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CSTF2T cleavage stimulation factor subunit 2 tau variant [ Homo sapiens (human) ]

Gene ID: 23283, updated on 24-Nov-2020

Summary

Official Symbol
CSTF2Tprovided by HGNC
Official Full Name
cleavage stimulation factor subunit 2 tau variantprovided by HGNC
Primary source
HGNC:HGNC:17086
See related
Ensembl:ENSG00000177613 MIM:611968
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CstF-64T
Orthologs

Genomic context

See CSTF2T in Genome Data Viewer
Location:
10q21.1
Exon count:
1
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (51695486..51699595, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (53455246..53459355, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene protein kinase cGMP-dependent 1 Neighboring gene microRNA 605 Neighboring gene Ras suppressor protein 1 pseudogene 3 Neighboring gene PRKG1 antisense RNA 1 Neighboring gene dickkopf WNT signaling pathway inhibitor 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genetic analysis of the pathogenic molecular sub-phenotype interferon-alpha identifies multiple novel loci involved in systemic lupus erythematosus.
GeneReviews: Not available
Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0689, DKFZp434C1013

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
mRNA 3'-end processing TAS
Traceable Author Statement
more info
 
mRNA splicing, via spliceosome TAS
Traceable Author Statement
more info
 
pre-mRNA cleavage required for polyadenylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
termination of RNA polymerase II transcription TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
mRNA cleavage and polyadenylation specificity factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
cleavage stimulation factor subunit 2 tau variant
Names
CF-1 64 kDa subunit tau
CSTF 64 kDa subunit tau
cleavage stimulation factor 64 kDa subunit tau
cleavage stimulation factor subunit 2, tau
cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau
cleavage stimulation factor, 3' pre-RNA, subunit 2, tau
tauCstF-64

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015235.3NP_056050.1  cleavage stimulation factor subunit 2 tau variant

    See identical proteins and their annotated locations for NP_056050.1

    Status: VALIDATED

    Source sequence(s)
    AB014589, AL136747, BI962669, BU743103, BX455090
    Consensus CDS
    CCDS7245.1
    UniProtKB/Swiss-Prot
    Q9H0L4
    Related
    ENSP00000332444.4, ENST00000331173.6
    Conserved Domains (4) summary
    COG0724
    Location:16109
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12671
    Location:1892
    RRM_CSTF2_CSTF2T; RNA recognition motif in cleavage stimulation factor subunit 2 (CSTF2), cleavage stimulation factor subunit 2 tau variant (CSTF2T) and similar proteins
    pfam14304
    Location:572612
    CSTF_C; Transcription termination and cleavage factor C-terminal
    pfam14327
    Location:113191
    CSTF2_hinge; Hinge domain of cleavage stimulation factor subunit 2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    51695486..51699595 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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