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P2ry6 pyrimidinergic receptor P2Y, G-protein coupled, 6 [ Mus musculus (house mouse) ]

Gene ID: 233571, updated on 18-Dec-2022

Summary

Official Symbol
P2ry6provided by MGI
Official Full Name
pyrimidinergic receptor P2Y, G-protein coupled, 6provided by MGI
Primary source
MGI:MGI:2673874
See related
Ensembl:ENSMUSG00000048779 AllianceGenome:MGI:2673874
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P2Y6; 2010204J23Rik
Summary
Enables G protein-coupled UDP receptor activity. Acts upstream of or within cellular response to organic cyclic compound; cellular response to prostaglandin E stimulus; and transepithelial chloride transport. Predicted to be located in apical plasma membrane and basolateral plasma membrane. Is expressed in dermomyotome and musculature. Orthologous to human P2RY6 (pyrimidinergic receptor P2Y6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in colon adult (RPKM 37.0), lung adult (RPKM 23.5) and 16 other tissues See more
Orthologs
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Genomic context

See P2ry6 in Genome Data Viewer
Location:
7; 7 E2
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (100586837..100628528, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (100937630..100975498, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RELT tumor necrosis factor receptor Neighboring gene Rho guanine nucleotide exchange factor (GEF) 17 Neighboring gene microRNA 3102 Neighboring gene purinergic receptor P2Y, G-protein coupled 2 Neighboring gene ribosomal protein S29 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cellular response to organic cyclic compound IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to prostaglandin E stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to purine-containing compound ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to pyrimidine ribonucleotide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to pyrimidine ribonucleotide ISO
Inferred from Sequence Orthology
more info
 
involved_in phagocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of inositol trisphosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular associated smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within transepithelial chloride transport IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_183168.2NP_898991.1  P2Y purinoceptor 6

    See identical proteins and their annotated locations for NP_898991.1

    Status: VALIDATED

    Source sequence(s)
    AC151414
    Consensus CDS
    CCDS21507.1
    UniProtKB/Swiss-Prot
    Q9ERK9
    UniProtKB/TrEMBL
    Q3UQ86
    Related
    ENSMUSP00000055697.5, ENSMUST00000060174.6
    Conserved Domains (2) summary
    cd14964
    Location:2754
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:27312
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    100586837..100628528 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152995.1XP_036008888.1  P2Y purinoceptor 6 isoform X1

    UniProtKB/Swiss-Prot
    Q9ERK9
    UniProtKB/TrEMBL
    Q3UQ86
    Conserved Domains (2) summary
    cd14964
    Location:2754
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:27312
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  2. XM_011241739.4XP_011240041.1  P2Y purinoceptor 6 isoform X1

    See identical proteins and their annotated locations for XP_011240041.1

    UniProtKB/Swiss-Prot
    Q9ERK9
    UniProtKB/TrEMBL
    Q3UQ86
    Conserved Domains (2) summary
    cd14964
    Location:2754
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:27312
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  3. XM_006507640.4XP_006507703.1  P2Y purinoceptor 6 isoform X1

    See identical proteins and their annotated locations for XP_006507703.1

    UniProtKB/Swiss-Prot
    Q9ERK9
    UniProtKB/TrEMBL
    Q3UQ86
    Conserved Domains (2) summary
    cd14964
    Location:2754
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:27312
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily