U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Kctd15 potassium channel tetramerisation domain containing 15 [ Mus musculus (house mouse) ]

Gene ID: 233107, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
Kctd15provided by MGI
Official Full Name
potassium channel tetramerisation domain containing 15provided by MGI
Primary source
MGI:MGI:2385276
See related
Ensembl:ENSMUSG00000030499 AllianceGenome:MGI:2385276
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in protein homooligomerization. Is expressed in several structures, including adrenal gland; esophagus; hemolymphoid system gland; nervous system; and respiratory system. Orthologous to human KCTD15 (potassium channel tetramerization domain containing 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in whole brain E14.5 (RPKM 20.1), CNS E14 (RPKM 19.4) and 24 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Kctd15 in Genome Data Viewer
Location:
7 B1- B2; 7 20.41 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (34336424..34354934, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (34636999..34655509, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12784 Neighboring gene STARR-seq mESC enhancer starr_18597 Neighboring gene STARR-seq mESC enhancer starr_18598 Neighboring gene predicted gene, 35378 Neighboring gene STARR-seq mESC enhancer starr_18604 Neighboring gene predicted gene, 57783 Neighboring gene predicted gene 12781

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The BTB-containing protein Kctd15 is SUMOylated in vivo. Zarelli VE, et al. PLoS One, 2013. PMID 24086424, Free PMC Article
  2. Obesity-linked homologues TfAP-2 and Twz establish meal frequency in Drosophila melanogaster. Williams MJ, et al. PLoS Genet, 2014 Sep. PMID 25187989, Free PMC Article
  3. The essential player in adipogenesis GRP78 is a novel KCTD15 interactor. Smaldone G, et al. Int J Biol Macromol, 2018 Aug. PMID 29665387
  4. Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene Expression. West DB, et al. PLoS Genet, 2016 Feb. PMID 26839965, Free PMC Article
  5. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the physiological role played by the complex KCTD15-GRP78 in the adipogenesis
    Title: The essential player in adipogenesis GRP78 is a novel KCTD15 interactor.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 
  • Targeted (3)  1 citation

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC25497

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
BTB/POZ domain-containing protein KCTD15
Names
potassium channel tetramerization domain-containing protein 15

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360818.2 → NP_001347747.1  BTB/POZ domain-containing protein KCTD15

    Status: VALIDATED

    Source sequence(s)
    BX649462
    Consensus CDS
    CCDS21141.1
    UniProtKB/Swiss-Prot
    Q8K0E1
    Related
    ENSMUSP00000032709.2, ENSMUST00000032709.3
    Conserved Domains (1) summary
    cd18388
    Location:55 → 153
    BTB_POZ_KCTD15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 15 (KCTD15)

  2. NM_001360820.2 → NP_001347749.1  BTB/POZ domain-containing protein KCTD15

    Status: VALIDATED

    Source sequence(s)
    BX649462
    Consensus CDS
    CCDS21141.1
    UniProtKB/Swiss-Prot
    Q8K0E1
    Related
    ENSMUSP00000103704.2, ENSMUST00000108069.8
    Conserved Domains (1) summary
    cd18388
    Location:55 → 153
    BTB_POZ_KCTD15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 15 (KCTD15)

  3. NM_001420858.1 → NP_001407787.1  BTB/POZ domain-containing protein KCTD15

    Status: VALIDATED

    Source sequence(s)
    BX649462
    UniProtKB/Swiss-Prot
    Q8K0E1

  4. NM_001420859.1 → NP_001407788.1  BTB/POZ domain-containing protein KCTD15

    Status: VALIDATED

    Source sequence(s)
    BX649462
    UniProtKB/Swiss-Prot
    Q8K0E1

  5. NM_001420860.1 → NP_001407789.1  BTB/POZ domain-containing protein KCTD15

    Status: VALIDATED

    Source sequence(s)
    BX649462
    UniProtKB/Swiss-Prot
    Q8K0E1

  6. NM_146188.2 → NP_666300.1  BTB/POZ domain-containing protein KCTD15

    See identical proteins and their annotated locations for NP_666300.1

    Status: VALIDATED

    Source sequence(s)
    AW124009, BC031749, BX649462
    Consensus CDS
    CCDS21141.1
    UniProtKB/Swiss-Prot
    Q8K0E1
    Related
    ENSMUSP00000103705.3, ENSMUST00000108070.9
    Conserved Domains (1) summary
    cd18388
    Location:55 → 153
    BTB_POZ_KCTD15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 15 (KCTD15)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    34336424..34354934 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539905.3 → XP_006539968.1  BTB/POZ domain-containing protein KCTD15 isoform X1

    See identical proteins and their annotated locations for XP_006539968.1

    UniProtKB/Swiss-Prot
    Q8K0E1
    Conserved Domains (1) summary
    cd18388
    Location:55 → 153
    BTB_POZ_KCTD15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 15 (KCTD15)

  2. XM_006539904.5 → XP_006539967.1  BTB/POZ domain-containing protein KCTD15 isoform X1

    See identical proteins and their annotated locations for XP_006539967.1

    UniProtKB/Swiss-Prot
    Q8K0E1
    Conserved Domains (1) summary
    cd18388
    Location:55 → 153
    BTB_POZ_KCTD15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 15 (KCTD15)

  3. XM_006539901.5 → XP_006539964.1  BTB/POZ domain-containing protein KCTD15 isoform X1

    See identical proteins and their annotated locations for XP_006539964.1

    UniProtKB/Swiss-Prot
    Q8K0E1
    Conserved Domains (1) summary
    cd18388
    Location:55 → 153
    BTB_POZ_KCTD15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 15 (KCTD15)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K0E1.1 GenPept UniProtKB/Swiss-Prot:Q8K0E1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools