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P2RY6 pyrimidinergic receptor P2Y6 [ Homo sapiens (human) ]

Gene ID: 5031, updated on 17-Jun-2019

Summary

Official Symbol
P2RY6provided by HGNC
Official Full Name
pyrimidinergic receptor P2Y6provided by HGNC
Primary source
HGNC:HGNC:8543
See related
Ensembl:ENSG00000171631 MIM:602451
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P2Y6
Summary
The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, which is a G-protein coupled receptor, is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. It is proposed that this receptor mediates inflammatory responses. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Mar 2013]
Expression
Biased expression in spleen (RPKM 4.4), placenta (RPKM 2.2) and 9 other tissues See more
Orthologs

Genomic context

See P2RY6 in Genome Data Viewer
Location:
11q13.4
Exon count:
7
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (73264503..73298625)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (72975550..73009670)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369382 Neighboring gene olfactory receptor family 8 subfamily R member 1 pseudogene Neighboring gene uncharacterized LOC100287837 Neighboring gene Rho guanine nucleotide exchange factor 17 Neighboring gene RELT TNF receptor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
  • Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
    Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • Nucleotide GPCRs, organism-specific biosystem (from WikiPathways)
    Nucleotide GPCRs, organism-specific biosystem
    Nucleotide GPCRs
  • Nucleotide-like (purinergic) receptors, organism-specific biosystem (from REACTOME)
    Nucleotide-like (purinergic) receptors, organism-specific biosystemPurinergic receptors (Burnstock G, 2006; Abbracchio MP et al, 2009) are a family of newly characterized plasma membrane molecules involved in several cellular functions such as vascular reactivity, a...
  • P2Y receptors, organism-specific biosystem (from REACTOME)
    P2Y receptors, organism-specific biosystemP2Y receptors are a family of purinergic receptors, G protein-coupled receptors stimulated by nucleotides such as ATP, ADP, UTP, UDP and UDP-glucose. To date, 12 P2Y receptors have been cloned in hum...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC15335

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ADP receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
G protein-coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
UDP-activated nucleotide receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
UTP-activated nucleotide receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled purinergic nucleotide receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
activation of phospholipase C activity TAS
Traceable Author Statement
more info
PubMed 
cellular response to prostaglandin E stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to purine-containing compound IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to pyrimidine ribonucleotide IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to pyrimidine ribonucleotide ISS
Inferred from Sequence or Structural Similarity
more info
 
phagocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
phospholipase C-activating G protein-coupled receptor signaling pathway IC
Inferred by Curator
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity TAS
Traceable Author Statement
more info
PubMed 
positive regulation of inositol trisphosphate biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of inositol trisphosphate biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
positive regulation of smooth muscle cell migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of vascular smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
transepithelial chloride transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IC
Inferred by Curator
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
P2Y purinoceptor 6
Names
G-coupled nucleotide receptor
P2 purinoceptor
P2Y6 receptor
pyrimidinergic receptor P2Y, G-protein coupled, 6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277204.1NP_001264133.1  P2Y purinoceptor 6 isoform 1

    See identical proteins and their annotated locations for NP_001264133.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1,2,3,5,6,7, and 8 encode the same isoform (1).
    Source sequence(s)
    AF218005, BC009391, DR004482, HY271000
    Consensus CDS
    CCDS8220.1
    UniProtKB/Swiss-Prot
    Q15077
    UniProtKB/TrEMBL
    A0A024R5I9
    Related
    ENSP00000442551.1, ENST00000540124.5
    Conserved Domains (1) summary
    cd15379
    Location:27312
    7tmA_P2Y6; P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001277205.1NP_001264134.1  P2Y purinoceptor 6 isoform 1

    See identical proteins and their annotated locations for NP_001264134.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1,2,3,5,6,7, and 8 encode the same isoform (1).
    Source sequence(s)
    AL525099, BC009391, BX397649, HY271000
    Consensus CDS
    CCDS8220.1
    UniProtKB/Swiss-Prot
    Q15077
    UniProtKB/TrEMBL
    A0A024R5I9
    Related
    ENSP00000445652.1, ENST00000542092.5
    Conserved Domains (1) summary
    cd15379
    Location:27312
    7tmA_P2Y6; P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. NM_001277206.1NP_001264135.1  P2Y purinoceptor 6 isoform 1

    See identical proteins and their annotated locations for NP_001264135.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1,2,3,5,6,7, and 8 encode the same isoform (1).
    Source sequence(s)
    AP002761, BC009391, BQ718871, HY271000
    Consensus CDS
    CCDS8220.1
    UniProtKB/Swiss-Prot
    Q15077
    UniProtKB/TrEMBL
    A0A024R5I9
    Related
    ENSP00000480966.1, ENST00000618468.4
    Conserved Domains (1) summary
    cd15379
    Location:27312
    7tmA_P2Y6; P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors
  4. NM_001277207.1NP_001264136.1  P2Y purinoceptor 6 isoform 1

    See identical proteins and their annotated locations for NP_001264136.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1,2,3,5,6,7, and 8 encode the same isoform (1).
    Source sequence(s)
    BC009391, BX337204, HY271000
    Consensus CDS
    CCDS8220.1
    UniProtKB/Swiss-Prot
    Q15077
    UniProtKB/TrEMBL
    A0A024R5I9
    Related
    ENSP00000443427.1, ENST00000540342.5
    Conserved Domains (1) summary
    cd15379
    Location:27312
    7tmA_P2Y6; P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors
  5. NM_001277208.1NP_001264137.1  P2Y purinoceptor 6 isoform 2

    See identical proteins and their annotated locations for NP_001264137.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) contains an alternate 5'-most exon and initiates translation at an alternate start codon so that the 5' UTR and 5' coding region differ compared to variant 1. The encoded isoform (2) has a longer N-terminus than isoform 1.
    Source sequence(s)
    BC009391, DR004482, HY271000
    UniProtKB/Swiss-Prot
    Q15077
    Conserved Domains (1) summary
    pfam00001
    Location:145401
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  6. NM_176796.2NP_789766.1  P2Y purinoceptor 6 isoform 1

    See identical proteins and their annotated locations for NP_789766.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1,2,3,5,6,7, and 8 encode the same isoform (1).
    Source sequence(s)
    BC009391, BX381745, BX397649, HY271000
    Consensus CDS
    CCDS8220.1
    UniProtKB/Swiss-Prot
    Q15077
    UniProtKB/TrEMBL
    A0A024R5I9
    Related
    ENSP00000309771.2, ENST00000349767.6
    Conserved Domains (1) summary
    cd15379
    Location:27312
    7tmA_P2Y6; P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors
  7. NM_176797.2NP_789767.1  P2Y purinoceptor 6 isoform 1

    See identical proteins and their annotated locations for NP_789767.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript. Variants 1,2,3,5,6,7, and 8 encode the same isoform (1).
    Source sequence(s)
    AF007891, BC009391, BX397649, HY271000
    Consensus CDS
    CCDS8220.1
    UniProtKB/Swiss-Prot
    Q15077
    UniProtKB/TrEMBL
    A0A024R5I9
    Related
    ENSP00000377217.2, ENST00000393592.6
    Conserved Domains (1) summary
    cd15379
    Location:27312
    7tmA_P2Y6; P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors
  8. NM_176798.2NP_789768.1  P2Y purinoceptor 6 isoform 1

    See identical proteins and their annotated locations for NP_789768.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1,2,3,5,6,7, and 8 encode the same isoform (1).
    Source sequence(s)
    AF007892, BC009391, DR006998, HY271000
    Consensus CDS
    CCDS8220.1
    UniProtKB/Swiss-Prot
    Q15077
    UniProtKB/TrEMBL
    A0A024R5I9
    Related
    ENSP00000377216.1, ENST00000393591.5
    Conserved Domains (1) summary
    cd15379
    Location:27312
    7tmA_P2Y6; P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    73264503..73298625
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545079.2XP_011543381.1  P2Y purinoceptor 6 isoform X2

    See identical proteins and their annotated locations for XP_011543381.1

    UniProtKB/Swiss-Prot
    Q15077
    UniProtKB/TrEMBL
    A0A024R5I9
    Conserved Domains (1) summary
    cd15379
    Location:27312
    7tmA_P2Y6; P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. XM_011545076.2XP_011543378.1  P2Y purinoceptor 6 isoform X1

    Conserved Domains (1) summary
    pfam00001
    Location:114370
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  3. XM_011545077.2XP_011543379.1  P2Y purinoceptor 6 isoform X2

    See identical proteins and their annotated locations for XP_011543379.1

    UniProtKB/Swiss-Prot
    Q15077
    UniProtKB/TrEMBL
    A0A024R5I9
    Conserved Domains (1) summary
    cd15379
    Location:27312
    7tmA_P2Y6; P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors
  4. XM_005274022.3XP_005274079.1  P2Y purinoceptor 6 isoform X2

    See identical proteins and their annotated locations for XP_005274079.1

    UniProtKB/Swiss-Prot
    Q15077
    UniProtKB/TrEMBL
    A0A024R5I9
    Related
    ENSP00000442990.1, ENST00000538328.1
    Conserved Domains (1) summary
    cd15379
    Location:27312
    7tmA_P2Y6; P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors
  5. XM_006718571.3XP_006718634.1  P2Y purinoceptor 6 isoform X2

    See identical proteins and their annotated locations for XP_006718634.1

    UniProtKB/Swiss-Prot
    Q15077
    UniProtKB/TrEMBL
    A0A024R5I9
    Conserved Domains (1) summary
    cd15379
    Location:27312
    7tmA_P2Y6; P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_004154.3: Suppressed sequence

    Description
    NM_004154.3: This RefSeq was permanently suppressed because it contains the wrong CDS (incomplete at the 5' end).
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