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MGRN1 mahogunin ring finger 1 [ Homo sapiens (human) ]

Gene ID: 23295, updated on 11-Jun-2021

Summary

Official Symbol
MGRN1provided by HGNC
Official Full Name
mahogunin ring finger 1provided by HGNC
Primary source
HGNC:HGNC:20254
See related
Ensembl:ENSG00000102858 MIM:607559
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF156
Summary
Mahogunin (MGRN1) is a C3HC4 RING-containing protein with E3 ubiquitin ligase activity in vitro.[supplied by OMIM, Apr 2004]
Expression
Ubiquitous expression in spleen (RPKM 8.9), brain (RPKM 8.4) and 25 other tissues See more
Orthologs
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Genomic context

See MGRN1 in Genome Data Viewer
Location:
16p13.3
Exon count:
17
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (4624826..4690972)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (4674827..4740973)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene chromosome 16 open reading frame 96 Neighboring gene SUB1 pseudogene 3 Neighboring gene Sharpr-MPRA regulatory region 9899 Neighboring gene UBA like domain containing 1 Neighboring gene RNA, 7SL, cytoplasmic 850, pseudogene Neighboring gene microRNA 6769a Neighboring gene nudix hydrolase 16 like 1 Neighboring gene ankyrin repeat and sterile alpha motif domain containing 3 Neighboring gene Sharpr-MPRA regulatory region 8628 Neighboring gene dynein axonemal assembly factor 8 Neighboring gene zinc finger protein 500

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0544

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in early endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
located_in extracellular exosome HDA PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in membrane HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase MGRN1
Names
RING finger protein 156
RING-type E3 ubiquitin transferase MGRN1
mahogunin RING finger protein 1
mahogunin ring finger 1, E3 ubiquitin protein ligase
probable E3 ubiquitin-protein ligase MGRN1
NP_001135761.2
NP_001135762.1
NP_001135763.2
NP_056061.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142289.3NP_001135761.2  E3 ubiquitin-protein ligase MGRN1 isoform 2

    See identical proteins and their annotated locations for NP_001135761.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC023830, DA590130, EF471397
    Consensus CDS
    CCDS59256.1
    UniProtKB/Swiss-Prot
    O60291
    Related
    ENSP00000468819.1, ENST00000588994.5
    Conserved Domains (3) summary
    PHA02929
    Location:232331
    PHA02929; N1R/p28-like protein; Provisional
    TIGR00599
    Location:273449
    rad18; DNA repair protein rad18
    pfam13920
    Location:274319
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
  2. NM_001142290.3NP_001135762.1  E3 ubiquitin-protein ligase MGRN1 isoform 3

    See identical proteins and their annotated locations for NP_001135762.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AB011116, AC023830, DA590130
    Consensus CDS
    CCDS45402.1
    UniProtKB/Swiss-Prot
    O60291
    Related
    ENSP00000382487.4, ENST00000399577.9
    Conserved Domains (2) summary
    PHA02929
    Location:232331
    PHA02929; N1R/p28-like protein; Provisional
    pfam13920
    Location:274319
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
  3. NM_001142291.3NP_001135763.2  E3 ubiquitin-protein ligase MGRN1 isoform 4

    See identical proteins and their annotated locations for NP_001135763.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon and uses an alternate splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (4) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC023830, DA590130, EF471398
    Consensus CDS
    CCDS45401.2
    UniProtKB/Swiss-Prot
    O60291
    Related
    ENSP00000393311.2, ENST00000415496.5
    Conserved Domains (3) summary
    PHA02929
    Location:232331
    PHA02929; N1R/p28-like protein; Provisional
    TIGR00599
    Location:273449
    rad18; DNA repair protein rad18
    pfam13920
    Location:274319
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
  4. NM_015246.4NP_056061.1  E3 ubiquitin-protein ligase MGRN1 isoform 1

    See identical proteins and their annotated locations for NP_056061.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC023830, BC050389, DA590130
    Consensus CDS
    CCDS42115.1
    UniProtKB/Swiss-Prot
    O60291
    Related
    ENSP00000262370.6, ENST00000262370.12
    Conserved Domains (2) summary
    cd16789
    Location:277317
    mRING-HC-C3HC5_MGRN1_like---blasttree; Modified RING finger, HC subclass (C3HC5-type), found in mahogunin RING finger protein 1 (MGRN1), RING finger protein 157 (RNF157) and similar proteins
    cl27165
    Location:232331
    PHA02929; N1R/p28-like protein; Provisional

RNA

  1. NR_102267.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC023830, AK299052

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    4624826..4690972
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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