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DNAJC16 DnaJ heat shock protein family (Hsp40) member C16 [ Homo sapiens (human) ]

Gene ID: 23341, updated on 25-Jan-2022

Summary

Official Symbol
DNAJC16provided by HGNC
Official Full Name
DnaJ heat shock protein family (Hsp40) member C16provided by HGNC
Primary source
HGNC:HGNC:29157
See related
Ensembl:ENSG00000116138 AllianceGenome:HGNC:29157
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ERdj8
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in kidney (RPKM 7.4), thyroid (RPKM 5.5) and 25 other tissues See more
Orthologs
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Genomic context

See DNAJC16 in Genome Data Viewer
Location:
1p36.21
Exon count:
15
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (15526848..15571733)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (15853343..15898228)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene chymotrypsin like elastase 2B Neighboring gene caspase 9 Neighboring gene Sharpr-MPRA regulatory region 4011 Neighboring gene small Cajal body-specific RNA 21B Neighboring gene agmatinase Neighboring gene RNA, U7 small nuclear 179 pseudogene Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0962, DKFZp686G1298, DKFZp686N0387, DKFZp781I1547

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dnaJ homolog subfamily C member 16
Names
DnaJ (Hsp40) homolog, subfamily C, member 16
novel DnaJ domain-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001287811.2NP_001274740.1  dnaJ homolog subfamily C member 16 isoform 2

    See identical proteins and their annotated locations for NP_001274740.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in its 5' UTR, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AB023179, BC047363, CR749259
    Consensus CDS
    CCDS72710.1
    UniProtKB/Swiss-Prot
    Q9Y2G8
    Related
    ENSP00000480224.1, ENST00000616884.4
  2. NM_015291.4NP_056106.1  dnaJ homolog subfamily C member 16 isoform 1 precursor

    See identical proteins and their annotated locations for NP_056106.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AB023179, BC047363
    Consensus CDS
    CCDS30606.1
    UniProtKB/Swiss-Prot
    Q9Y2G8
    Related
    ENSP00000365007.3, ENST00000375847.8
    Conserved Domains (2) summary
    cd02963
    Location:136245
    TRX_DnaJ; TRX domain, DnaJ domain containing protein family; composed of uncharacterized proteins of about 500-800 amino acids, containing an N-terminal DnaJ domain followed by one redox active TRX domain. DnaJ is a member of the 40 kDa heat-shock protein (Hsp40) ...
    cl28246
    Location:29142
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

RNA

  1. NR_109898.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site at an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB023179, AL833299, BC047363
    Related
    ENST00000475133.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    15526848..15571733
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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