the 5' UTR compared to variant 1. Variants 1 and 4-20 all encode the same isoform (1).
    Source sequence(s)
    AC003030, AC011448, KC877710
  14. NM_001384523.1NP_001371452.1  transcriptional repressor p66-alpha isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15) differs in the 5' UTR compared to variant 1. Variants 1 and 4-20 all encode the same isoform (1).
    Source sequence(s)
    AC003030, AC011448, AC092067, KC877710
  15. NM_001384524.1NP_001371453.1  transcriptional repressor p66-alpha isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16) differs in the 5' UTR compared to variant 1. Variants 1 and 4-20 all encode the same isoform (1).
    Source sequence(s)
    AC011448, AC092067, KC877710
  16. NM_001384525.1NP_001371454.1  transcriptional repressor p66-alpha isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (17) differs in the 5' UTR compared to variant 1. Variants 1 and 4-20 all encode the same isoform (1).
    Source sequence(s)
    AC011448, AC092067, KC877710
  17. NM_001384526.1NP_001371455.1  transcriptional repressor p66-alpha isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (18) differs in the 5' UTR compared to variant 1. Variants 1 and 4-20 all encode the same isoform (1).
    Source sequence(s)
    AC011448, AC092067, KC877710
  18. NM_001384527.1NP_001371456.1  transcriptional repressor p66-alpha isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (19) differs in the 5' UTR compared to variant 1. Variants 1 and 4-20 all encode the same isoform (1).
    Source sequence(s)
    AC011448, AC092067
  19. NM_001384528.1NP_001371457.1  transcriptional repressor p66-alpha isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (20) differs in the 5' UTR compared to variant 1. Variants 1 and 4-20 all encode the same isoform (1).
    Source sequence(s)
    AC011448, AC092067
  20. NM_001384529.1NP_001371458.1  transcriptional repressor p66-alpha isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (21) differs in the 5' UTR compared to variant 2. Variants 2 and 21-25 all encode the same isoform (2).
    Source sequence(s)
    AC003030, AC011448
  21. NM_001384530.1NP_001371459.1  transcriptional repressor p66-alpha isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (22) differs in the 5' UTR compared to variant 2. Variants 2 and 21-25 all encode the same isoform (2).
    Source sequence(s)
    AC003030, AC011448
  22. NM_001384531.1NP_001371460.1  transcriptional repressor p66-alpha isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (23) differs in the 5' UTR compared to variant 2. Variants 2 and 21-25 all encode the same isoform (2).
    Source sequence(s)
    AC003030, AC011448, KC877710
  23. NM_001384532.1NP_001371461.1  transcriptional repressor p66-alpha isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (24) differs in the 5' UTR compared to variant 2. Variants 2 and 21-25 all encode the same isoform (2).
    Source sequence(s)
    AC011448, AC092067
  24. NM_001384533.1NP_001371462.1  transcriptional repressor p66-alpha isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (25) differs in the 5' UTR compared to variant 2. Variants 2 and 21-25 all encode the same isoform (2).
    Source sequence(s)
    AC011448, AC092067, KC877710
  25. NM_001384534.1NP_001371463.1  transcriptional repressor p66-alpha isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (26) differs in the 5' UTR compared to variant 3. Variants 3 and 26-28 all encode the same isoform (3).
    Source sequence(s)
    AC003030, AC011448, AC092067
  26. NM_001384535.1NP_001371464.1  transcriptional repressor p66-alpha isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (27) differs in the 5' UTR compared to variant 3. Variants 3 and 26-28 all encode the same isoform (3).
    Source sequence(s)
    AC003030, AC011448
  27. NM_001384536.1NP_001371465.1  transcriptional repressor p66-alpha isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (28) differs in the 5' UTR compared to variant 3. Variants 3 and 26-28 all encode the same isoform (3).
    Source sequence(s)
    AC011448, AC092067
  28. NM_001384537.1NP_001371466.1  transcriptional repressor p66-alpha isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (29) encodes the longest isoform (4).
    Source sequence(s)
    AC003030, AC011448
  29. NM_001384538.1NP_001371467.1  transcriptional repressor p66-alpha isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC003030, AC011448
  30. NM_001384539.1NP_001371468.1  transcriptional repressor p66-alpha isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC003030, AC011448
  31. NM_001384540.1NP_001371469.1  transcriptional repressor p66-alpha isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (32), as well as variant 33, encodes isoform 7.
    Source sequence(s)
    AC003030, AC011448
  32. NM_001384541.1NP_001371470.1  transcriptional repressor p66-alpha isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (33), as well as variant 32, encodes isoform 7.
    Source sequence(s)
    AC003030, AC011448
  33. NM_017660.5NP_060130.3  transcriptional repressor p66-alpha isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter by an amino acid, compared to isoform 1. Variants 2 and 21-25 all encode the same isoform (2).
    Source sequence(s)
    AC003030, AC011448
    Consensus CDS
    CCDS12402.2
    UniProtKB/Swiss-Prot
    Q86YP4
    UniProtKB/TrEMBL
    A0A024R7K7
    Related
    ENSP00000353463.3, ENST00000360315.7
    Conserved Domains (2) summary
    pfam00320
    Location:417451
    GATA; GATA zinc finger
    pfam16563
    Location:137173
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

RNA

  1. NR_169268.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC003030, AC011448

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    19385803..19508932
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026903.1XP_016882392.1  transcriptional repressor p66-alpha isoform X3

  2. XM_017026907.1XP_016882396.1  transcriptional repressor p66-alpha isoform X2

  3. XM_011528105.2XP_011526407.1  transcriptional repressor p66-alpha isoform X4

    UniProtKB/Swiss-Prot
    Q86YP4
    UniProtKB/TrEMBL
    A0A024R7M6
    Conserved Domains (2) summary
    pfam00320
    Location:418452
    GATA; GATA zinc finger
    pfam16563
    Location:137173
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
  4. XM_017026905.2XP_016882394.1  transcriptional repressor p66-alpha isoform X3

  5. XM_024451560.1XP_024307328.1  transcriptional repressor p66-alpha isoform X6

    Conserved Domains (2) summary
    pfam00320
    Location:326360
    GATA; GATA zinc finger
    pfam16563
    Location:130
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
  6. XM_024451558.1XP_024307326.1  transcriptional repressor p66-alpha isoform X5

    Conserved Domains (3) summary
    pfam00320
    Location:378412
    GATA; GATA zinc finger
    pfam11221
    Location:776
    Med21; Subunit 21 of Mediator complex
    pfam16563
    Location:4682
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
  7. XM_024451559.1XP_024307327.1  transcriptional repressor p66-alpha isoform X5

    Conserved Domains (3) summary
    pfam00320
    Location:378412
    GATA; GATA zinc finger
    pfam11221
    Location:776
    Med21; Subunit 21 of Mediator complex
    pfam16563
    Location:4682
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
  8. XM_017026910.1XP_016882399.1  transcriptional repressor p66-alpha isoform X3

  9. XM_017026904.1XP_016882393.1  transcriptional repressor p66-alpha isoform X3

  10. XM_017026902.1XP_016882391.1  transcriptional repressor p66-alpha isoform X2

  11. XM_017026901.1XP_016882390.1  transcriptional repressor p66-alpha isoform X1

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