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MGRN1 mahogunin ring finger 1 [ Homo sapiens (human) ]

Gene ID: 23295, updated on 27-Nov-2024

Summary

Official Symbol
MGRN1provided by HGNC
Official Full Name
mahogunin ring finger 1provided by HGNC
Primary source
HGNC:HGNC:20254
See related
Ensembl:ENSG00000102858 MIM:607559; AllianceGenome:HGNC:20254
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF156
Summary
Enables ubiquitin-protein transferase activity. Involved in endosome to lysosome transport; negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; and protein monoubiquitination. Located in several cellular components, including early endosome; endoplasmic reticulum; and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in spleen (RPKM 8.9), brain (RPKM 8.4) and 25 other tissues See more
Orthologs
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Genomic context

See MGRN1 in Genome Data Viewer
Location:
16p13.3
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (4624826..4690972)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (4654281..4720424)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (4674827..4740973)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene chromosome 16 open reading frame 96 Neighboring gene SUB1 pseudogene 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4635152-4635652 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4642470-4643270 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4644073-4644872 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4661103-4661738 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7154 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7155 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7156 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4665101-4665673 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7157 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4665674-4666245 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7158 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:4674556-4675086 Neighboring gene UBA like domain containing 1 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr16:4675087-4675616 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4676147-4676675 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4687274-4688238 Neighboring gene RNA, 7SL, cytoplasmic 850, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4697151-4697650 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4704147-4704648 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4704649-4705148 Neighboring gene Sharpr-MPRA regulatory region 2432 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4723069-4723658 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4723659-4724246 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4726242-4726864 Neighboring gene microRNA 6769a Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4732781-4733281 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:4740387-4740751 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10343 Neighboring gene hESC enhancers GRCh37_chr16:4743475-4743982 and GRCh37_chr16:4743983-4744490 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4745093-4745593 Neighboring gene nudix hydrolase 16 like 1 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr16:4763641-4764282 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr16:4764283-4764922 Neighboring gene ankyrin repeat and sterile alpha motif domain containing 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr16:4768049-4768651 and GRCh37_chr16:4768652-4769253 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7163 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7164

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA0544

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in endosome to lysosome transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in endosome to lysosome transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heart development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of smoothened signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein monoubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein polyubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein-containing complex assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in early endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
located_in extracellular exosome HDA PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in membrane HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
part_of ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase MGRN1
Names
RING finger protein 156
RING-type E3 ubiquitin transferase MGRN1
mahogunin RING finger protein 1
mahogunin ring finger 1, E3 ubiquitin protein ligase
probable E3 ubiquitin-protein ligase MGRN1
NP_001135761.2
NP_001135762.1
NP_001135763.2
NP_056061.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142289.3NP_001135761.2  E3 ubiquitin-protein ligase MGRN1 isoform 2

    See identical proteins and their annotated locations for NP_001135761.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC023830, DA590130, EF471397
    Consensus CDS
    CCDS59256.1
    UniProtKB/TrEMBL
    K7EPJ5
    Related
    ENSP00000468819.1, ENST00000588994.5
    Conserved Domains (3) summary
    PHA02929
    Location:232331
    PHA02929; N1R/p28-like protein; Provisional
    TIGR00599
    Location:273449
    rad18; DNA repair protein rad18
    pfam13920
    Location:274319
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
  2. NM_001142290.3NP_001135762.1  E3 ubiquitin-protein ligase MGRN1 isoform 3

    See identical proteins and their annotated locations for NP_001135762.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AB011116, AC023830, DA590130
    Consensus CDS
    CCDS45402.1
    UniProtKB/Swiss-Prot
    A4URL3, A4URL4, O60291, Q86W76
    UniProtKB/TrEMBL
    K7EPJ5
    Related
    ENSP00000382487.4, ENST00000399577.9
    Conserved Domains (2) summary
    PHA02929
    Location:232331
    PHA02929; N1R/p28-like protein; Provisional
    pfam13920
    Location:274319
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
  3. NM_001142291.3NP_001135763.2  E3 ubiquitin-protein ligase MGRN1 isoform 4

    See identical proteins and their annotated locations for NP_001135763.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon and uses an alternate splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (4) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC023830, DA590130, EF471398
    Consensus CDS
    CCDS45401.2
    UniProtKB/TrEMBL
    K7EPJ5
    Related
    ENSP00000393311.2, ENST00000415496.5
    Conserved Domains (3) summary
    PHA02929
    Location:232331
    PHA02929; N1R/p28-like protein; Provisional
    TIGR00599
    Location:273449
    rad18; DNA repair protein rad18
    pfam13920
    Location:274319
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
  4. NM_015246.4NP_056061.1  E3 ubiquitin-protein ligase MGRN1 isoform 1

    See identical proteins and their annotated locations for NP_056061.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC023830, BC050389, DA590130
    Consensus CDS
    CCDS42115.1
    UniProtKB/TrEMBL
    K7EPJ5
    Related
    ENSP00000262370.6, ENST00000262370.12
    Conserved Domains (2) summary
    cd16789
    Location:277317
    mRING-HC-C3HC5_MGRN1_like---blasttree; Modified RING finger, HC subclass (C3HC5-type), found in mahogunin RING finger protein 1 (MGRN1), RING finger protein 157 (RNF157) and similar proteins
    cl27165
    Location:232331
    PHA02929; N1R/p28-like protein; Provisional

RNA

  1. NR_102267.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC023830, AK299052

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    4624826..4690972
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    4654281..4720424
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)