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MGA MAX dimerization protein MGA [ Homo sapiens (human) ]

Gene ID: 23269, updated on 23-Sep-2022

Summary

Official Symbol
MGAprovided by HGNC
Official Full Name
MAX dimerization protein MGAprovided by HGNC
Primary source
HGNC:HGNC:14010
See related
Ensembl:ENSG00000174197 MIM:616061; AllianceGenome:HGNC:14010
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MAD5; MXD5
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell fate specification and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Part of MLL1 complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 5.9), testis (RPKM 5.5) and 25 other tissues See more
Orthologs
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Genomic context

See MGA in Genome Data Viewer
Location:
15q15.1
Exon count:
28
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (41621224..41769940)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (39427379..39575822)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (41913422..42062138)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene TYRO3 protein tyrosine kinase Neighboring gene uncharacterized LOC105370791 Neighboring gene small nucleolar RNA U3 Neighboring gene microRNA 626 Neighboring gene mitogen-activated protein kinase binding protein 1 Neighboring gene JMJD7-PLA2G4B readthrough Neighboring gene Sharpr-MPRA regulatory region 5929 Neighboring gene jumonji domain containing 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12634, KIAA0518

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cell fate specification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of MLL1 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of MLL1 complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
MAX gene-associated protein
Names
MAX dimerization protein 5
MGA, MAX dimerization protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080541.3NP_001074010.2  MAX gene-associated protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AA188751, AB011090, AC016134, AC073657, BC136659, BQ937819, BX643019, DC391039, DR001080
    Consensus CDS
    CCDS55960.1
    UniProtKB/Swiss-Prot
    Q8IWI9
    UniProtKB/TrEMBL
    B9EGR5
    Related
    ENSP00000456141.1, ENST00000566586.6
    Conserved Domains (3) summary
    cd00182
    Location:74264
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
    pfam00010
    Location:22162266
    HLH; Helix-loop-helix DNA-binding domain
    pfam16059
    Location:10411087
    DUF4801; Domain of unknown function (DUF4801)
  2. NM_001164273.2NP_001157745.1  MAX gene-associated protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC016134, AC073657
    Consensus CDS
    CCDS55959.1
    UniProtKB/Swiss-Prot
    Q8IWI9, Q9Y4E9
    Related
    ENSP00000219905.7, ENST00000219905.13
    Conserved Domains (5) summary
    cd00182
    Location:74264
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
    pfam03154
    Location:16891983
    Atrophin-1; Atrophin-1 family
    pfam16059
    Location:10411083
    DUF4801; Domain of unknown function (DUF4801)
    pfam17823
    Location:14691771
    DUF5585; Family of unknown function (DUF5585)
    cd18911
    Location:24252489
    bHLHzip_MGA; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and similar proteins
  3. NM_001400225.1NP_001387154.1  MAX gene-associated protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC016134, AC073657
  4. NM_001400242.1NP_001387171.1  MAX gene-associated protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC016134, AC073657
  5. NM_001400243.1NP_001387172.1  MAX gene-associated protein isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC016134, AC073657
    Related
    ENST00000682463.1
  6. NM_001400244.1NP_001387173.1  MAX gene-associated protein isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC016134, AC073657
  7. NM_001400245.1NP_001387174.1  MAX gene-associated protein isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC016134, AC073657
  8. NM_001400246.1NP_001387175.1  MAX gene-associated protein isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC016134, AC073657
  9. NM_001400247.1NP_001387176.1  MAX gene-associated protein isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC016134, AC073657

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    41621224..41769940
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022029.3XP_016877518.1  MAX gene-associated protein isoform X16

    Conserved Domains (2) summary
    pfam00010
    Location:20182068
    HLH; Helix-loop-helix DNA-binding domain
    pfam16059
    Location:584630
    DUF4801; Domain of unknown function (DUF4801)
  2. XM_047432300.1XP_047288256.1  MAX gene-associated protein isoform X18

  3. XM_047432302.1XP_047288258.1  MAX gene-associated protein isoform X19

  4. XM_005254246.4XP_005254303.1  MAX gene-associated protein isoform X1

    See identical proteins and their annotated locations for XP_005254303.1

    Conserved Domains (3) summary
    cd00182
    Location:74264
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
    pfam00010
    Location:24752525
    HLH; Helix-loop-helix DNA-binding domain
    pfam16059
    Location:10411087
    DUF4801; Domain of unknown function (DUF4801)
  5. XM_047432276.1XP_047288232.1  MAX gene-associated protein isoform X2

    Related
    ENSP00000457035.2, ENST00000570161.6
  6. XM_047432286.1XP_047288242.1  MAX gene-associated protein isoform X9

  7. XM_047432288.1XP_047288244.1  MAX gene-associated protein isoform X10

  8. XM_047432279.1XP_047288235.1  MAX gene-associated protein isoform X3

  9. XM_047432280.1XP_047288236.1  MAX gene-associated protein isoform X4

    UniProtKB/Swiss-Prot
    Q9Y4E9
  10. XM_047432291.1XP_047288247.1  MAX gene-associated protein isoform X12

  11. XM_047432281.1XP_047288237.1  MAX gene-associated protein isoform X6

  12. XM_047432295.1XP_047288251.1  MAX gene-associated protein isoform X14

  13. XM_047432298.1XP_047288254.1  MAX gene-associated protein isoform X15

  14. XM_006720445.5XP_006720508.1  MAX gene-associated protein isoform X16

    Conserved Domains (2) summary
    pfam00010
    Location:20182068
    HLH; Helix-loop-helix DNA-binding domain
    pfam16059
    Location:584630
    DUF4801; Domain of unknown function (DUF4801)
  15. XM_047432299.1XP_047288255.1  MAX gene-associated protein isoform X17

  16. XM_047432305.1XP_047288261.1  MAX gene-associated protein isoform X22

  17. XM_047432306.1XP_047288262.1  MAX gene-associated protein isoform X23

  18. XM_047432301.1XP_047288257.1  MAX gene-associated protein isoform X19

  19. XM_047432307.1XP_047288263.1  MAX gene-associated protein isoform X24

  20. XM_047432303.1XP_047288259.1  MAX gene-associated protein isoform X20

  21. XM_047432308.1XP_047288264.1  MAX gene-associated protein isoform X25

  22. XM_047432304.1XP_047288260.1  MAX gene-associated protein isoform X21

  23. XM_005254243.4XP_005254300.1  MAX gene-associated protein isoform X1

    See identical proteins and their annotated locations for XP_005254300.1

    Conserved Domains (3) summary
    cd00182
    Location:74264
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
    pfam00010
    Location:24752525
    HLH; Helix-loop-helix DNA-binding domain
    pfam16059
    Location:10411087
    DUF4801; Domain of unknown function (DUF4801)
  24. XM_005254253.4XP_005254310.1  MAX gene-associated protein isoform X9

    Conserved Domains (3) summary
    cd00182
    Location:74264
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
    pfam00010
    Location:22662316
    HLH; Helix-loop-helix DNA-binding domain
    pfam16059
    Location:10411087
    DUF4801; Domain of unknown function (DUF4801)
  25. XM_047432287.1XP_047288243.1  MAX gene-associated protein isoform X10

  26. XM_005254249.4XP_005254306.1  MAX gene-associated protein isoform X3

    Conserved Domains (3) summary
    cd00182
    Location:74264
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
    pfam00010
    Location:24262476
    HLH; Helix-loop-helix DNA-binding domain
    pfam16059
    Location:10411087
    DUF4801; Domain of unknown function (DUF4801)
  27. XM_047432290.1XP_047288246.1  MAX gene-associated protein isoform X11

  28. XM_011521397.4XP_011519699.1  MAX gene-associated protein isoform X5

    Conserved Domains (3) summary
    cd00182
    Location:74264
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
    pfam00010
    Location:23652415
    HLH; Helix-loop-helix DNA-binding domain
    pfam16059
    Location:10411087
    DUF4801; Domain of unknown function (DUF4801)
  29. XM_011521398.4XP_011519700.1  MAX gene-associated protein isoform X6

    Conserved Domains (3) summary
    cd00182
    Location:74264
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
    pfam00010
    Location:23642414
    HLH; Helix-loop-helix DNA-binding domain
    pfam16059
    Location:10411087
    DUF4801; Domain of unknown function (DUF4801)
  30. XM_047432292.1XP_047288248.1  MAX gene-associated protein isoform X13

  31. XM_047432293.1XP_047288249.1  MAX gene-associated protein isoform X14

  32. XM_005254252.4XP_005254309.1  MAX gene-associated protein isoform X7

    Conserved Domains (3) summary
    cd00182
    Location:74264
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
    pfam00010
    Location:23162366
    HLH; Helix-loop-helix DNA-binding domain
    pfam16059
    Location:10411087
    DUF4801; Domain of unknown function (DUF4801)
  33. XM_047432283.1XP_047288239.1  MAX gene-associated protein isoform X8

  34. XM_047432297.1XP_047288253.1  MAX gene-associated protein isoform X15

  35. XM_006720443.5XP_006720506.1  MAX gene-associated protein isoform X1

    See identical proteins and their annotated locations for XP_006720506.1

    Conserved Domains (3) summary
    cd00182
    Location:74264
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
    pfam00010
    Location:24752525
    HLH; Helix-loop-helix DNA-binding domain
    pfam16059
    Location:10411087
    DUF4801; Domain of unknown function (DUF4801)
  36. XM_047432278.1XP_047288234.1  MAX gene-associated protein isoform X2

  37. XM_047432289.1XP_047288245.1  MAX gene-associated protein isoform X10

  38. XM_047432282.1XP_047288238.1  MAX gene-associated protein isoform X6

  39. XM_047432296.1XP_047288252.1  MAX gene-associated protein isoform X14

  40. XM_047432285.1XP_047288241.1  MAX gene-associated protein isoform X8

  41. XM_047432310.1XP_047288266.1  MAX gene-associated protein isoform X29

  42. XM_047432312.1XP_047288268.1  MAX gene-associated protein isoform X30

  43. XM_047432309.1XP_047288265.1  MAX gene-associated protein isoform X28

  44. XM_047432311.1XP_047288267.1  MAX gene-associated protein isoform X30

  45. XM_047432313.1XP_047288269.1  MAX gene-associated protein isoform X31

  46. XM_005254254.5XP_005254311.1  MAX gene-associated protein isoform X26

    Conserved Domains (1) summary
    pfam00010
    Location:9871037
    HLH; Helix-loop-helix DNA-binding domain
  47. XM_011521399.4XP_011519701.1  MAX gene-associated protein isoform X27

    See identical proteins and their annotated locations for XP_011519701.1

    Conserved Domains (1) summary
    pfam00010
    Location:924974
    HLH; Helix-loop-helix DNA-binding domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    39427379..39575822
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)