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FRAT2 FRAT regulator of WNT signaling pathway 2 [ Homo sapiens (human) ]

Gene ID: 23401, updated on 21-Dec-2019

Summary

Official Symbol
FRAT2provided by HGNC
Official Full Name
FRAT regulator of WNT signaling pathway 2provided by HGNC
Primary source
HGNC:HGNC:16048
See related
Ensembl:ENSG00000181274 MIM:605006
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FRAT-2
Summary
The protein encoded by this intronless gene belongs to the GSK-3-binding protein family. Studies show that this protein plays a role as a positive regulator of the WNT signaling pathway. It may be upregulated in tumor progression. [provided by RefSeq, Jul 2008]
Orthologs

Genomic context

See FRAT2 in Genome Data Viewer
Location:
10q24.1
Exon count:
1
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (97332497..97334729, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (99092254..99094458, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L12 pseudogene 27 Neighboring gene FRAT regulator of WNT signaling pathway 1 Neighboring gene uncharacterized LOC105378448 Neighboring gene ribosomal RNA processing 12 homolog Neighboring gene ribosomal protein L34 pseudogene 20

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC10562

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
beta-catenin destruction complex disassembly TAS
Traceable Author Statement
more info
 
cell proliferation NAS
Non-traceable Author Statement
more info
PubMed 
multicellular organism development NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
GSK-3-binding protein FRAT2
Names
FRAT2, WNT signaling pathway regulator
frequently rearranged in advanced T-cell lymphomas 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012083.3NP_036215.1  GSK-3-binding protein FRAT2

    See identical proteins and their annotated locations for NP_036215.1

    Status: REVIEWED

    Source sequence(s)
    AB045118, AL355490, BU675503, DR006612
    Consensus CDS
    CCDS7456.1
    UniProtKB/Swiss-Prot
    O75474
    Related
    ENSP00000360058.2, ENST00000371019.4
    Conserved Domains (1) summary
    pfam05350
    Location:1211
    GSK-3_bind; Glycogen synthase kinase-3 binding

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    97332497..97334729 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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