Adprhl1 ADP-ribosylhydrolase like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adprhl1provided by MGI
Official Full Name: ADP-ribosylhydrolase like 1provided by MGI
Primary source: MGI:MGI:2442168
See related: Ensembl:ENSMUSG00000031448 AllianceGenome:MGI:2442168
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Arh2; Gm34595; D330008N11Rik
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity and intracellular protein transport. Orthologous to human ADPRHL1 (ADP-ribosylhydrolase like 1). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Annotation category: partial on reference assembly
Expression: Restricted expression toward heart adult (RPKM 27.0) See more
Orthologs: human all
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Genomic context

Location:: 8; 8 A1.1

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (13285632..13304694, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (13218788..13254542, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Defective heart chamber growth and myofibrillogenesis after knockout of adprhl1 gene function by targeted disruption of the ancestral catalytic active site.
Title: Defective heart chamber growth and myofibrillogenesis after knockout of adprhl1 gene function by targeted disruption of the ancestral catalytic active site.
Cardiac Adprhl1 expression is conserved in mammals, with Adprhl1 mRNA detected within embryonic mouse hearts at E11.5 and its expression may depend on the presence of the cardiac transcription factor, Nkx2-5.
Title: The cardiac-restricted protein ADP-ribosylhydrolase-like 1 is essential for heart chamber outgrowth and acts on muscle actin filament assembly.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the Adprhl1 gene: The Adprhl1 gene is conserved in human, dog, cow, rat, and zebrafish.
Orthologs from Annotation Pipeline: 456 organisms have orthologs with human gene Adprhl1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ADP-ribosylarginine hydrolase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein de-ADP-ribosylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: inactive ADP-ribosyltransferase ARH2; protein ADP-ribosylarginine hydrolase-like protein 1

Names: ADP-ribosylhydrolase 2; ADP-ribosylhydrolase-like protein 1; [Protein ADP-ribosylarginine] hydrolase-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001409003.1 → NP_001395932.1 inactive ADP-ribosyltransferase ARH2 isoform 2

Status: VALIDATED

Source sequence(s)

AC130818, AC133520
NM_001409005.1 → NP_001395934.1 inactive ADP-ribosyltransferase ARH2 isoform 3

Status: VALIDATED

Source sequence(s)

AC130818, AC133520

UniProtKB/TrEMBL

A0A0N4SVK8
NM_172750.5 → NP_766338.1 inactive ADP-ribosyltransferase ARH2 isoform 1

See identical proteins and their annotated locations for NP_766338.1

Status: VALIDATED

Source sequence(s)

AC130818, AC133520

Consensus CDS

CCDS22108.1

UniProtKB/Swiss-Prot

Q8BGK2, Q8C4L0

Related

ENSMUSP00000033825.5, ENSMUST00000033825.11

Conserved Domains (1) summary

pfam03747
Location:6 → 326

ADP_ribosyl_GH; ADP-ribosylglycohydrolase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

13285632..13304694 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)
NC_000074.7 Reference GRCm39 C57BL/6J

Range

13268449..13277517 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036153884.1 → XP_036009777.1 protein ADP-ribosylarginine hydrolase-like protein 1 isoform X1

Conserved Domains (1) summary

pfam03747
Location:6 → 271

ADP_ribosyl_GH; ADP-ribosylglycohydrolase