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Picalm phosphatidylinositol binding clathrin assembly protein [ Mus musculus (house mouse) ]

Gene ID: 233489, updated on 21-May-2024

Summary

Official Symbol
Picalmprovided by MGI
Official Full Name
phosphatidylinositol binding clathrin assembly proteinprovided by MGI
Primary source
MGI:MGI:2385902
See related
Ensembl:ENSMUSG00000039361 AllianceGenome:MGI:2385902
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CALM; CLTH; fit1; fit-1; PAP180; mKIAA4114
Summary
Predicted to enable several functions, including SH3 domain binding activity; clathrin heavy chain binding activity; and phosphatidylinositol binding activity. Involved in several processes, including amyloid-beta clearance by transcytosis; neuron projection morphogenesis; and regulation of amyloid precursor protein catabolic process. Located in clathrin-coated pit and vesicle. Colocalizes with perinuclear region of cytoplasm. Is expressed in several structures, including aorta; heart; hemolymphoid system gland; liver; and lung. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human PICALM (phosphatidylinositol binding clathrin assembly protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 62.1), liver E14.5 (RPKM 55.2) and 28 other tissues See more
Orthologs
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Genomic context

See Picalm in Genome Data Viewer
Location:
7 D3; 7 50.47 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (89778711..89858655)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (90130192..90209447)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA E230029C05 gene Neighboring gene predicted gene, 32164 Neighboring gene RIKEN cDNA 2310010J17 gene Neighboring gene basic transcription factor 3, pseudogene 5 Neighboring gene STARR-positive B cell enhancer ABC_E4948 Neighboring gene STARR-positive B cell enhancer ABC_E3731 Neighboring gene coiled-coil domain containing 83 Neighboring gene STARR-seq mESC enhancer starr_19508 Neighboring gene synaptotagmin-like 2 Neighboring gene STARR-seq mESC enhancer starr_19509 Neighboring gene STARR-seq mESC enhancer starr_19510

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA4114, MGC19382, MGC36413, MGC36616

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 1-phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
 
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
 
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables SNARE binding ISO
Inferred from Sequence Orthology
more info
 
enables clathrin binding ISO
Inferred from Sequence Orthology
more info
 
enables clathrin heavy chain binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables clathrin heavy chain binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables low-density lipoprotein particle receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables phospholipid binding IEA
Inferred from Electronic Annotation
more info
 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
enables tau protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in amyloid-beta clearance by transcytosis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in amyloid-beta clearance by transcytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in amyloid-beta clearance by transcytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in axonogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in clathrin coat assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in clathrin-dependent endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in clathrin-dependent endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in clathrin-dependent endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dendrite morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in endosomal transport ISO
Inferred from Sequence Orthology
more info
 
involved_in hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular iron ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in learning or memory IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in membrane bending ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organismal-level iron ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of amyloid precursor protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of amyloid-beta formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of amyloid-beta formation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of axonogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dendrite extension ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synaptic vesicle clustering ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synaptic vesicle endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor internalization ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor-mediated endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of amyloid precursor protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in regulation of amyloid-beta formation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein localization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synaptic vesicle endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synaptic vesicle transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of terminal button organization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of vesicle size ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic vesicle budding from presynaptic endocytic zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in synaptic vesicle endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic vesicle maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vesicle budding from membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in vesicle cargo loading IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vesicle cargo loading ISO
Inferred from Sequence Orthology
more info
 
involved_in vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
is_active_in Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
part_of clathrin coat of coated pit ISO
Inferred from Sequence Orthology
more info
 
is_active_in clathrin-coated pit IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in clathrin-coated pit IDA
Inferred from Direct Assay
more info
PubMed 
located_in clathrin-coated pit ISO
Inferred from Sequence Orthology
more info
 
is_active_in clathrin-coated vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in clathrin-coated vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in endosome to plasma membrane transport vesicle ISO
Inferred from Sequence Orthology
more info
 
is_active_in extrinsic component of presynaptic endocytic zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in extrinsic component of presynaptic endocytic zone membrane ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in neurofibrillary tangle ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in parallel fiber to Purkinje cell synapse ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
phosphatidylinositol-binding clathrin assembly protein
Names
clathrin assembly lymphoid myeloid leukemia

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252520.3NP_001239449.1  phosphatidylinositol-binding clathrin assembly protein isoform 2

    See identical proteins and their annotated locations for NP_001239449.1

    Status: VALIDATED

    Source sequence(s)
    AC130210, AC158781
    Consensus CDS
    CCDS85335.1
    UniProtKB/TrEMBL
    Q570Z8
    Related
    ENSMUSP00000051092.9, ENSMUST00000049537.9
    Conserved Domains (2) summary
    pfam07651
    Location:19282
    ANTH; ANTH domain
    pfam08287
    Location:265344
    DASH_Spc19; Spc19
  2. NM_001252521.3NP_001239450.1  phosphatidylinositol-binding clathrin assembly protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC130210, AC158781
    Consensus CDS
    CCDS85334.1
    UniProtKB/TrEMBL
    Q570Z8
    Related
    ENSMUSP00000147016.2, ENSMUST00000208742.2
    Conserved Domains (2) summary
    pfam07651
    Location:19282
    ANTH; ANTH domain
    pfam08287
    Location:265344
    DASH_Spc19; Spc19
  3. NM_001252522.3NP_001239451.1  phosphatidylinositol-binding clathrin assembly protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC130210, AC158781
    Consensus CDS
    CCDS85336.1
    UniProtKB/TrEMBL
    Q570Z8
    Related
    ENSMUSP00000146386.2, ENSMUST00000209068.2
    Conserved Domains (2) summary
    pfam07651
    Location:19282
    ANTH; ANTH domain
    pfam08287
    Location:265344
    DASH_Spc19; Spc19
  4. NM_001252523.3NP_001239452.1  phosphatidylinositol-binding clathrin assembly protein isoform 5

    See identical proteins and their annotated locations for NP_001239452.1

    Status: VALIDATED

    Source sequence(s)
    AC130210, AC158781
    Consensus CDS
    CCDS85337.1
    UniProtKB/TrEMBL
    Q570Z8
    Related
    ENSMUSP00000146541.2, ENSMUST00000208730.2
    Conserved Domains (2) summary
    pfam07651
    Location:19282
    ANTH; ANTH domain
    pfam08287
    Location:265344
    DASH_Spc19; Spc19
  5. NM_001252524.3NP_001239453.1  phosphatidylinositol-binding clathrin assembly protein isoform 6

    See identical proteins and their annotated locations for NP_001239453.1

    Status: VALIDATED

    Source sequence(s)
    AC130210, AC158781
    Consensus CDS
    CCDS85338.1
    UniProtKB/TrEMBL
    Q3TD51, Q570Z8
    Related
    ENSMUSP00000146659.2, ENSMUST00000207225.2
    Conserved Domains (2) summary
    pfam07651
    Location:19282
    ANTH; ANTH domain
    pfam08287
    Location:265344
    DASH_Spc19; Spc19
  6. NM_001360867.2NP_001347796.1  phosphatidylinositol-binding clathrin assembly protein isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC130210, AC158781
    UniProtKB/TrEMBL
    Q570Z8
    Related
    ENSMUSP00000146509.2, ENSMUST00000207084.2
    Conserved Domains (2) summary
    COG4223
    Location:268366
    COG4223; Uncharacterized conserved protein [Function unknown]
    pfam07651
    Location:24282
    ANTH; ANTH domain
  7. NM_001420463.1NP_001407392.1  phosphatidylinositol-binding clathrin assembly protein isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC130210, AC158781
  8. NM_001420464.1NP_001407393.1  phosphatidylinositol-binding clathrin assembly protein isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC130210, AC158781
  9. NM_001420465.1NP_001407394.1  phosphatidylinositol-binding clathrin assembly protein isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC130210, AC158781
  10. NM_001420466.1NP_001407395.1  phosphatidylinositol-binding clathrin assembly protein isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC130210, AC158781
  11. NM_001420467.1NP_001407396.1  phosphatidylinositol-binding clathrin assembly protein isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC130210, AC158781
  12. NM_001420468.1NP_001407397.1  phosphatidylinositol-binding clathrin assembly protein isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC130210
  13. NM_146194.6NP_666306.2  phosphatidylinositol-binding clathrin assembly protein isoform 1

    See identical proteins and their annotated locations for NP_666306.2

    Status: VALIDATED

    Source sequence(s)
    AC130210, AC158781
    Consensus CDS
    CCDS52307.1
    UniProtKB/Swiss-Prot
    Q3TS04, Q7M6Y3, Q811P1, Q8BUF6, Q8CIH8, Q8R0A9, Q8R3E1, Q8VDN5, Q921L0
    UniProtKB/TrEMBL
    Q570Z8
    Related
    ENSMUSP00000146501.2, ENSMUST00000207484.2
    Conserved Domains (2) summary
    pfam07651
    Location:19282
    ANTH; ANTH domain
    pfam08287
    Location:265344
    DASH_Spc19; Spc19

RNA

  1. NR_185178.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC130210
  2. NR_185179.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC130210

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    89778711..89858655
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507594.5XP_006507657.1  phosphatidylinositol-binding clathrin assembly protein isoform X1

    UniProtKB/TrEMBL
    Q570Z8
    Conserved Domains (1) summary
    pfam07651
    Location:24283
    ANTH; ANTH domain
  2. XM_006507598.5XP_006507661.1  phosphatidylinositol-binding clathrin assembly protein isoform X5

    UniProtKB/TrEMBL
    Q570Z8
    Conserved Domains (1) summary
    pfam07651
    Location:24283
    ANTH; ANTH domain
  3. XM_006507596.5XP_006507659.1  phosphatidylinositol-binding clathrin assembly protein isoform X3

    UniProtKB/TrEMBL
    Q570Z8
    Conserved Domains (1) summary
    pfam07651
    Location:24283
    ANTH; ANTH domain
  4. XM_006507599.5XP_006507662.1  phosphatidylinositol-binding clathrin assembly protein isoform X6

    UniProtKB/TrEMBL
    Q570Z8
    Conserved Domains (1) summary
    pfam07651
    Location:24283
    ANTH; ANTH domain
  5. XM_006507600.5XP_006507663.1  phosphatidylinositol-binding clathrin assembly protein isoform X7

    UniProtKB/TrEMBL
    Q570Z8
    Conserved Domains (1) summary
    pfam07651
    Location:24283
    ANTH; ANTH domain
  6. XM_006507602.5XP_006507665.1  phosphatidylinositol-binding clathrin assembly protein isoform X10

    UniProtKB/TrEMBL
    Q570Z8
    Conserved Domains (2) summary
    COG4223
    Location:268366
    COG4223; Uncharacterized conserved protein [Function unknown]
    pfam07651
    Location:24283
    ANTH; ANTH domain
  7. XM_006507604.5XP_006507667.1  phosphatidylinositol-binding clathrin assembly protein isoform X12

    UniProtKB/TrEMBL
    Q570Z8
    Conserved Domains (2) summary
    COG4223
    Location:268366
    COG4223; Uncharacterized conserved protein [Function unknown]
    pfam07651
    Location:24283
    ANTH; ANTH domain
  8. XM_006507603.5XP_006507666.1  phosphatidylinositol-binding clathrin assembly protein isoform X11

    UniProtKB/TrEMBL
    Q570Z8
    Conserved Domains (2) summary
    COG4223
    Location:268366
    COG4223; Uncharacterized conserved protein [Function unknown]
    pfam07651
    Location:24283
    ANTH; ANTH domain
  9. XM_006507605.5XP_006507668.1  phosphatidylinositol-binding clathrin assembly protein isoform X13

    UniProtKB/TrEMBL
    Q570Z8
    Conserved Domains (2) summary
    COG4223
    Location:268366
    COG4223; Uncharacterized conserved protein [Function unknown]
    pfam07651
    Location:24283
    ANTH; ANTH domain