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RHOQ ras homolog family member Q [ Homo sapiens (human) ]

Gene ID: 23433, updated on 7-Dec-2018

Summary

Official Symbol
RHOQprovided by HGNC
Official Full Name
ras homolog family member Qprovided by HGNC
Primary source
HGNC:HGNC:17736
See related
Ensembl:ENSG00000119729 MIM:605857
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARHQ; TC10; TC10A; RASL7A; HEL-S-42
Summary
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein is an important signalling protein for sarcomere assembly and has been shown to play a significant role in the exocytosis of the solute carrier family 2, facilitated glucose transporter member 4 and other proteins, possibly acting as the signal that turns on the membrane fusion machinery. Three related pseudogene have been identified on chromosomes 2 and 14. [provided by RefSeq, Aug 2011]
Expression
Ubiquitous expression in fat (RPKM 72.1), heart (RPKM 55.0) and 24 other tissues See more
Orthologs

Genomic context

See RHOQ in Genome Data Viewer
Location:
2p21
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (46542409..46584688)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (46769867..46811827)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 817, pseudogene Neighboring gene transmembrane protein 247 Neighboring gene ATPase H+ transporting V1 subunit E2 Neighboring gene uncharacterized LOC100506142 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class F Neighboring gene CXXC repeat containing interactor of PDZ3 domain Neighboring gene uncharacterized LOC105374584

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Angiopoietin Like Protein 8 Regulatory Pathway, organism-specific biosystem (from WikiPathways)
    Angiopoietin Like Protein 8 Regulatory Pathway, organism-specific biosystemThe hepatic ANGPTL8 (Angiopoietin Like Protein 8) regulatory pathway represents an up-to-date curated interactive pathway for all of the interactions from the known regulators of ANGPTL8 and updated ...
  • Insulin Pathway, organism-specific biosystem (from Pathway Interaction Database)
    Insulin Pathway, organism-specific biosystem
    Insulin Pathway
  • Insulin Signaling, organism-specific biosystem (from WikiPathways)
    Insulin Signaling, organism-specific biosystemInsulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose fro...
  • Insulin signaling pathway, organism-specific biosystem (from KEGG)
    Insulin signaling pathway, organism-specific biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
  • Insulin signaling pathway, conserved biosystem (from KEGG)
    Insulin signaling pathway, conserved biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
  • Insulin-mediated glucose transport, organism-specific biosystem (from Pathway Interaction Database)
    Insulin-mediated glucose transport, organism-specific biosystem
    Insulin-mediated glucose transport
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
    RHO GTPase Effectors, organism-specific biosystemRHO GTPases regulate cell behaviour by activating a number of downstream effectors that regulate cytoskeletal organization, intracellular trafficking and transcription (reviewed by Sahai and Marshall...
  • RHO GTPases regulate CFTR trafficking, organism-specific biosystem (from REACTOME)
    RHO GTPases regulate CFTR trafficking, organism-specific biosystemActivated RHO GTPase RHOQ (TC10) regulates the trafficking of CFTR (cystic fibrosis transmembrane conductance regulator) by binding to GOPC (Golgi-associated and PDZ and coiled-coil motif-containing ...
  • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
    Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
  • Translocation of GLUT4 to the plasma membrane, organism-specific biosystem (from REACTOME)
    Translocation of GLUT4 to the plasma membrane, organism-specific biosystemIn adipocytes and myocytes insulin signaling causes intracellular vesicles carrying the GLUT4 (SLC2A4) glucose transporter to translocate to the plasma membrane, allowing the cells to take up glucose...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GBD domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
profilin binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
GTP metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell projection assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to insulin stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cortical actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
establishment or maintenance of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of filopodium assembly IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of glucose import IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of actin cytoskeleton organization IC
Inferred by Curator
more info
PubMed 
regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Golgi-associated vesicle membrane TAS
Traceable Author Statement
more info
 
actin filament IDA
Inferred from Direct Assay
more info
PubMed 
cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
membrane raft IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
rho-related GTP-binding protein RhoQ
Names
RAS-like, family 7, member A
epididymis secretory protein Li 42
ras homolog gene family, member Q
ras-like protein TC10
ras-like protein family member 7A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012249.4NP_036381.2  rho-related GTP-binding protein RhoQ precursor

    See identical proteins and their annotated locations for NP_036381.2

    Status: VALIDATED

    Source sequence(s)
    AC018682, BC056154
    Consensus CDS
    CCDS33191.1
    UniProtKB/Swiss-Prot
    P17081
    UniProtKB/TrEMBL
    V9HWD0
    Related
    ENSP00000238738.4, ENST00000238738.8
    Conserved Domains (1) summary
    cd04135
    Location:10183
    Tc10; Rho GTPase TC10 (Tc10)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    46542409..46584688
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017003716.1XP_016859205.1  rho-related GTP-binding protein RhoQ isoform X2

    Conserved Domains (2) summary
    TIGR00231
    Location:11157
    small_GTP; small GTP-binding protein domain
    cl21455
    Location:10155
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. XM_011532726.2XP_011531028.1  rho-related GTP-binding protein RhoQ isoform X1

    Conserved Domains (2) summary
    smart00174
    Location:12157
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
    cl21455
    Location:10166
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. XM_005264229.2XP_005264286.1  rho-related GTP-binding protein RhoQ isoform X3

    Conserved Domains (2) summary
    smart00174
    Location:1298
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
    cl21455
    Location:1096
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  4. XM_011532728.2XP_011531030.1  rho-related GTP-binding protein RhoQ isoform X4

    See identical proteins and their annotated locations for XP_011531030.1

    UniProtKB/TrEMBL
    D6W5A7
    Conserved Domains (1) summary
    cl21455
    Location:16135
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
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