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RHOQ ras homolog family member Q [ Homo sapiens (human) ]

Gene ID: 23433, updated on 7-Jun-2020

Summary

Official Symbol
RHOQprovided by HGNC
Official Full Name
ras homolog family member Qprovided by HGNC
Primary source
HGNC:HGNC:17736
See related
Ensembl:ENSG00000119729 MIM:605857
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARHQ; TC10; TC10A; RASL7A; HEL-S-42
Summary
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein is an important signalling protein for sarcomere assembly and has been shown to play a significant role in the exocytosis of the solute carrier family 2, facilitated glucose transporter member 4 and other proteins, possibly acting as the signal that turns on the membrane fusion machinery. Three related pseudogene have been identified on chromosomes 2 and 14. [provided by RefSeq, Aug 2011]
Expression
Ubiquitous expression in fat (RPKM 72.1), heart (RPKM 55.0) and 24 other tissues See more
Orthologs

Genomic context

See RHOQ in Genome Data Viewer
Location:
2p21
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (46542409..46584688)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (46769867..46811827)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 817, pseudogene Neighboring gene transmembrane protein 247 Neighboring gene ATPase H+ transporting V1 subunit E2 Neighboring gene RHOQ antisense RNA 1 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class F Neighboring gene CXXC repeat containing interactor of PDZ3 domain Neighboring gene uncharacterized LOC105374584

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GBD domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
profilin binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
GTP metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell projection assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to insulin stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cortical actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cortical actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of filopodium assembly IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of glucose import IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
regulation of actin cytoskeleton organization IC
Inferred by Curator
more info
PubMed 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi-associated vesicle membrane TAS
Traceable Author Statement
more info
 
actin filament IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
membrane raft IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
rho-related GTP-binding protein RhoQ
Names
RAS-like, family 7, member A
epididymis secretory protein Li 42
ras homolog gene family, member Q
ras-like protein TC10
ras-like protein family member 7A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012249.4NP_036381.2  rho-related GTP-binding protein RhoQ

    See identical proteins and their annotated locations for NP_036381.2

    Status: VALIDATED

    Source sequence(s)
    AC018682, BC056154
    Consensus CDS
    CCDS33191.1
    UniProtKB/Swiss-Prot
    P17081
    UniProtKB/TrEMBL
    V9HWD0
    Related
    ENSP00000238738.4, ENST00000238738.9
    Conserved Domains (1) summary
    cd04135
    Location:10183
    Tc10; Rho GTPase TC10 (Tc10)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    46542409..46584688
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017003716.1XP_016859205.1  rho-related GTP-binding protein RhoQ isoform X2

    Conserved Domains (2) summary
    TIGR00231
    Location:11157
    small_GTP; small GTP-binding protein domain
    cl21455
    Location:10155
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. XM_011532726.2XP_011531028.1  rho-related GTP-binding protein RhoQ isoform X1

    Conserved Domains (2) summary
    smart00174
    Location:12157
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
    cl21455
    Location:10166
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. XM_005264229.2XP_005264286.1  rho-related GTP-binding protein RhoQ isoform X3

    Conserved Domains (2) summary
    smart00174
    Location:1298
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
    cl21455
    Location:1096
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  4. XM_011532728.2XP_011531030.1  rho-related GTP-binding protein RhoQ isoform X4

    See identical proteins and their annotated locations for XP_011531030.1

    UniProtKB/TrEMBL
    D6W5A7
    Conserved Domains (1) summary
    cl21455
    Location:16135
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
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