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FLT4 fms related receptor tyrosine kinase 4 [ Homo sapiens (human) ]

Gene ID: 2324, updated on 21-Jun-2020

Summary

Official Symbol
FLT4provided by HGNC
Official Full Name
fms related receptor tyrosine kinase 4provided by HGNC
Primary source
HGNC:HGNC:3767
See related
Ensembl:ENSG00000037280 MIM:136352
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PCL; CHTD7; FLT-4; FLT41; LMPH1A; LMPHM1; VEGFR3; VEGFR-3
Summary
This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA. [provided by RefSeq, Jul 2008]
Expression
Broad expression in spleen (RPKM 7.7), lung (RPKM 6.7) and 21 other tissues See more
Orthologs

Genomic context

See FLT4 in Genome Data Viewer
Location:
5q35.3
Exon count:
35
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (180601506..180650298, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (180028506..180076624, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene CCR4-NOT transcription complex subunit 6 Neighboring gene proteolipid protein 2 (colonic epithelium-enriched) pseudogene Neighboring gene secretoglobin family 3A member 1 Neighboring gene coiled-coil domain containing 86 pseudogene Neighboring gene long intergenic non-protein coding RNA 2222

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
VEGF-C-activated receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
growth factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane receptor protein tyrosine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
vascular endothelial growth factor-activated receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
vascular endothelial growth factor-activated receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
blood vessel morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to vascular endothelial growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to vascular endothelial growth factor stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
hematopoietic progenitor cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lung alveolus development IEA
Inferred from Electronic Annotation
more info
 
lymph vessel development ISS
Inferred from Sequence or Structural Similarity
more info
 
lymphangiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
lymphangiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of protein kinase C signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of vascular endothelial growth factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of blood vessel remodeling ISS
Inferred from Sequence or Structural Similarity
more info
 
respiratory system process IEA
Inferred from Electronic Annotation
more info
 
sprouting angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vascular endothelial growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
vascular endothelial growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
vascular endothelial growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
vascular endothelial growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
vascular endothelial growth factor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
vasculature development ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
vascular endothelial growth factor receptor 3
Names
Feline McDonough Sarcoma (FMS)-like tyrosine kinase 4
VEGF receptor-3
fms related tyrosine kinase 4
fms-like tyrosine kinase 4
primary congenital lymphedema
tyrosine-protein kinase receptor FLT4
NP_001341918.1
NP_002011.2
NP_891555.2
XP_011532780.1
XP_011532786.1
XP_016864752.1
XP_016864753.1
XP_016864754.1
XP_016864755.1
XP_016864756.1
XP_016864757.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011536.1 RefSeqGene

    Range
    5025..53119
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001354989.2NP_001341918.1  vascular endothelial growth factor receptor 3 isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 3' terminal exon compared to variant 1. This results in an isoform (3) with a shorter C-terminus compared to isoform 1.
    Source sequence(s)
    AC122714
    Consensus CDS
    CCDS87360.1
    Related
    ENSP00000426057.1, ENST00000502649.5
    Conserved Domains (6) summary
    cd05862
    Location:245329
    Ig_VEGFR; Immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor(R)
    cd05863
    Location:352418
    Ig_VEGFR-3; Immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 3 (VEGFR-3)
    smart00408
    Location:693755
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:564657
    IG_like; Immunoglobulin like
    cd05102
    Location:8371176
    PTKc_VEGFR3; Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 3
    pfam13895
    Location:137224
    Ig_2; Immunoglobulin domain
  2. NM_002020.5NP_002011.2  vascular endothelial growth factor receptor 3 isoform 2 precursor

    See identical proteins and their annotated locations for NP_002011.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 3' terminal exon compared to variant 1. This results in an isoform (2) with a shorter C-terminus compared to isoform 1.
    Source sequence(s)
    AC122714, AY233382, DB455035, X68203
    Consensus CDS
    CCDS43412.1
    UniProtKB/Swiss-Prot
    P35916
    Related
    ENSP00000377016.3, ENST00000393347.7
    Conserved Domains (10) summary
    cd05862
    Location:245329
    Ig1_VEGFR; First immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor(R)
    cd05863
    Location:352418
    Ig2_VEGFR-3; Second immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 3 (VEGFR-3)
    smart00408
    Location:693755
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:564657
    IG; Immunoglobulin
    smart00410
    Location:238327
    IG_like; Immunoglobulin like
    pfam07679
    Location:678765
    I-set; Immunoglobulin I-set domain
    cd05102
    Location:8371176
    PTKc_VEGFR3; Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 3
    pfam07714
    Location:8451169
    Pkinase_Tyr; Protein tyrosine kinase
    pfam13895
    Location:138224
    Ig_2; Immunoglobulin domain
    cl11960
    Location:570658
    Ig; Immunoglobulin domain
  3. NM_182925.5NP_891555.2  vascular endothelial growth factor receptor 3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_891555.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC122714, AY233383, DB455035, X68203
    Consensus CDS
    CCDS4457.1
    UniProtKB/Swiss-Prot
    P35916
    Related
    ENSP00000261937.6, ENST00000261937.11
    Conserved Domains (10) summary
    cd05862
    Location:245329
    Ig1_VEGFR; First immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor(R)
    cd05863
    Location:352418
    Ig2_VEGFR-3; Second immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 3 (VEGFR-3)
    smart00408
    Location:693755
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:564657
    IG; Immunoglobulin
    smart00410
    Location:238327
    IG_like; Immunoglobulin like
    pfam07679
    Location:678765
    I-set; Immunoglobulin I-set domain
    cd05102
    Location:8371176
    PTKc_VEGFR3; Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 3
    pfam07714
    Location:8451169
    Pkinase_Tyr; Protein tyrosine kinase
    pfam13895
    Location:138224
    Ig_2; Immunoglobulin domain
    cl11960
    Location:570658
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    180601506..180650298 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009268.1XP_016864757.1  vascular endothelial growth factor receptor 3 isoform X5

  2. XM_017009263.1XP_016864752.1  vascular endothelial growth factor receptor 3 isoform X2

  3. XM_011534478.3XP_011532780.1  vascular endothelial growth factor receptor 3 isoform X1

    Conserved Domains (10) summary
    cd05862
    Location:322406
    Ig1_VEGFR; First immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor(R)
    cd05863
    Location:429495
    Ig2_VEGFR-3; Second immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 3 (VEGFR-3)
    smart00408
    Location:770832
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:641734
    IG; Immunoglobulin
    smart00410
    Location:315404
    IG_like; Immunoglobulin like
    pfam07679
    Location:755842
    I-set; Immunoglobulin I-set domain
    cd05102
    Location:9141253
    PTKc_VEGFR3; Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 3
    pfam07714
    Location:9221246
    Pkinase_Tyr; Protein tyrosine kinase
    pfam13895
    Location:215301
    Ig_2; Immunoglobulin domain
    cl11960
    Location:647735
    Ig; Immunoglobulin domain
  4. XM_011534484.2XP_011532786.1  vascular endothelial growth factor receptor 3 isoform X6

    Conserved Domains (10) summary
    cd05862
    Location:92176
    Ig1_VEGFR; First immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor(R)
    cd05863
    Location:199265
    Ig2_VEGFR-3; Second immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 3 (VEGFR-3)
    smart00408
    Location:540602
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:411504
    IG; Immunoglobulin
    smart00410
    Location:85174
    IG_like; Immunoglobulin like
    pfam07679
    Location:525612
    I-set; Immunoglobulin I-set domain
    cd05102
    Location:6841023
    PTKc_VEGFR3; Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 3
    pfam07714
    Location:6921016
    Pkinase_Tyr; Protein tyrosine kinase
    pfam13895
    Location:171
    Ig_2; Immunoglobulin domain
    cl11960
    Location:417505
    Ig; Immunoglobulin domain
  5. XM_017009266.1XP_016864755.1  vascular endothelial growth factor receptor 3 isoform X3

  6. XM_017009264.2XP_016864753.1  vascular endothelial growth factor receptor 3 isoform X2

  7. XM_017009265.1XP_016864754.1  vascular endothelial growth factor receptor 3 isoform X2

  8. XM_017009267.2XP_016864756.1  vascular endothelial growth factor receptor 3 isoform X4

RNA

  1. XR_001742050.2 RNA Sequence

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