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ANGEL1 angel homolog 1 [ Homo sapiens (human) ]

Gene ID: 23357, updated on 1-Jun-2020

Summary

Official Symbol
ANGEL1provided by HGNC
Official Full Name
angel homolog 1provided by HGNC
Primary source
HGNC:HGNC:19961
See related
Ensembl:ENSG00000013523
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Ccr4e; KIAA0759
Expression
Broad expression in testis (RPKM 25.2), spleen (RPKM 10.7) and 25 other tissues See more
Orthologs

Genomic context

See ANGEL1 in Genome Data Viewer
Location:
14q24.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (76786009..76812882, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (77248076..77292606, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370577 Neighboring gene vasohibin 1 Neighboring gene VASH1 antisense RNA 1 Neighboring gene leucine rich repeat containing 74A Neighboring gene ribosomal protein L22 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ60172

Gene Ontology Provided by GOA

Function Evidence Code Pubs
3'-5'-exoribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
eukaryotic initiation factor 4E binding IDA
Inferred from Direct Assay
more info
PubMed 
protein domain specific binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
RNA phosphodiester bond hydrolysis, exonucleolytic IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cis-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370746.1NP_001357675.1  protein angel homolog 1 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AF111169
    Conserved Domains (1) summary
    cl00490
    Location:248449
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
  2. NM_001370747.1NP_001357676.1  protein angel homolog 1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AF111169
    Conserved Domains (1) summary
    cl00490
    Location:248449
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
  3. NM_001370748.1NP_001357677.1  protein angel homolog 1 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AF111169
    Conserved Domains (1) summary
    cl00490
    Location:248449
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
  4. NM_015305.4NP_056120.2  protein angel homolog 1 isoform 4 precursor

    See identical proteins and their annotated locations for NP_056120.2

    Status: VALIDATED

    Source sequence(s)
    AF111169
    Consensus CDS
    CCDS9852.1
    UniProtKB/Swiss-Prot
    Q9UNK9
    UniProtKB/TrEMBL
    A0A024R6B2
    Related
    ENSP00000251089.2, ENST00000251089.7
    Conserved Domains (1) summary
    cl00490
    Location:248449
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    76786009..76812882 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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