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GATAD2A GATA zinc finger domain containing 2A [ Homo sapiens (human) ]

Gene ID: 54815, updated on 9-Sep-2025
Official Symbol
GATAD2Aprovided by HGNC
Official Full Name
GATA zinc finger domain containing 2Aprovided by HGNC
Primary source
HGNC:HGNC:29989
See related
Ensembl:ENSG00000167491 MIM:614997; AllianceGenome:HGNC:29989
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p66alpha
Summary
Enables protein-macromolecule adaptor activity. Involved in chromatin remodeling and negative regulation of DNA-templated transcription. Located in nucleoplasm. Part of NuRD complex. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in testis (RPKM 18.1), spleen (RPKM 10.8) and 25 other tissues See more
Orthologs
mouse all
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Try the new Transcript table
See GATAD2A in Genome Data Viewer
Location:
19p13.11
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (19385843..19508932)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (19523327..19646416)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (19496652..19619741)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene SURP and G-patch domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14344 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:19431454-19432425 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:19446492-19447691 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:19447717-19448218 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:19452846-19453354 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10437 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10438 Neighboring gene MAU2 sister chromatid cohesion factor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:19459741-19460241 Neighboring gene uncharacterized LOC124904656 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14346 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14347 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14349 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14348 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr19:19481673-19482872 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:19489171-19489816 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10439 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10440 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14350 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:19505798-19506651 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr19:19515640-19516548 and GRCh37_chr19:19516549-19517455 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14352 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10443 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14353 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:19538881-19539384 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:19546839-19547444 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14354 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:19563343-19563843 Neighboring gene microRNA 640 Neighboring gene Sharpr-MPRA regulatory region 5941 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14356 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14357 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:19573083-19573864 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:19583474-19584166 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:19584167-19584858 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10444 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:19585552-19586243 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:19593349-19593956 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:19595063-19595847 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:19599635-19600834 Neighboring gene Sharpr-MPRA regulatory region 10818/8147 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:19602420-19603619 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:19615802-19616302 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10445 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14360 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:19635662-19636637 Neighboring gene Sharpr-MPRA regulatory region 9511 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:19638979-19639479 Neighboring gene NADH:ubiquinone oxidoreductase subunit A13 Neighboring gene testis specific serine kinase 6

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Circular RNA GATAD2A promotes H1N1 replication through inhibiting autophagy. Yu T, et al. Vet Microbiol, 2019 Apr. PMID 30955816
  2. A shared genetic contribution to breast cancer and schizophrenia. Lu D, et al. Nat Commun, 2020 Sep 15. PMID 32934226, Free PMC Article
  3. De novo variants in GATAD2A in individuals with a neurodevelopmental disorder: GATAD2A-related neurodevelopmental disorder. Werren EA, et al. HGG Adv, 2023 Jul 13. PMID 37181331, Free PMC Article
  4. Knockdown of GATAD2A suppresses cell proliferation in thyroid cancer in vitro. Wang Z, et al. Oncol Rep, 2017 Apr. PMID 28260108
  5. p66α Suppresses Breast Cancer Cell Growth and Migration by Acting as Co-Activator of p53. Zhang Q, et al. Cells, 2021 Dec 20. PMID 34944103, Free PMC Article

See all (146) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. De novo variants in GATAD2A in individuals with a neurodevelopmental disorder: GATAD2A-related neurodevelopmental disorder.
    Title: De novo variants in GATAD2A in individuals with a neurodevelopmental disorder: GATAD2A-related neurodevelopmental disorder.
  2. lncKRT16P6 promotes tongue squamous cell carcinoma progression by sponging miR3180 and regulating GATAD2A expression.
    Title: lncKRT16P6 promotes tongue squamous cell carcinoma progression by sponging miR‑3180 and regulating GATAD2A expression.
  3. p66alpha Suppresses Breast Cancer Cell Growth and Migration by Acting as Co-Activator of p53.
    Title: p66α Suppresses Breast Cancer Cell Growth and Migration by Acting as Co-Activator of p53.
  4. Germinal GLT8D1, GATAD2A and SLC25A39 mutations in a patient with a glomangiopericytal tumor and five different sarcomas over a 10-year period.
    Title: Germinal GLT8D1, GATAD2A and SLC25A39 mutations in a patient with a glomangiopericytal tumor and five different sarcomas over a 10-year period.
  5. GATA zinc finger domain-containing protein 2A (GATAD2A) deficiency reactivates fetal haemoglobin in patients with beta-thalassaemia through impaired formation of methyl-binding domain protein 2 (MBD2)-containing nucleosome remodelling and deacetylation (NuRD) complex.
    Title: GATA zinc finger domain-containing protein 2A (GATAD2A) deficiency reactivates fetal haemoglobin in patients with β-thalassaemia through impaired formation of methyl-binding domain protein 2 (MBD2)-containing nucleosome remodelling and deacetylation (NuRD) complex.
  6. A shared genetic contribution to breast cancer and schizophrenia.
    Title: A shared genetic contribution to breast cancer and schizophrenia.
  7. This study unveils a novel biomarker panel consisting of the hsa_circ_0058124/NOTCH3/GATAD2A axis which is critical for papillary thyroid cancer (PTC) tumorigenesis and invasiveness and may represent a novel therapeutic target for intervening in PTC progression.
    Title: Hsa_circ_0058124 promotes papillary thyroid cancer tumorigenesis and invasiveness through the NOTCH3/GATAD2A axis.
  8. circ-GATAD2A promotes the replication of H1N1 by inhibiting autophagy.
    Title: Circular RNA GATAD2A promotes H1N1 replication through inhibiting autophagy.
  9. The MYND domain of ZMYND8 directly interacts with PPPLPhi motifs in the NuRD subunit GATAD2A.
    Title: ZMYND8 Co-localizes with NuRD on Target Genes and Regulates Poly(ADP-Ribose)-Dependent Recruitment of GATAD2A/NuRD to Sites of DNA Damage.
  10. Results showed that suppression of GATAD2A attenuated thyroid cancer cell proliferation and colony formation and promoted apoptosis suggesting it as an essential factor in thyroid cancer cell pathogenesis.
    Title: Knockdown of GATAD2A suppresses cell proliferation in thyroid cancer in vitro.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
EBI GWAS Catalog
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
EBI GWAS Catalog

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Replication interactions

Interaction Pubs
Knockdown of GATA zinc finger domain containing 2A (GATAD2A) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat Methyl-CpG-binding proteins MBD2 and p66alpha are identified to interact with HIV-1 Tat in Jurkat cell PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ20085, FLJ21017

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-macromolecule adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell fate specification NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of stem cell differentiation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of NuRD complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NuRD complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of NuRD complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
transcriptional repressor p66-alpha
Names
GATA zinc finger domain-containing protein 2A

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300946.3 → NP_001287875.1  transcriptional repressor p66-alpha isoform 1

    See identical proteins and their annotated locations for NP_001287875.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1. Variants 1 and 4-20 all encode the same isoform (1).
    Source sequence(s)
    AC003030, AC011448, KC877710
    Consensus CDS
    CCDS77270.1
    Conserved Domains (3) summary
    pfam00320
    Location:418 → 452
    GATA; GATA zinc finger
    pfam16563
    Location:137 → 173
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
    NF033849
    Location:514 → 621
    ser_rich_anae_1; serine-rich protein

  2. NM_001359631.2 → NP_001346560.1  transcriptional repressor p66-alpha isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes isoform 3. Variants 3 and 26-28 all encode the same isoform (3).
    Source sequence(s)
    AC003030, AC011448
    Conserved Domains (2) summary
    pfam00320
    Location:418 → 452
    GATA; GATA zinc finger
    pfam16563
    Location:137 → 173
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

  3. NM_001384511.1 → NP_001371440.1  transcriptional repressor p66-alpha isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 and 4-20 all encode the same isoform (1).
    Source sequence(s)
    AC003030, AC011448, KC877710
    Consensus CDS
    CCDS77270.1
    Related
    ENSP00000538364.1, ENST00000868305.1
    Conserved Domains (3) summary
    pfam00320
    Location:418 → 452
    GATA; GATA zinc finger
    pfam16563
    Location:137 → 173
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
    NF033849
    Location:514 → 621
    ser_rich_anae_1; serine-rich protein

  4. NM_001384512.1 → NP_001371441.1  transcriptional repressor p66-alpha isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1 and 4-20 all encode the same isoform (1).
    Source sequence(s)
    AC003030, AC011448, AC092067, KC877710
    Consensus CDS
    CCDS77270.1
    Related
    ENSP00000538372.1, ENST00000868313.1
    Conserved Domains (3) summary
    pfam00320
    Location:418 → 452
    GATA; GATA zinc finger
    pfam16563
    Location:137 → 173
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
    NF033849
    Location:514 → 621
    ser_rich_anae_1; serine-rich protein

  5. NM_001384513.1 → NP_001371442.1  transcriptional repressor p66-alpha isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1 and 4-20 all encode the same isoform (1).
    Source sequence(s)
    AC003030, AC011448
    Consensus CDS
    CCDS77270.1
    Related
    ENSP00000538370.1, ENST00000868311.1
    Conserved Domains (3) summary
    pfam00320
    Location:418 → 452
    GATA; GATA zinc finger
    pfam16563
    Location:137 → 173
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
    NF033849
    Location:514 → 621
    ser_rich_anae_1; serine-rich protein

  6. NM_001384514.1 → NP_001371443.1  transcriptional repressor p66-alpha isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1 and 4-20 all encode the same isoform (1).
    Source sequence(s)
    AC003030, AC011448, AC092067, KC877710
    Consensus CDS
    CCDS77270.1
    Conserved Domains (3) summary
    pfam00320
    Location:418 → 452
    GATA; GATA zinc finger
    pfam16563
    Location:137 → 173
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
    NF033849
    Location:514 → 621
    ser_rich_anae_1; serine-rich protein

  7. NM_001384515.1 → NP_001371444.1  transcriptional repressor p66-alpha isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1 and 4-20 all encode the same isoform (1).
    Source sequence(s)
    AC003030, AC011448
    Consensus CDS
    CCDS77270.1
    Conserved Domains (3) summary
    pfam00320
    Location:418 → 452
    GATA; GATA zinc finger
    pfam16563
    Location:137 → 173
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
    NF033849
    Location:514 → 621
    ser_rich_anae_1; serine-rich protein

  8. NM_001384516.1 → NP_001371445.1  transcriptional repressor p66-alpha isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Variants 1 and 4-20 all encode the same isoform (1).
    Source sequence(s)
    AC003030, AC011448, KC877710
    Consensus CDS
    CCDS77270.1
    Related
    ENSP00000585115.1, ENST00000915056.1
    Conserved Domains (3) summary
    pfam00320
    Location:418 → 452
    GATA; GATA zinc finger
    pfam16563
    Location:137 → 173
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
    NF033849
    Location:514 → 621
    ser_rich_anae_1; serine-rich protein

  9. NM_001384517.1 → NP_001371446.1  transcriptional repressor p66-alpha isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 1. Variants 1 and 4-20 all encode the same isoform (1).
    Source sequence(s)
    AC003030, AC011448, AC092067
    Consensus CDS
    CCDS77270.1
    Related
    ENSP00000538368.1, ENST00000868309.1
    Conserved Domains (3) summary
    pfam00320
    Location:418 → 452
    GATA; GATA zinc finger
    pfam16563
    Location:137 → 173
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
    NF033849
    Location:514 → 621
    ser_rich_anae_1; serine-rich protein

  10. NM_001384518.1 → NP_001371447.1  transcriptional repressor p66-alpha isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR compared to variant 1. Variants 1 and 4-20 all encode the same isoform (1).
    Source sequence(s)
    AC003030, AC011448
    Consensus CDS
    CCDS77270.1
    Related
    ENSP00000538379.1, ENST00000868320.1
    Conserved Domains (3) summary
    pfam00320
    Location:418 → 452
    GATA; GATA zinc finger
    pfam16563
    Location:137 → 173
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
    NF033849
    Location:514 → 621
    ser_rich_anae_1; serine-rich protein

  11. NM_001384519.1 → NP_001371448.1  transcriptional repressor p66-alpha isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) differs in the 5' UTR compared to variant 1. Variants 1 and 4-20 all encode the same isoform (1).
    Source sequence(s)
    AC003030, AC011448
    Consensus CDS
    CCDS77270.1
    Related
    ENSP00000538363.1, ENST00000868304.1
    Conserved Domains (3) summary
    pfam00320
    Location:418 → 452
    GATA; GATA zinc finger
    pfam16563
    Location:137 → 173
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
    NF033849
    Location:514 → 621
    ser_rich_anae_1; serine-rich protein

  12. NM_001384521.1 → NP_001371450.1  transcriptional repressor p66-alpha isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13) differs in the 5' UTR compared to variant 1. Variants 1 and 4-20 all encode the same isoform (1).
    Source sequence(s)
    AC003030, AC011448, KC877710
    Consensus CDS
    CCDS77270.1
    Conserved Domains (3) summary
    pfam00320
    Location:418 → 452
    GATA; GATA zinc finger
    pfam16563
    Location:137 → 173
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
    NF033849
    Location:514 → 621
    ser_rich_anae_1; serine-rich protein

  13. NM_001384522.1 → NP_001371451.1  transcriptional repressor p66-alpha isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14) differs in the 5' UTR compared to variant 1. Variants 1 and 4-20 all encode the same isoform (1).
    Source sequence(s)
    AC003030, AC011448, KC877710
    Consensus CDS
    CCDS77270.1
    Conserved Domains (3) summary
    pfam00320
    Location:418 → 452
    GATA; GATA zinc finger
    pfam16563
    Location:137 → 173
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
    NF033849
    Location:514 → 621
    ser_rich_anae_1; serine-rich protein

  14. NM_001384523.1 → NP_001371452.1  transcriptional repressor p66-alpha isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15) differs in the 5' UTR compared to variant 1. Variants 1 and 4-20 all encode the same isoform (1).
    Source sequence(s)
    AC003030, AC011448, AC092067, KC877710
    Consensus CDS
    CCDS77270.1
    Related
    ENSP00000538369.1, ENST00000868310.1
    Conserved Domains (3) summary
    pfam00320
    Location:418 → 452
    GATA; GATA zinc finger
    pfam16563
    Location:137 → 173
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
    NF033849
    Location:514 → 621
    ser_rich_anae_1; serine-rich protein

  15. NM_001384524.1 → NP_001371453.1  transcriptional repressor p66-alpha isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16) differs in the 5' UTR compared to variant 1. Variants 1 and 4-20 all encode the same isoform (1).
    Source sequence(s)
    AC011448, AC092067, KC877710
    Consensus CDS
    CCDS77270.1
    Conserved Domains (3) summary
    pfam00320
    Location:418 → 452
    GATA; GATA zinc finger
    pfam16563
    Location:137 → 173
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
    NF033849
    Location:514 → 621
    ser_rich_anae_1; serine-rich protein

  16. NM_001384525.1 → NP_001371454.1  transcriptional repressor p66-alpha isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (17) differs in the 5' UTR compared to variant 1. Variants 1 and 4-20 all encode the same isoform (1).
    Source sequence(s)
    AC011448, AC092067, KC877710
    Consensus CDS
    CCDS77270.1
    Conserved Domains (3) summary
    pfam00320
    Location:418 → 452
    GATA; GATA zinc finger
    pfam16563
    Location:137 → 173
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
    NF033849
    Location:514 → 621
    ser_rich_anae_1; serine-rich protein

  17. NM_001384526.1 → NP_001371455.1  transcriptional repressor p66-alpha isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (18) differs in the 5' UTR compared to variant 1. Variants 1 and 4-20 all encode the same isoform (1).
    Source sequence(s)
    AC011448, AC092067, KC877710
    Consensus CDS
    CCDS77270.1
    Related
    ENSP00000585117.1, ENST00000915058.1
    Conserved Domains (3) summary
    pfam00320
    Location:418 → 452
    GATA; GATA zinc finger
    pfam16563
    Location:137 → 173
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
    NF033849
    Location:514 → 621
    ser_rich_anae_1; serine-rich protein

  18. NM_001384527.1 → NP_001371456.1  transcriptional repressor p66-alpha isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (19) differs in the 5' UTR compared to variant 1. Variants 1 and 4-20 all encode the same isoform (1).
    Source sequence(s)
    AC011448, AC092067
    Consensus CDS
    CCDS77270.1
    Related
    ENSP00000538374.1, ENST00000868315.1
    Conserved Domains (3) summary
    pfam00320
    Location:418 → 452
    GATA; GATA zinc finger
    pfam16563
    Location:137 → 173
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
    NF033849
    Location:514 → 621
    ser_rich_anae_1; serine-rich protein

  19. NM_001384528.1 → NP_001371457.1  transcriptional repressor p66-alpha isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (20) differs in the 5' UTR compared to variant 1. Variants 1 and 4-20 all encode the same isoform (1).
    Source sequence(s)
    AC011448, AC092067
    Consensus CDS
    CCDS77270.1
    Related
    ENSP00000508398.1, ENST00000683918.1
    Conserved Domains (3) summary
    pfam00320
    Location:418 → 452
    GATA; GATA zinc finger
    pfam16563
    Location:137 → 173
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
    NF033849
    Location:514 → 621
    ser_rich_anae_1; serine-rich protein

  20. NM_001384529.1 → NP_001371458.1  transcriptional repressor p66-alpha isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (21) differs in the 5' UTR compared to variant 2. Variants 2 and 21-25 all encode the same isoform (2).
    Source sequence(s)
    AC003030, AC011448
    Consensus CDS
    CCDS12402.2
    UniProtKB/Swiss-Prot
    B5MC40, Q7L3J2, Q86YP4, Q96F28, Q9NPU2, Q9NXS1
    Conserved Domains (3) summary
    pfam00320
    Location:417 → 451
    GATA; GATA zinc finger
    pfam16563
    Location:137 → 173
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
    NF033849
    Location:513 → 620
    ser_rich_anae_1; serine-rich protein

  21. NM_001384530.1 → NP_001371459.1  transcriptional repressor p66-alpha isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (22) differs in the 5' UTR compared to variant 2. Variants 2 and 21-25 all encode the same isoform (2).
    Source sequence(s)
    AC003030, AC011448
    Consensus CDS
    CCDS12402.2
    UniProtKB/Swiss-Prot
    B5MC40, Q7L3J2, Q86YP4, Q96F28, Q9NPU2, Q9NXS1
    Related
    ENSP00000538365.1, ENST00000868306.1
    Conserved Domains (3) summary
    pfam00320
    Location:417 → 451
    GATA; GATA zinc finger
    pfam16563
    Location:137 → 173
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
    NF033849
    Location:513 → 620
    ser_rich_anae_1; serine-rich protein

  22. NM_001384531.1 → NP_001371460.1  transcriptional repressor p66-alpha isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (23) differs in the 5' UTR compared to variant 2. Variants 2 and 21-25 all encode the same isoform (2).
    Source sequence(s)
    AC003030, AC011448, KC877710
    Consensus CDS
    CCDS12402.2
    UniProtKB/Swiss-Prot
    B5MC40, Q7L3J2, Q86YP4, Q96F28, Q9NPU2, Q9NXS1
    Conserved Domains (3) summary
    pfam00320
    Location:417 → 451
    GATA; GATA zinc finger
    pfam16563
    Location:137 → 173
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
    NF033849
    Location:513 → 620
    ser_rich_anae_1; serine-rich protein

  23. NM_001384532.1 → NP_001371461.1  transcriptional repressor p66-alpha isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (24) differs in the 5' UTR compared to variant 2. Variants 2 and 21-25 all encode the same isoform (2).
    Source sequence(s)
    AC011448, AC092067
    Consensus CDS
    CCDS12402.2
    UniProtKB/Swiss-Prot
    B5MC40, Q7L3J2, Q86YP4, Q96F28, Q9NPU2, Q9NXS1
    Related
    ENSP00000538377.1, ENST00000868318.1
    Conserved Domains (3) summary
    pfam00320
    Location:417 → 451
    GATA; GATA zinc finger
    pfam16563
    Location:137 → 173
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
    NF033849
    Location:513 → 620
    ser_rich_anae_1; serine-rich protein

  24. NM_001384533.1 → NP_001371462.1  transcriptional repressor p66-alpha isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (25) differs in the 5' UTR compared to variant 2. Variants 2 and 21-25 all encode the same isoform (2).
    Source sequence(s)
    AC011448, AC092067, KC877710
    Consensus CDS
    CCDS12402.2
    UniProtKB/Swiss-Prot
    B5MC40, Q7L3J2, Q86YP4, Q96F28, Q9NPU2, Q9NXS1
    Related
    ENSP00000585121.1, ENST00000915062.1
    Conserved Domains (3) summary
    pfam00320
    Location:417 → 451
    GATA; GATA zinc finger
    pfam16563
    Location:137 → 173
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
    NF033849
    Location:513 → 620
    ser_rich_anae_1; serine-rich protein

  25. NM_001384534.1 → NP_001371463.1  transcriptional repressor p66-alpha isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (26) differs in the 5' UTR compared to variant 3. Variants 3 and 26-28 all encode the same isoform (3).
    Source sequence(s)
    AC003030, AC011448, AC092067
    Conserved Domains (2) summary
    pfam00320
    Location:418 → 452
    GATA; GATA zinc finger
    pfam16563
    Location:137 → 173
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

  26. NM_001384535.1 → NP_001371464.1  transcriptional repressor p66-alpha isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (27) differs in the 5' UTR compared to variant 3. Variants 3 and 26-28 all encode the same isoform (3).
    Source sequence(s)
    AC003030, AC011448
    Related
    ENSP00000538367.1, ENST00000868308.1
    Conserved Domains (2) summary
    pfam00320
    Location:418 → 452
    GATA; GATA zinc finger
    pfam16563
    Location:137 → 173
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

  27. NM_001384536.1 → NP_001371465.1  transcriptional repressor p66-alpha isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (28) differs in the 5' UTR compared to variant 3. Variants 3 and 26-28 all encode the same isoform (3).
    Source sequence(s)
    AC011448, AC092067
    Related
    ENSP00000585119.1, ENST00000915060.1
    Conserved Domains (2) summary
    pfam00320
    Location:418 → 452
    GATA; GATA zinc finger
    pfam16563
    Location:137 → 173
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

  28. NM_001384537.1 → NP_001371466.1  transcriptional repressor p66-alpha isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (29) encodes the longest isoform (4).
    Source sequence(s)
    AC003030, AC011448
    Related
    ENSP00000538375.1, ENST00000868316.1
    Conserved Domains (3) summary
    pfam00320
    Location:469 → 503
    GATA; GATA zinc finger
    pfam16563
    Location:137 → 173
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
    NF033849
    Location:565 → 672
    ser_rich_anae_1; serine-rich protein

  29. NM_001384538.1 → NP_001371467.1  transcriptional repressor p66-alpha isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC003030, AC011448
    Related
    ENSP00000626425.1, ENST00000956366.1
    Conserved Domains (2) summary
    pfam00320
    Location:417 → 451
    GATA; GATA zinc finger
    pfam16563
    Location:137 → 173
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

  30. NM_001384539.1 → NP_001371468.1  transcriptional repressor p66-alpha isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC003030, AC011448
    Related
    ENSP00000538371.1, ENST00000868312.1
    Conserved Domains (3) summary
    pfam00320
    Location:388 → 422
    GATA; GATA zinc finger
    pfam16563
    Location:137 → 173
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
    NF033849
    Location:484 → 591
    ser_rich_anae_1; serine-rich protein

  31. NM_001384540.1 → NP_001371469.1  transcriptional repressor p66-alpha isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (32), as well as variant 33, encodes isoform 7.
    Source sequence(s)
    AC003030, AC011448
    UniProtKB/TrEMBL
    B4DKZ7
    Conserved Domains (3) summary
    pfam00320
    Location:275 → 309
    GATA; GATA zinc finger
    pfam16563
    Location:1 → 30
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
    NF033849
    Location:371 → 478
    ser_rich_anae_1; serine-rich protein

  32. NM_001384541.1 → NP_001371470.1  transcriptional repressor p66-alpha isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (33), as well as variant 32, encodes isoform 7.
    Source sequence(s)
    AC003030, AC011448
    UniProtKB/TrEMBL
    B4DKZ7
    Conserved Domains (3) summary
    pfam00320
    Location:275 → 309
    GATA; GATA zinc finger
    pfam16563
    Location:1 → 30
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
    NF033849
    Location:371 → 478
    ser_rich_anae_1; serine-rich protein

  33. NM_017660.5 → NP_060130.3  transcriptional repressor p66-alpha isoform 2

    See identical proteins and their annotated locations for NP_060130.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter by an amino acid, compared to isoform 1. Variants 2 and 21-25 all encode the same isoform (2).
    Source sequence(s)
    AC003030, AC011448
    Consensus CDS
    CCDS12402.2
    UniProtKB/Swiss-Prot
    B5MC40, Q7L3J2, Q86YP4, Q96F28, Q9NPU2, Q9NXS1
    Related
    ENSP00000353463.3, ENST00000360315.7
    Conserved Domains (3) summary
    pfam00320
    Location:417 → 451
    GATA; GATA zinc finger
    pfam16563
    Location:137 → 173
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
    NF033849
    Location:513 → 620
    ser_rich_anae_1; serine-rich protein

RNA

  1. NR_169268.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC003030, AC011448

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    19385843..19508932
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439009.1 → XP_047294965.1  transcriptional repressor p66-alpha isoform X6

  2. XM_047439000.1 → XP_047294956.1  transcriptional repressor p66-alpha isoform X3

  3. XM_047439002.1 → XP_047294958.1  transcriptional repressor p66-alpha isoform X5

  4. XM_047439006.1 → XP_047294962.1  transcriptional repressor p66-alpha isoform X5

  5. XM_047438999.1 → XP_047294955.1  transcriptional repressor p66-alpha isoform X2

  6. XM_047439003.1 → XP_047294959.1  transcriptional repressor p66-alpha isoform X5

  7. XM_047439005.1 → XP_047294961.1  transcriptional repressor p66-alpha isoform X5

  8. XM_047439007.1 → XP_047294963.1  transcriptional repressor p66-alpha isoform X5

  9. XM_047439001.1 → XP_047294957.1  transcriptional repressor p66-alpha isoform X4

  10. XM_047438998.1 → XP_047294954.1  transcriptional repressor p66-alpha isoform X1

  11. XM_047439004.1 → XP_047294960.1  transcriptional repressor p66-alpha isoform X5

    Related
    ENSP00000538381.1, ENST00000868322.1

  12. XM_047439010.1 → XP_047294966.1  transcriptional repressor p66-alpha isoform X7

    UniProtKB/TrEMBL
    B4DKZ7

  13. XM_047439011.1 → XP_047294967.1  transcriptional repressor p66-alpha isoform X7

    UniProtKB/TrEMBL
    B4DKZ7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    19523327..19646416
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321323.1 → XP_054177298.1  transcriptional repressor p66-alpha isoform X6

  2. XM_054321314.1 → XP_054177289.1  transcriptional repressor p66-alpha isoform X3

  3. XM_054321318.1 → XP_054177293.1  transcriptional repressor p66-alpha isoform X5

  4. XM_054321321.1 → XP_054177296.1  transcriptional repressor p66-alpha isoform X5

  5. XM_054321320.1 → XP_054177295.1  transcriptional repressor p66-alpha isoform X5

  6. XM_054321322.1 → XP_054177297.1  transcriptional repressor p66-alpha isoform X5

  7. XM_054321313.1 → XP_054177288.1  transcriptional repressor p66-alpha isoform X2

  8. XM_054321317.1 → XP_054177292.1  transcriptional repressor p66-alpha isoform X4

  9. XM_054321312.1 → XP_054177287.1  transcriptional repressor p66-alpha isoform X1

  10. XM_054321326.1 → XP_054177301.1  transcriptional repressor p66-alpha isoform X11

  11. XM_054321315.1 → XP_054177290.1  transcriptional repressor p66-alpha isoform X9

  12. XM_054321311.1 → XP_054177286.1  transcriptional repressor p66-alpha isoform X8

    UniProtKB/Swiss-Prot
    B5MC40, Q7L3J2, Q86YP4, Q96F28, Q9NPU2, Q9NXS1

  13. XM_054321316.1 → XP_054177291.1  transcriptional repressor p66-alpha isoform X10

  14. XM_054321319.1 → XP_054177294.1  transcriptional repressor p66-alpha isoform X5

  15. XM_054321324.1 → XP_054177299.1  transcriptional repressor p66-alpha isoform X7

    UniProtKB/TrEMBL
    B4DKZ7

  16. XM_054321325.1 → XP_054177300.1  transcriptional repressor p66-alpha isoform X7

    UniProtKB/TrEMBL
    B4DKZ7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86YP4.1 GenPept UniProtKB/Swiss-Prot:Q86YP4

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