U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

FRAT2 FRAT regulator of WNT signaling pathway 2 [ Homo sapiens (human) ]

Gene ID: 23401, updated on 5-Mar-2024

Summary

Official Symbol
FRAT2provided by HGNC
Official Full Name
FRAT regulator of WNT signaling pathway 2provided by HGNC
Primary source
HGNC:HGNC:16048
See related
Ensembl:ENSG00000181274 MIM:605006; AllianceGenome:HGNC:16048
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FRAT-2
Summary
The protein encoded by this intronless gene belongs to the GSK-3-binding protein family. Studies show that this protein plays a role as a positive regulator of the WNT signaling pathway. It may be upregulated in tumor progression. [provided by RefSeq, Jul 2008]
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Location:
10q24.1
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (97332497..97334729, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (98212697..98214929, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (99092254..99094486, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L12 pseudogene 27 Neighboring gene Sharpr-MPRA regulatory region 7927 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2671 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3847 Neighboring gene FRAT regulator of WNT signaling pathway 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3848 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:99093197-99094104 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2674 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2675 Neighboring gene uncharacterized LOC105378448 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2676 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:99096642-99097160 Neighboring gene ribosomal RNA processing 12 homolog Neighboring gene ribosomal protein L34 pseudogene 20

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC10562

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in beta-catenin destruction complex disassembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of protein export from nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
GSK-3-binding protein FRAT2
Names
FRAT2, WNT signaling pathway regulator
frequently rearranged in advanced T-cell lymphomas 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012083.3NP_036215.1  GSK-3-binding protein FRAT2

    See identical proteins and their annotated locations for NP_036215.1

    Status: REVIEWED

    Source sequence(s)
    AB045118, AL355490, BU675503, DR006612
    Consensus CDS
    CCDS7456.1
    UniProtKB/Swiss-Prot
    O75474, Q5JTI0, Q8WUL9, Q9BYG2
    UniProtKB/TrEMBL
    Q53XP8
    Related
    ENSP00000360058.2, ENST00000371019.4
    Conserved Domains (1) summary
    pfam05350
    Location:1211
    GSK-3_bind; Glycogen synthase kinase-3 binding

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    97332497..97334729 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    98212697..98214929 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)