Format

Send to:

Choose Destination

PPP1R13B protein phosphatase 1 regulatory subunit 13B [ Homo sapiens (human) ]

Gene ID: 23368, updated on 7-Oct-2018

Summary

Official Symbol
PPP1R13Bprovided by HGNC
Official Full Name
protein phosphatase 1 regulatory subunit 13Bprovided by HGNC
Primary source
HGNC:HGNC:14950
See related
Ensembl:ENSG00000088808 MIM:606455; Vega:OTTHUMG00000171647
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p85; ASPP1; p53BP2-like
Summary
This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. [provided by RefSeq, Jul 2008]
Expression
Broad expression in thyroid (RPKM 17.5), testis (RPKM 15.0) and 24 other tissues See more
Orthologs

Genomic context

See PPP1R13B in Genome Data Viewer
Location:
14q32.33
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (103733751..103849327, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (104200088..104315116, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984648 Neighboring gene X-ray repair cross complementing 3 Neighboring gene zinc finger FYVE-type containing 21 Neighboring gene long intergenic non-protein coding RNA 637 Neighboring gene uncharacterized LOC105370690 Neighboring gene uncharacterized LOC105370689 Neighboring gene ATP synthase membrane subunit 6.8PL

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of protein phosphatase 1, regulatory subunit 13B (PPP1R13B) in human B cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0771

Gene Ontology Provided by GOA

Function Evidence Code Pubs
p53 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
apoptosis-stimulating of p53 protein 1
Names
apoptosis-stimulating protein of p53, 1
protein phosphatase 1, regulatory (inhibitor) subunit 13B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046915.1 RefSeqGene

    Range
    6378..120217
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_015316.2NP_056131.2  apoptosis-stimulating of p53 protein 1

    See identical proteins and their annotated locations for NP_056131.2

    Status: REVIEWED

    Source sequence(s)
    AJ318887, AW295594, BC035446, DB461586
    Consensus CDS
    CCDS41997.1
    UniProtKB/Swiss-Prot
    Q96KQ4
    Related
    ENSP00000202556.9, OTTHUMP00000246651, ENST00000202556.13, OTTHUMT00000414591
    Conserved Domains (5) summary
    cd11954
    Location:10221078
    SH3_ASPP1; Src Homology 3 domain of Apoptosis Stimulating of p53 protein 1
    cd00204
    Location:8861009
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:892918
    ANK; ANK repeat [structural motif]
    cl25732
    Location:149317
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26464
    Location:445863
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

    Range
    103733751..103849327 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005267487.5XP_005267544.1  apoptosis-stimulating of p53 protein 1 isoform X2

    Conserved Domains (8) summary
    cd11954
    Location:10901146
    SH3_ASPP1; Src Homology 3 domain of Apoptosis Stimulating of p53 protein 1
    cd00204
    Location:9541077
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam06484
    Location:780936
    Ten_N; Teneurin Intracellular Region
    pfam07321
    Location:222385
    YscO; Type III secretion protein YscO
    pfam12796
    Location:9601046
    Ank_2; Ankyrin repeats (3 copies)
    pfam13863
    Location:221315
    DUF4200; Domain of unknown function (DUF4200)
    sd00045
    Location:960986
    ANK; ANK repeat [structural motif]
    cl09111
    Location:276386
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
  2. XM_011536593.3XP_011534895.1  apoptosis-stimulating of p53 protein 1 isoform X1

    Conserved Domains (8) summary
    cd11954
    Location:11251181
    SH3_ASPP1; Src Homology 3 domain of Apoptosis Stimulating of p53 protein 1
    cd00204
    Location:9891112
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam06484
    Location:857971
    Ten_N; Teneurin Intracellular Region
    pfam07321
    Location:222385
    YscO; Type III secretion protein YscO
    pfam12796
    Location:9951081
    Ank_2; Ankyrin repeats (3 copies)
    pfam13863
    Location:221315
    DUF4200; Domain of unknown function (DUF4200)
    sd00045
    Location:9951021
    ANK; ANK repeat [structural motif]
    cl09111
    Location:276386
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
  3. XM_017021116.1XP_016876605.1  apoptosis-stimulating of p53 protein 1 isoform X3

  4. XM_017021117.1XP_016876606.1  apoptosis-stimulating of p53 protein 1 isoform X4

  5. XM_017021119.1XP_016876608.1  apoptosis-stimulating of p53 protein 1 isoform X5

RNA

  1. XR_245676.4 RNA Sequence

  2. XR_943413.3 RNA Sequence

  3. XR_001750206.2 RNA Sequence

  4. XR_001750205.2 RNA Sequence

  5. XR_001750204.2 RNA Sequence

Support Center