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ADPRHL1 ADP-ribosylhydrolase like 1 [ Homo sapiens (human) ]

Gene ID: 113622, updated on 25-Nov-2021

Summary

Official Symbol
ADPRHL1provided by HGNC
Official Full Name
ADP-ribosylhydrolase like 1provided by HGNC
Primary source
HGNC:HGNC:21303
See related
Ensembl:ENSG00000153531 MIM:610620
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARH2
Summary
ADP-ribosylation is a reversible posttranslational modification used to regulate protein function. ADP-ribosyltransferases (see ART1; MIM 601625) transfer ADP-ribose from NAD+ to the target protein, and ADP-ribosylhydrolases, such as ADPRHL1, reverse the reaction (Glowacki et al., 2002 [PubMed 12070318]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in heart (RPKM 98.4) and prostate (RPKM 3.2) See more
Orthologs
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Genomic context

See ADPRHL1 in Genome Data Viewer
Location:
13q34
Exon count:
12
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (113399607..113453488, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (114076260..114107803, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene lysosomal associated membrane protein 1 Neighboring gene growth hormone regulated TBC protein 1 Neighboring gene GRTP1 antisense RNA 1 Neighboring gene defective in cullin neddylation 1 domain containing 2 Neighboring gene RNA, U1 small nuclear 16, pseudogene Neighboring gene transmembrane and coiled-coil domains 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp451A211

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ADP-ribosylarginine hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cardiac chamber ballooning ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cardiac myofibril assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein de-ADP-ribosylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in sarcomere ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
[Protein ADP-ribosylarginine] hydrolase-like protein 1; protein ADP-ribosylarginine hydrolase-like protein 1
Names
ADP-ribosyl-hydrolase
ADP-ribosylarginine hydrolase like 1
ADP-ribosylhydrolase 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304433.1NP_001291362.1  [Protein ADP-ribosylarginine] hydrolase-like protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001291362.1

    Status: VALIDATED

    Description
    Transcript Variant: Variants 3 and 4 encode the same isoform (3).
    Source sequence(s)
    AL160251, BC036906, Z28716
    Conserved Domains (3) summary
    PTZ00121
    Location:12391444
    PTZ00121; MAEBL; Provisional
    PRK07764
    Location:7481142
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    pfam03157
    Location:11231547
    Glutenin_hmw; High molecular weight glutenin subunit
  2. NM_001375393.1NP_001362322.1  [Protein ADP-ribosylarginine] hydrolase-like protein 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: Variants 3 and 4 encode the same isoform (3).
    Source sequence(s)
    AL160251
    Related
    ENSP00000506851.1, ENST00000682618.1
    Conserved Domains (3) summary
    PTZ00121
    Location:12391444
    PTZ00121; MAEBL; Provisional
    PRK07764
    Location:7481142
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    pfam03157
    Location:11231547
    Glutenin_hmw; High molecular weight glutenin subunit
  3. NM_001394807.1NP_001381736.1  [Protein ADP-ribosylarginine] hydrolase-like protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL160251
    Conserved Domains (4) summary
    PRK07764
    Location:11121506
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    PRK09510
    Location:16051770
    tolA; cell envelope integrity inner membrane protein TolA; Provisional
    pfam03157
    Location:14791911
    Glutenin_hmw; High molecular weight glutenin subunit
    cl00614
    Location:2349
    ADP_ribosyl_GH; ADP-ribosylglycohydrolase
  4. NM_138430.5NP_612439.2  [Protein ADP-ribosylarginine] hydrolase-like protein 1 isoform 1

    See identical proteins and their annotated locations for NP_612439.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AJ313429, BC009755
    Consensus CDS
    CCDS9535.1
    UniProtKB/Swiss-Prot
    Q8NDY3
    Related
    ENSP00000364567.3, ENST00000375418.7
    Conserved Domains (1) summary
    pfam03747
    Location:6327
    ADP_ribosyl_GH; ADP-ribosylglycohydrolase
  5. NM_199162.3NP_954631.1  [Protein ADP-ribosylarginine] hydrolase-like protein 1 isoform 2

    See identical proteins and their annotated locations for NP_954631.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon and initiates translation at an in-frame downstream start codon compared to variant 1. The resulting isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AL160251, BC009755
    Consensus CDS
    CCDS9536.1
    UniProtKB/Swiss-Prot
    Q8NDY3
    Related
    ENSP00000348894.4, ENST00000356501.8
    Conserved Domains (1) summary
    pfam03747
    Location:35245
    ADP_ribosyl_GH; ADP-ribosylglycohydrolase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    113399607..113453488 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537461.2XP_011535763.1  protein ADP-ribosylarginine hydrolase-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011535763.1

    Conserved Domains (3) summary
    PTZ00121
    Location:12391444
    PTZ00121; MAEBL; Provisional
    PRK07764
    Location:7481142
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    pfam03157
    Location:11231547
    Glutenin_hmw; High molecular weight glutenin subunit

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001003399.1: Suppressed sequence

    Description
    NM_001003399.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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