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P2ry6 pyrimidinergic receptor P2Y, G-protein coupled, 6 [ Mus musculus (house mouse) ]

Gene ID: 233571, updated on 2-Nov-2024

Summary

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Official Symbol
P2ry6provided by MGI
Official Full Name
pyrimidinergic receptor P2Y, G-protein coupled, 6provided by MGI
Primary source
MGI:MGI:2673874
See related
Ensembl:ENSMUSG00000048779 AllianceGenome:MGI:2673874
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P2Y6; 2010204J23Rik
Summary
Enables G protein-coupled UDP receptor activity. Acts upstream of or within cellular response to organic cyclic compound; cellular response to prostaglandin E stimulus; and transepithelial chloride transport. Predicted to be located in apical plasma membrane and basolateral plasma membrane. Predicted to be active in plasma membrane. Is expressed in dermomyotome and musculature. Orthologous to human P2RY6 (pyrimidinergic receptor P2Y6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in colon adult (RPKM 37.0), lung adult (RPKM 23.5) and 16 other tissues See more
Orthologs
human all
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Genomic context

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See P2ry6 in Genome Data Viewer
Location:
7 E2; 7 54.46 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (100586837..100628528, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (100937630..100975498, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2834 Neighboring gene RELT tumor necrosis factor receptor Neighboring gene STARR-positive B cell enhancer ABC_E4955 Neighboring gene Rho guanine nucleotide exchange factor 17 Neighboring gene STARR-positive B cell enhancer ABC_E8191 Neighboring gene microRNA 3102 Neighboring gene STARR-seq mESC enhancer starr_19682 Neighboring gene STARR-seq mESC enhancer starr_19683 Neighboring gene STARR-seq mESC enhancer starr_19684 Neighboring gene STARR-seq mESC enhancer starr_19685 Neighboring gene purinergic receptor P2Y, G-protein coupled 2 Neighboring gene STARR-positive B cell enhancer ABC_E1348 Neighboring gene STARR-positive B cell enhancer ABC_E11362 Neighboring gene ribosomal protein S29 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Knockout mice reveal a role for P2Y6 receptor in macrophages, endothelial cells, and vascular smooth muscle cells. Bar I, et al. Mol Pharmacol, 2008 Sep. PMID 18523137
  2. Müller cell-mediated neurite outgrowth of the retinal ganglion cells via P2Y(6) receptor signals. Taguchi M, et al. J Neurochem, 2016 Feb. PMID 26560804
  3. Loss of Mouse P2Y6 Nucleotide Receptor Is Associated with Physiological Macrocardia and Amplified Pathological Cardiac Hypertrophy. Clouet S, et al. J Biol Chem, 2016 Jul 22. PMID 27231349, Free PMC Article
  4. P2Y receptors and atherosclerosis in apolipoprotein E-deficient mice. Guns PJ, et al. Br J Pharmacol, 2010 Jan 1. PMID 20050854, Free PMC Article
  5. P2Y6 contributes to ovalbumin-induced allergic asthma by enhancing mast cell function in mice. Shi JP, et al. Oncotarget, 2016 Sep 20. PMID 27590515, Free PMC Article

See all (73) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Microglial P2Y6 calcium signaling promotes phagocytosis and shapes neuroimmune responses in epileptogenesis.
    Title: Microglial P2Y(6) calcium signaling promotes phagocytosis and shapes neuroimmune responses in epileptogenesis.
  2. Macrophage P2Y6 receptor deletion attenuates atherosclerosis by limiting foam cell formation through phospholipase Cbeta/store-operated calcium entry/calreticulin/scavenger receptor A pathways.
    Title: Macrophage P2Y6 receptor deletion attenuates atherosclerosis by limiting foam cell formation through phospholipase Cβ/store-operated calcium entry/calreticulin/scavenger receptor A pathways.
  3. Knockout of Purinergic P2Y6 Receptor Fails to Improve Liver Injury and Inflammation in Non-Alcoholic Steatohepatitis.
    Title: Knockout of Purinergic P2Y(6) Receptor Fails to Improve Liver Injury and Inflammation in Non-Alcoholic Steatohepatitis.
  4. Macrophage P2Y6 Receptor Signaling Selectively Activates NFATC2 and Suppresses Allergic Lung Inflammation.
    Title: Macrophage P2Y6 Receptor Signaling Selectively Activates NFATC2 and Suppresses Allergic Lung Inflammation.
  5. P2RY6 Has a Critical Role in Mouse Skin Carcinogenesis by Regulating the YAP and beta-Catenin Signaling Pathways.
    Title: P2RY6 Has a Critical Role in Mouse Skin Carcinogenesis by Regulating the YAP and β-Catenin Signaling Pathways.
  6. Redox-dependent internalization of the purinergic P2Y6 receptor limits colitis progression.
    Title: Redox-dependent internalization of the purinergic P2Y(6) receptor limits colitis progression.
  7. Astrocyte-mediated purinergic signaling is upregulated in a mouse model of Fragile X syndrome.
    Title: Astrocyte-mediated purinergic signaling is upregulated in a mouse model of Fragile X syndrome.
  8. The microglial P2Y6 receptor mediates neuronal loss and memory deficits in neurodegeneration.
    Title: The microglial P2Y(6) receptor mediates neuronal loss and memory deficits in neurodegeneration.
  9. Inflammatory neuronal loss in the substantia nigra induced by systemic lipopolysaccharide is prevented by knockout of the P2Y6 receptor in mice.
    Title: Inflammatory neuronal loss in the substantia nigra induced by systemic lipopolysaccharide is prevented by knockout of the P2Y(6) receptor in mice.
  10. The UDP/P2y6 axis promotes lung metastasis of melanoma by remodeling the premetastatic niche.
    Title: The UDP/P2y6 axis promotes lung metastasis of melanoma by remodeling the premetastatic niche.
Submit: New GeneRIF Correction See all GeneRIFs (42)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled ADP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled ADP receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled ADP receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables G protein-coupled UDP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled UDP receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables G protein-coupled UDP receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables G protein-coupled UTP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled UTP receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled UTP receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables pyrimidine nucleotide binding IC
Inferred by Curator
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled purinergic nucleotide receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to organic cyclic compound IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cellular response to prostaglandin E stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to purine-containing compound IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to purine-containing compound ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to pyrimidine ribonucleotide IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to pyrimidine ribonucleotide IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to pyrimidine ribonucleotide ISO
Inferred from Sequence Orthology
more info
  
involved_in phagocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in phagocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of inositol trisphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of inositol trisphosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of smooth muscle cell migration IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of vascular associated smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of vascular associated smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within transepithelial chloride transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
P2Y purinoceptor 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_183168.2 → NP_898991.1  P2Y purinoceptor 6

    See identical proteins and their annotated locations for NP_898991.1

    Status: VALIDATED

    Source sequence(s)
    AC151414
    Consensus CDS
    CCDS21507.1
    UniProtKB/Swiss-Prot
    Q9ERK9
    UniProtKB/TrEMBL
    Q3UQ86
    Related
    ENSMUSP00000055697.5, ENSMUST00000060174.6
    Conserved Domains (2) summary
    cd14964
    Location:27 → 54
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:27 → 312
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    100586837..100628528 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152995.1 → XP_036008888.1  P2Y purinoceptor 6 isoform X1

    UniProtKB/Swiss-Prot
    Q9ERK9
    UniProtKB/TrEMBL
    Q3UQ86
    Conserved Domains (2) summary
    cd14964
    Location:27 → 54
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:27 → 312
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. XM_011241739.4 → XP_011240041.1  P2Y purinoceptor 6 isoform X1

    See identical proteins and their annotated locations for XP_011240041.1

    UniProtKB/Swiss-Prot
    Q9ERK9
    UniProtKB/TrEMBL
    Q3UQ86
    Conserved Domains (2) summary
    cd14964
    Location:27 → 54
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:27 → 312
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  3. XM_006507640.4 → XP_006507703.1  P2Y purinoceptor 6 isoform X1

    See identical proteins and their annotated locations for XP_006507703.1

    UniProtKB/Swiss-Prot
    Q9ERK9
    UniProtKB/TrEMBL
    Q3UQ86
    Conserved Domains (2) summary
    cd14964
    Location:27 → 54
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:27 → 312
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ERK9.1 GenPept UniProtKB/Swiss-Prot:Q9ERK9

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