Format

Send to:

Choose Destination

KLHL18 kelch like family member 18 [ Homo sapiens (human) ]

Gene ID: 23276, updated on 10-Oct-2019

Summary

Official Symbol
KLHL18provided by HGNC
Official Full Name
kelch like family member 18provided by HGNC
Primary source
HGNC:HGNC:29120
See related
Ensembl:ENSG00000114648
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in bone marrow (RPKM 6.1), skin (RPKM 5.8) and 25 other tissues See more
Orthologs

Genomic context

See KLHL18 in Genome Data Viewer
Location:
3p21.31
Exon count:
10
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (47282940..47346816)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (47324116..47388306)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene KIF9 antisense RNA 1 Neighboring gene kinesin family member 9 Neighboring gene small nucleolar RNA, C/D box 13 pseudogene 3 Neighboring gene small nucleolar RNA, C/D box 13J Neighboring gene protein tyrosine phosphatase non-receptor type 23 Neighboring gene SREBF chaperone Neighboring gene uncharacterized LOC105377073

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13703, FLJ61265, KIAA0795

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
positive regulation of mitotic cell cycle phase transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025010.5NP_079286.2  kelch-like protein 18

    See identical proteins and their annotated locations for NP_079286.2

    Status: VALIDATED

    Source sequence(s)
    AC104447
    Consensus CDS
    CCDS33749.1
    UniProtKB/Swiss-Prot
    O94889
    UniProtKB/TrEMBL
    A0A024R2T4
    Related
    ENSP00000232766.5, ENST00000232766.6
    Conserved Domains (6) summary
    smart00612
    Location:384430
    Kelch; Kelch domain
    PHA03098
    Location:34552
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:326369
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:28131
    BTB; BTB/POZ domain
    pfam01344
    Location:325370
    Kelch_1; Kelch motif
    pfam07707
    Location:140242
    BACK; BTB And C-terminal Kelch

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    47282940..47346816
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005265001.3XP_005265058.2  kelch-like protein 18 isoform X1

    Conserved Domains (6) summary
    smart00612
    Location:394440
    Kelch; Kelch domain
    PHA03098
    Location:34562
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:331374
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:28131
    BTB; BTB/POZ domain
    pfam01344
    Location:330375
    Kelch_1; Kelch motif
    pfam07707
    Location:140242
    BACK; BTB And C-terminal Kelch
  2. XM_005265003.3XP_005265060.2  kelch-like protein 18 isoform X3

    Conserved Domains (6) summary
    smart00612
    Location:389435
    Kelch; Kelch domain
    PHA03098
    Location:34557
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:326369
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:28131
    BTB; BTB/POZ domain
    pfam01344
    Location:325370
    Kelch_1; Kelch motif
    pfam07707
    Location:140242
    BACK; BTB And C-terminal Kelch
  3. XM_005265002.5XP_005265059.2  kelch-like protein 18 isoform X2

    Conserved Domains (6) summary
    smart00612
    Location:389435
    Kelch; Kelch domain
    PHA03098
    Location:34557
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:331374
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:28131
    BTB; BTB/POZ domain
    pfam01344
    Location:330375
    Kelch_1; Kelch motif
    pfam07707
    Location:140242
    BACK; BTB And C-terminal Kelch
  4. XM_017006033.1XP_016861522.1  kelch-like protein 18 isoform X4

  5. XM_017006034.1XP_016861523.1  kelch-like protein 18 isoform X5

  6. XM_017006035.1XP_016861524.1  kelch-like protein 18 isoform X6

    UniProtKB/TrEMBL
    B4DHW4
    Conserved Domains (4) summary
    smart00612
    Location:272318
    Kelch; Kelch domain
    sd00038
    Location:214257
    Kelch; KELCH repeat [structural motif]
    pfam01344
    Location:401445
    Kelch_1; Kelch motif
    pfam07707
    Location:28130
    BACK; BTB And C-terminal Kelch
Support Center