U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ANGEL1 angel homolog 1 [ Homo sapiens (human) ]

Gene ID: 23357, updated on 1-Mar-2024

Summary

Official Symbol
ANGEL1provided by HGNC
Official Full Name
angel homolog 1provided by HGNC
Primary source
HGNC:HGNC:19961
See related
Ensembl:ENSG00000013523 MIM:619537; AllianceGenome:HGNC:19961
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Ccr4e; KIAA0759
Summary
Enables eukaryotic initiation factor 4E binding activity and protein domain specific binding activity. Predicted to be involved in RNA phosphodiester bond hydrolysis, exonucleolytic. Located in several cellular components, including cis-Golgi network; endoplasmic reticulum; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 25.2), spleen (RPKM 10.7) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ANGEL1 in Genome Data Viewer
Location:
14q24.3
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (76786009..76812882, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (70995319..71022310, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (77252352..77279225, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370577 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8771 Neighboring gene MPRA-validated peak2205 silencer Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr14:77217211-77217770 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5957 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5958 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:77241882-77242840 Neighboring gene vasohibin 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8772 Neighboring gene VASH1 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:77278266-77278840 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:77278841-77279414 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr14:77288377-77289157 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:77294675-77295362 Neighboring gene Sharpr-MPRA regulatory region 2360 Neighboring gene leucine rich repeat containing 74A Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:77350573-77351390 Neighboring gene ribosomal protein L22 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370746.1NP_001357675.1  protein angel homolog 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AF111169
    Conserved Domains (1) summary
    cl00490
    Location:248449
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
  2. NM_001370747.1NP_001357676.1  protein angel homolog 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AF111169
    Conserved Domains (1) summary
    cl00490
    Location:248449
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
  3. NM_001370748.1NP_001357677.1  protein angel homolog 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AF111169
    Conserved Domains (1) summary
    cl00490
    Location:248449
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
  4. NM_015305.4NP_056120.2  protein angel homolog 1 isoform 4

    See identical proteins and their annotated locations for NP_056120.2

    Status: VALIDATED

    Source sequence(s)
    AF111169
    Consensus CDS
    CCDS9852.1
    UniProtKB/Swiss-Prot
    B4DWL7, O94859, Q8NCS9, Q9UNK9
    Related
    ENSP00000251089.3, ENST00000251089.8
    Conserved Domains (1) summary
    cl00490
    Location:248449
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    76786009..76812882 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    70995319..71022310 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)