Conserved Protein Domain Family

cl00490: EEP Superfamily (this model, PSSM-Id:294334 is obsolete and has been replaced by 351117)
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Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
This large superfamily includes the catalytic domain (exonuclease/endonuclease/phosphatase or EEP domain) of a diverse set of proteins including the ExoIII family of apurinic/apyrimidinic (AP) endonucleases, inositol polyphosphate 5-phosphatases (INPP5), neutral sphingomyelinases (nSMases), deadenylases (such as the vertebrate circadian-clock regulated nocturnin), bacterial cytolethal distending toxin B (CdtB), deoxyribonuclease 1 (DNase1), the endonuclease domain of the non-LTR retrotransposon LINE-1, and related domains. These diverse enzymes share a common catalytic mechanism of cleaving phosphodiester bonds; their substrates range from nucleic acids to phospholipids and perhaps proteins.
Taxonomy: root
PubMed: 477 links
Protein: Related Protein
Related Structure
Accession: cl00490
PSSM Id: 294334
Name: EEP
Created: 8-Feb-2008
Updated: 2-Feb-2016
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