Format

Send to:

Choose Destination

KCTD15 potassium channel tetramerization domain containing 15 [ Homo sapiens (human) ]

Gene ID: 79047, updated on 8-Dec-2018

Summary

Official Symbol
KCTD15provided by HGNC
Official Full Name
potassium channel tetramerization domain containing 15provided by HGNC
Primary source
HGNC:HGNC:23297
See related
Ensembl:ENSG00000153885 MIM:615240
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in skin (RPKM 22.8), endometrium (RPKM 7.8) and 21 other tissues See more
Orthologs

Genomic context

See KCTD15 in Genome Data Viewer
Location:
19q13.11
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (33795540..33815761)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (34287751..34306666)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein L21 pseudogene 131 Neighboring gene carbohydrate sulfotransferase 8 Neighboring gene RNA, 7SL, cytoplasmic 150, pseudogene Neighboring gene uncharacterized LOC105372371

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
NHGRI GWA Catalog
Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
NHGRI GWA Catalog
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2628, MGC25497

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
BTB/POZ domain-containing protein KCTD15
Names
potassium channel tetramerisation domain containing 15
potassium channel tetramerization domain-containing protein 15

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001129994.1NP_001123466.1  BTB/POZ domain-containing protein KCTD15 isoform 2

    See identical proteins and their annotated locations for NP_001123466.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site in the 3' coding region, compared to variant 1, that results in a frameshift. The resulting protein (isoform 2) has a longer and distinct C-terminus compared to isoform 1. Variants 2 and 3 both encode the same protein.
    Source sequence(s)
    AI741557, AK025590, AK027901, AK225793, BP339379, CX752088
    Consensus CDS
    CCDS46039.1
    UniProtKB/Swiss-Prot
    Q96SI1
    Conserved Domains (1) summary
    cl02518
    Location:58145
    BTB; BTB/POZ domain
  2. NM_001129995.1NP_001123467.1  BTB/POZ domain-containing protein KCTD15 isoform 2

    See identical proteins and their annotated locations for NP_001123467.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses a different splice site in the 5' UTR and in the 3' coding region, compared to variant 1, that results in a frameshift. The resulting protein (isoform 2) has a longer and distinct C-terminus compared to isoform 1. Variants 2 and 3 both encode the same protein.
    Source sequence(s)
    AC008556, AI741557, AK291465, BP339379
    Consensus CDS
    CCDS46039.1
    UniProtKB/Swiss-Prot
    Q96SI1
    Related
    ENSP00000467612.1, ENST00000589786.5
    Conserved Domains (1) summary
    cl02518
    Location:58145
    BTB; BTB/POZ domain
  3. NM_024076.2NP_076981.2  BTB/POZ domain-containing protein KCTD15 isoform 1

    See identical proteins and their annotated locations for NP_076981.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant represents the longest transcript yet it encodes the shorter protein (isoform 1).
    Source sequence(s)
    AC008556, AI741557, BP339379, CN301512
    Consensus CDS
    CCDS12434.1
    UniProtKB/Swiss-Prot
    Q96SI1
    Related
    ENSP00000284006.4, ENST00000284006.10
    Conserved Domains (1) summary
    cl02518
    Location:58145
    BTB; BTB/POZ domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    33795540..33815761
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027284.1XP_016882773.1  BTB/POZ domain-containing protein KCTD15 isoform X2

  2. XM_017027283.1XP_016882772.1  BTB/POZ domain-containing protein KCTD15 isoform X1

    UniProtKB/Swiss-Prot
    Q96SI1
    Conserved Domains (1) summary
    cl02518
    Location:58145
    BTB; BTB/POZ domain
  3. XM_011527298.2XP_011525600.1  BTB/POZ domain-containing protein KCTD15 isoform X1

    See identical proteins and their annotated locations for XP_011525600.1

    UniProtKB/Swiss-Prot
    Q96SI1
    Related
    ENSP00000464812.1, ENST00000588881.5
    Conserved Domains (1) summary
    cl02518
    Location:58145
    BTB; BTB/POZ domain
  4. XM_011527296.2XP_011525598.2  BTB/POZ domain-containing protein KCTD15 isoform X1

    Conserved Domains (1) summary
    cl02518
    Location:58145
    BTB; BTB/POZ domain
  5. XM_011527297.2XP_011525599.1  BTB/POZ domain-containing protein KCTD15 isoform X1

    See identical proteins and their annotated locations for XP_011525599.1

    UniProtKB/Swiss-Prot
    Q96SI1
    Conserved Domains (1) summary
    cl02518
    Location:58145
    BTB; BTB/POZ domain

RNA

  1. XR_935857.1 RNA Sequence

Support Center