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ADNP activity dependent neuroprotector homeobox [ Homo sapiens (human) ]

Gene ID: 23394, updated on 3-Sep-2017
Official Symbol
ADNPprovided by HGNC
Official Full Name
activity dependent neuroprotector homeoboxprovided by HGNC
Primary source
HGNC:HGNC:15766
See related
Ensembl:ENSG00000101126 MIM:611386; Vega:OTTHUMG00000032737
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ADNP1; HVDAS; MRD28
Summary
Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Orthologs
Location:
20q13.13
Exon count:
9
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 20 NC_000020.11 (50888918..50934984, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (49505585..49547527, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene par-6 family cell polarity regulator beta Neighboring gene breast carcinoma amplified sequence 4 Neighboring gene thymosin beta 4, X-linked pseudogene 6 Neighboring gene proteasome 26S subunit, non-ATPase, 10 pseudogene 1 Neighboring gene ADNP antisense RNA 1 Neighboring gene dolichyl-phosphate mannosyltransferase subunit 1, catalytic Neighboring gene molybdenum cofactor synthesis 3 Neighboring gene potassium voltage-gated channel modifier subfamily G member 1

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA0784

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
beta-tubulin binding IEA
Inferred from Electronic Annotation
more info
 
chromatin binding IEA
Inferred from Electronic Annotation
more info
 
copper ion binding IEA
Inferred from Electronic Annotation
more info
 
peptide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
activation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
cellular response to extracellular stimulus IEA
Inferred from Electronic Annotation
more info
 
estrous cycle IEA
Inferred from Electronic Annotation
more info
 
negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein binding IEA
Inferred from Electronic Annotation
more info
 
negative regulation of synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
nitric oxide homeostasis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of axon extension IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cGMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of synapse assembly IEA
Inferred from Electronic Annotation
more info
 
regulation of protein ADP-ribosylation IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
response to carbohydrate IEA
Inferred from Electronic Annotation
more info
 
response to inorganic substance IEA
Inferred from Electronic Annotation
more info
 
short-term memory IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
axon IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
dendrite IEA
Inferred from Electronic Annotation
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
activity-dependent neuroprotector homeobox protein
Names
ADNP homeobox 1
activity-dependent neuroprotective protein
activity-dependent neuroprotector

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034200.1 RefSeqGene

    Range
    4778..47073
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001282531.2NP_001269460.1  activity-dependent neuroprotector homeobox protein

    See identical proteins and their annotated locations for NP_001269460.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. All five variants encode the same protein.
    Source sequence(s)
    AF250860, AL034553, BM998017, DR006081
    Consensus CDS
    CCDS13433.1
    UniProtKB/Swiss-Prot
    Q9H2P0
    Related
    ENSP00000483881.1, ENST00000621696.4
    Conserved Domains (2) summary
    smart00389
    Location:768811
    HOX; Homeodomain
    sd00020
    Location:491510
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_001282532.1NP_001269461.1  activity-dependent neuroprotector homeobox protein

    See identical proteins and their annotated locations for NP_001269461.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. All five variants encode the same protein.
    Source sequence(s)
    AL034553, BC090933, BM998017
    Consensus CDS
    CCDS13433.1
    UniProtKB/Swiss-Prot
    Q9H2P0
    Related
    ENSP00000342905.3, OTTHUMP00000165329, ENST00000349014.7, OTTHUMT00000258382
    Conserved Domains (2) summary
    smart00389
    Location:768811
    HOX; Homeodomain
    sd00020
    Location:491510
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. NM_001347511.1NP_001334440.1  activity-dependent neuroprotector homeobox protein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 3. All five variants encode the same protein.
    Source sequence(s)
    AL034553, BC075794
    UniProtKB/Swiss-Prot
    Q9H2P0
    UniProtKB/TrEMBL
    Q6DHZ8
  4. NM_015339.4NP_056154.1  activity-dependent neuroprotector homeobox protein

    See identical proteins and their annotated locations for NP_056154.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. All five variants encode the same protein.
    Source sequence(s)
    AF250860, AL034553, BM998017
    Consensus CDS
    CCDS13433.1
    UniProtKB/Swiss-Prot
    Q9H2P0
    Related
    ENSP00000379346.3, OTTHUMP00000031276, ENST00000396029.7, OTTHUMT00000079705
    Conserved Domains (2) summary
    smart00389
    Location:768811
    HOX; Homeodomain
    sd00020
    Location:491510
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. NM_181442.3NP_852107.1  activity-dependent neuroprotector homeobox protein

    See identical proteins and their annotated locations for NP_852107.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. All five variants encode the same protein.
    Source sequence(s)
    AF250860, AL034553, AW452644, BM998017, DR006382
    Consensus CDS
    CCDS13433.1
    UniProtKB/Swiss-Prot
    Q9H2P0
    Related
    ENSP00000379349.2, OTTHUMP00000248633, ENST00000396032.7, OTTHUMT00000418977
    Conserved Domains (2) summary
    smart00389
    Location:768811
    HOX; Homeodomain
    sd00020
    Location:491510
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p7 Primary Assembly

    Range
    50888918..50934984 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027757.1XP_016883246.1  activity-dependent neuroprotector homeobox protein isoform X2

    Conserved Domains (2) summary
    smart00389
    Location:768811
    HOX; Homeodomain
    sd00020
    Location:491510
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. XM_011528747.2XP_011527049.1  activity-dependent neuroprotector homeobox protein isoform X2

    See identical proteins and their annotated locations for XP_011527049.1

    UniProtKB/Swiss-Prot
    Q9H2P0
    Conserved Domains (2) summary
    smart00389
    Location:768811
    HOX; Homeodomain
    sd00020
    Location:491510
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. XM_011528748.2XP_011527050.1  activity-dependent neuroprotector homeobox protein isoform X1

    Conserved Domains (2) summary
    smart00389
    Location:777820
    HOX; Homeodomain
    sd00020
    Location:500519
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. XM_017027759.1XP_016883248.1  activity-dependent neuroprotector homeobox protein isoform X2

    UniProtKB/Swiss-Prot
    Q9H2P0
    Conserved Domains (2) summary
    smart00389
    Location:768811
    HOX; Homeodomain
    sd00020
    Location:491510
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. XM_017027758.1XP_016883247.1  activity-dependent neuroprotector homeobox protein isoform X2

    UniProtKB/Swiss-Prot
    Q9H2P0
    Conserved Domains (2) summary
    smart00389
    Location:768811
    HOX; Homeodomain
    sd00020
    Location:491510
    ZF_C2H2; C2H2 Zn finger [structural motif]

Alternate CHM1_1.1

Genomic

  1. NC_018931.2 Alternate CHM1_1.1

    Range
    49410848..49452793 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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