Cstf2t cleavage stimulation factor, 3' pre-RNA subunit 2, tau [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cstf2tprovided by MGI
Official Full Name: cleavage stimulation factor, 3' pre-RNA subunit 2, tauprovided by MGI
Primary source: MGI:MGI:1932622
See related: Ensembl:ENSMUSG00000053536 AllianceGenome:MGI:1932622
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 64kDa; tCstF-64; tauCstF-64
Summary: Enables RNA binding activity. Predicted to be involved in pre-mRNA cleavage required for polyadenylation. Predicted to act upstream of or within mRNA polyadenylation. Predicted to be located in nucleoplasm. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Is expressed in brain and spinal cord. Orthologous to human CSTF2T (cleavage stimulation factor subunit 2 tau variant). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: 19; 19 C1

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (31060241..31063992)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (31082841..31086592)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cstf2t may control other reproductive functions that are not directly linked to the formation of 3' ends of mature polyadenylated mRNAs during male germ cell formation.
Title: Cstf2t Regulates expression of histones and histone-like proteins in male germ cells.
Cstf2t Polyadenylation Gene Plays a Sex-Specific Role in Learning Behaviors in Mice
Title: The Cstf2t Polyadenylation Gene Plays a Sex-Specific Role in Learning Behaviors in Mice.
This demonstrates that tauCstF-64 is an important stage-specific regulator of Crem mRNA processing that modulates the spatial and temporal expression of downstream stage-specific genes necessary for the proper development of sperm in mice.
Title: TauCstF-64 Mediates Correct mRNA Polyadenylation and Splicing of Activator and Repressor Isoforms of the Cyclic AMP-Responsive Element Modulator (CREM) in Mouse Testis.
The results suggest that tauCstF-64 plays a role in 3' end determination and transcription termination for a large range of germ cell-expressed genes.
Title: The τCstF-64 polyadenylation protein controls genome expression in testis.
primarily supports spermatogenesis, but only incidently supports immune cell function
Title: Spermatogenetic but not immunological defects in mice lacking the τCstF-64 polyadenylation protein.
tauCstF-64 is required not only for expression of genes involved in morphological differentiation of spermatids but also for genes having products that function during interaction of motile spermatozoa with eggs.
Title: Infertility with impaired zona pellucida adhesion of spermatozoa from mice lacking TauCstF-64.
The Cstf2t protein contributes to proteomic diversity by regulating alternative polyadenylation of neural mRNAs.
Title: A family of splice variants of CstF-64 expressed in vertebrate nervous systems.
Targeted disruption of Cstf2t in mice causes aberrant spermatogenesis, specifically disrupting meiotic and postmeiotic development, resulting in male infertility resembling oligoasthenoteratozoospermia.
Title: Loss of polyadenylation protein tauCstF-64 causes spermatogenic defects and male infertility.
These results suggest the hypothesis that tauCstF-64 mRNA is regulated at the translational or post-translational level.
Title: The mRNA encoding tauCstF-64 is expressed ubiquitously in mouse tissues.
tauCstF-64 promotes germ-cell-specific patterns of polyadenylation by binding to different downstream sequence elements.
Title: Polyadenylation proteins CstF-64 and tauCstF-64 exhibit differential binding affinities for RNA polymers.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Cstf2t (e-PCR), detects polymorphism
- UniSTS:478995

RH126283 (e-PCR)
- UniSTS:162991

Homology

Homologs of the Cstf2t gene: The Cstf2t gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, and rat.
Orthologs from Annotation Pipeline: 186 organisms have orthologs with human gene Cstf2t
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mRNA 3'-end processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mRNA polyadenylation	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in pre-mRNA cleavage required for polyadenylation	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
part_of mRNA cleavage and polyadenylation specificity factor complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cleavage stimulation factor subunit 2 tau variant

Names: CF-1 64 kDa subunit, tau; CSTF 64 kDa subunit, tau; cleavage stimulation factor 64 kDa subunit, tau; cleavage stimulation factor subunit 2 tau; cleavage stimulation factor, 3' pre-RNA subunit 2, 64 kDa, tau

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031249.2 → NP_112539.2 cleavage stimulation factor subunit 2 tau variant

See identical proteins and their annotated locations for NP_112539.2

Status: VALIDATED

Source sequence(s)

AK082910, BY637182, CJ182579

Consensus CDS

CCDS37958.1

UniProtKB/Swiss-Prot

Q8C7E9, Q9EPU3

Related

ENSMUSP00000093831.4, ENSMUST00000066039.8

Conserved Domains (4) summary

COG0724
Location:16 → 109

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12671
Location:18 → 92

RRM_CSTF2_CSTF2T; RNA recognition motif in cleavage stimulation factor subunit 2 (CSTF2), cleavage stimulation factor subunit 2 tau variant (CSTF2T) and similar proteins

pfam14304
Location:588 → 628

CSTF_C; Transcription termination and cleavage factor C-terminal

pfam14327
Location:113 → 191

CSTF2_hinge; Hinge domain of cleavage stimulation factor subunit 2