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GPR161 G protein-coupled receptor 161 [ Homo sapiens (human) ]

Gene ID: 23432, updated on 5-Aug-2018

Summary

Official Symbol
GPR161provided by HGNC
Official Full Name
G protein-coupled receptor 161provided by HGNC
Primary source
HGNC:HGNC:23694
See related
Ensembl:ENSG00000143147 MIM:612250; Vega:OTTHUMG00000034651
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RE2
Summary
The protein encoded by this gene is an orphan G protein-coupled receptor whose ligand is unknown. This gene is overexpressed in triple-negative breast cancer, and disruption of this gene slows the proliferation of basal breast cancer cells. Therefore, this gene is a potential drug target for triple-negative breast cancer. [provided by RefSeq, Mar 2017]
Expression
Broad expression in endometrium (RPKM 8.0), esophagus (RPKM 3.6) and 20 other tissues See more
Orthologs

Genomic context

See GPR161 in Genome Data Viewer
Location:
1q24.2
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (168079542..168137667, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (168048780..168106905, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene DDB1 and CUL4 associated factor 6 Neighboring gene microRNA 1255b-2 Neighboring gene glycine cleavage system protein H pseudogene 5 Neighboring gene TOR signaling pathway regulator Neighboring gene ribosomal protein L34 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
  • Hedgehog 'off' state, organism-specific biosystem (from REACTOME)
    Hedgehog 'off' state, organism-specific biosystemHedgehog is a secreted morphogen that has evolutionarily conserved roles in body organization by regulating the activity of the Ci/Gli transcription factor family. In Drosophila in the absence of Hh ...
  • Hedgehog 'on' state, organism-specific biosystem (from REACTOME)
    Hedgehog 'on' state, organism-specific biosystemHedgehog is a secreted morphogen that has evolutionarily conserved roles in body organization by regulating the activity of the Ci/Gli transcription factor family. In Drosophila in the absence of Hh ...
  • Hedgehog signaling pathway, organism-specific biosystem (from KEGG)
    Hedgehog signaling pathway, organism-specific biosystemThe Hedgehog (Hh) signaling pathway has numerous roles in the control of cell proliferation, tissue patterning, stem cell maintenance and development. The primary cilium is an important center for tr...
  • Hedgehog signaling pathway, conserved biosystem (from KEGG)
    Hedgehog signaling pathway, conserved biosystemThe Hedgehog (Hh) signaling pathway has numerous roles in the control of cell proliferation, tissue patterning, stem cell maintenance and development. The primary cilium is an important center for tr...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Hedgehog, organism-specific biosystem (from REACTOME)
    Signaling by Hedgehog, organism-specific biosystemHedgehog (Hh) is a secreted morphogen that regulates developmental processes in vertebrates including limb bud formation, neural tube patterning, cell growth and differentiation (reviewed in Hui and ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ33952

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein coupled receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
adenylate cyclase-activating G-protein coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
ciliary membrane TAS
Traceable Author Statement
more info
 
cilium ISS
Inferred from Sequence or Structural Similarity
more info
 
endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
recycling endosome ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
G-protein coupled receptor 161
Names
G-protein coupled receptor RE2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053052.1 RefSeqGene

    Range
    5961..63126
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001267609.1NP_001254538.1  G-protein coupled receptor 161 isoform 1

    See identical proteins and their annotated locations for NP_001254538.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA662800, AK299634, AL033532
    Consensus CDS
    CCDS58043.1
    UniProtKB/Swiss-Prot
    Q8N6U8
    Related
    ENSP00000441039.1, ENST00000537209.5
    Conserved Domains (2) summary
    pfam00001
    Location:64344
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:55184
    7tm_4; Olfactory receptor
  2. NM_001267610.1NP_001254539.1  G-protein coupled receptor 161 isoform 2

    See identical proteins and their annotated locations for NP_001254539.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2, 3, 8, 9, and 10 all encode the same isoform (2).
    Source sequence(s)
    AA662800, AK122656, AL033532
    Consensus CDS
    CCDS1268.1
    UniProtKB/Swiss-Prot
    Q8N6U8
    Related
    ENSP00000356809.1, OTTHUMP00000032587, ENST00000367835.1, OTTHUMT00000083830
    Conserved Domains (1) summary
    cd15214
    Location:29335
    7tmA_GPR161; orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. NM_001267611.1NP_001254540.1  G-protein coupled receptor 161 isoform 3

    See identical proteins and their annotated locations for NP_001254540.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks a portion of the 5' coding region, and initiates translation at an upstream start codon, compared to variant 1. The resulting isoform (3) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AA662800, AK310019, AL033532
    Consensus CDS
    CCDS72978.1
    UniProtKB/TrEMBL
    A0A0A0MQW8
    Related
    ENSP00000271357.6, ENST00000271357.9
    Conserved Domains (2) summary
    pfam00001
    Location:61341
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:52181
    7tm_4; Olfactory receptor
  4. NM_001267612.1NP_001254541.1  G-protein coupled receptor 161 isoform 4

    See identical proteins and their annotated locations for NP_001254541.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and lacks a portion of the 5' coding region compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (4) with a shorter N-terminus compared to isoform 1. Variants 5 and 11 both encode the same isoform (4).
    Source sequence(s)
    AA662800, AK056040, AL033532
    Consensus CDS
    CCDS58042.1
    UniProtKB/Swiss-Prot
    Q8N6U8
    Related
    ENSP00000356810.1, OTTHUMP00000032588, ENST00000367836.5, OTTHUMT00000083831
    Conserved Domains (2) summary
    cd14964
    Location:1430
    7tm_GPCRs; TM helix 4 [structural motif]
    cl28897
    Location:1203
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  5. NM_001267613.1NP_001254542.1  G-protein coupled receptor 161 isoform 5

    See identical proteins and their annotated locations for NP_001254542.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and lacks a portion of the 5' CDS compared to variant 1. These differences cause translation initiation an alternate start codon compared to variant 1. The resulting isoform (5) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AA662800, AK298797, AL033532
    Consensus CDS
    CCDS58044.1
    UniProtKB/Swiss-Prot
    Q8N6U8
    Related
    ENSP00000437576.1, ENST00000539777.5
    Conserved Domains (1) summary
    pfam00001
    Location:48246
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  6. NM_001267614.1NP_001254543.1  G-protein coupled receptor 161 isoform 6

    See identical proteins and their annotated locations for NP_001254543.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks a portion of the 5' coding region, initiates translation at an upstream start codon and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (6) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AA662800, AK298850, AL033532
    Consensus CDS
    CCDS58045.1
    UniProtKB/Swiss-Prot
    Q8N6U8
    Related
    ENSP00000444348.1, ENST00000546300.5
    Conserved Domains (1) summary
    pfam00001
    Location:12210
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  7. NM_001349632.1NP_001336561.1  G-protein coupled receptor 161 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variants 2, 3, 9, and 10, encodes isoform 2.
    Source sequence(s)
    AL033532
    Consensus CDS
    CCDS1268.1
    Conserved Domains (1) summary
    cd15214
    Location:29335
    7tmA_GPR161; orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors
  8. NM_001349633.1NP_001336562.1  G-protein coupled receptor 161 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variants 2, 3, 8, and 10, encodes isoform 2.
    Source sequence(s)
    AL033532
    Consensus CDS
    CCDS1268.1
    Conserved Domains (1) summary
    cd15214
    Location:29335
    7tmA_GPR161; orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors
  9. NM_001349634.1NP_001336563.1  G-protein coupled receptor 161 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variants 2, 3, 8, and 9, encodes isoform 2.
    Source sequence(s)
    AL033532
    Consensus CDS
    CCDS1268.1
    Conserved Domains (1) summary
    cd15214
    Location:29335
    7tmA_GPR161; orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors
  10. NM_001349635.1NP_001336564.1  G-protein coupled receptor 161 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variant 5, encodes isoform 4.
    Source sequence(s)
    AL033532
    Consensus CDS
    CCDS58042.1
    Conserved Domains (2) summary
    cd14964
    Location:1430
    7tm_GPCRs; TM helix 4 [structural motif]
    cl28897
    Location:1203
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  11. NM_153832.2NP_722561.1  G-protein coupled receptor 161 isoform 2

    See identical proteins and their annotated locations for NP_722561.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The resulting isoform (2) is shorter compared to isoform 1. Variants 2, 3, 8, 9, and 10 all encode the same isoform (2).
    Source sequence(s)
    AA662800, AL033532, BC028163
    Consensus CDS
    CCDS1268.1
    UniProtKB/Swiss-Prot
    Q8N6U8
    Related
    ENSP00000356812.1, OTTHUMP00000032586, ENST00000367838.5, OTTHUMT00000083829
    Conserved Domains (1) summary
    cd15214
    Location:29335
    7tmA_GPR161; orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    168079542..168137667 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509372.1XP_011507674.1  G-protein coupled receptor 161 isoform X2

    See identical proteins and their annotated locations for XP_011507674.1

    Conserved Domains (2) summary
    pfam00001
    Location:67347
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:58187
    7tm_4; Olfactory receptor
  2. XM_011509371.2XP_011507673.1  G-protein coupled receptor 161 isoform X2

    See identical proteins and their annotated locations for XP_011507673.1

    Conserved Domains (2) summary
    pfam00001
    Location:67347
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:58187
    7tm_4; Olfactory receptor
  3. XM_005245056.2XP_005245113.1  G-protein coupled receptor 161 isoform X4

    See identical proteins and their annotated locations for XP_005245113.1

    UniProtKB/Swiss-Prot
    Q8N6U8
    Conserved Domains (1) summary
    cd15214
    Location:29335
    7tmA_GPR161; orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors
  4. XM_011509378.1XP_011507680.1  G-protein coupled receptor 161 isoform X4

    See identical proteins and their annotated locations for XP_011507680.1

    UniProtKB/Swiss-Prot
    Q8N6U8
    Conserved Domains (1) summary
    cd15214
    Location:29335
    7tmA_GPR161; orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors
  5. XM_011509376.2XP_011507678.1  G-protein coupled receptor 161 isoform X4

    See identical proteins and their annotated locations for XP_011507678.1

    UniProtKB/Swiss-Prot
    Q8N6U8
    Conserved Domains (1) summary
    cd15214
    Location:29335
    7tmA_GPR161; orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors
  6. XM_011509373.2XP_011507675.1  G-protein coupled receptor 161 isoform X2

    See identical proteins and their annotated locations for XP_011507675.1

    Conserved Domains (2) summary
    pfam00001
    Location:67347
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:58187
    7tm_4; Olfactory receptor
  7. XM_005245055.2XP_005245112.1  G-protein coupled receptor 161 isoform X3

    See identical proteins and their annotated locations for XP_005245112.1

    UniProtKB/Swiss-Prot
    Q8N6U8
    Conserved Domains (2) summary
    pfam00001
    Location:64344
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:55184
    7tm_4; Olfactory receptor
  8. XM_006711251.1XP_006711314.1  G-protein coupled receptor 161 isoform X2

    See identical proteins and their annotated locations for XP_006711314.1

    Conserved Domains (2) summary
    pfam00001
    Location:67347
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:58187
    7tm_4; Olfactory receptor
  9. XM_005245057.4XP_005245114.1  G-protein coupled receptor 161 isoform X4

    See identical proteins and their annotated locations for XP_005245114.1

    UniProtKB/Swiss-Prot
    Q8N6U8
    Conserved Domains (1) summary
    cd15214
    Location:29335
    7tmA_GPR161; orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors
  10. XM_006711253.2XP_006711316.2  G-protein coupled receptor 161 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_007369.2: Suppressed sequence

    Description
    NM_007369.2: This RefSeq was suppressed because it mistakenly represents a partial CDS. The full-length CDS is represented in a different record (NM_153832).
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