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DNAJC9 DnaJ heat shock protein family (Hsp40) member C9 [ Homo sapiens (human) ]

Gene ID: 23234, updated on 3-May-2025
Official Symbol
DNAJC9provided by HGNC
Official Full Name
DnaJ heat shock protein family (Hsp40) member C9provided by HGNC
Primary source
HGNC:HGNC:19123
See related
Ensembl:ENSG00000213551 MIM:611206; AllianceGenome:HGNC:19123
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JDD1; SB73; HDJC9
Summary
Enables heat shock protein binding activity; histone binding activity; and protein-folding chaperone binding activity. Involved in nucleosome assembly and positive regulation of ATP-dependent activity. Located in several cellular components, including cytosol; extracellular space; and nucleoplasm. Part of protein folding chaperone complex. [provided by Alliance of Genome Resources, May 2025]
Expression
Ubiquitous expression in bone marrow (RPKM 34.5), lymph node (RPKM 15.2) and 24 other tissues See more
Orthologs
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See DNAJC9 in Genome Data Viewer
Location:
10q22.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (73232272..73247255, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (74100932..74118636, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (75001712..75007013, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 149 member B1 Neighboring gene uncharacterized LOC105378358 Neighboring gene NANOG hESC enhancer GRCh37_chr10:74965967-74966502 Neighboring gene eukaryotic translation initiation factor 4A2 pseudogene 2 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:75006455-75007654 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:75012121-75012688 Neighboring gene DNAJC9 and MRPS16 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:75015484-75015659 Neighboring gene mitochondrial ribosomal protein S16 Neighboring gene cilia and flagella associated protein 70 Neighboring gene RNA, U6 small nuclear 833, pseudogene

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. JDD1, a novel member of the DnaJ family, is expressed in the germinal zone of the rat brain. Takamura Y, et al. Biochem Biophys Res Commun, 2001 Jul 13. PMID 11444854
  2. Differential gene expression identified in Uigur women cervical squamous cell carcinoma by suppression subtractive hybridization. Pan Z, et al. Neoplasma, 2010. PMID 20099975
  3. ANXA7, PPP3CB, DNAJC9, and ZMYND17 genes at chromosome 10q22 associated with the subgroup of schizophrenia with deficits in attention and executive function. Liu CM, et al. Biol Psychiatry, 2011 Jul 1. PMID 21531385
  4. HDJC9, a novel human type C DnaJ/HSP40 member interacts with and cochaperones HSP70 through the J domain. Han C, et al. Biochem Biophys Res Commun, 2007 Feb 9. PMID 17182002
  5. Systematic Proteomic Identification of the Heat Shock Proteins (Hsp) that Interact with Estrogen Receptor Alpha (ERα) and Biochemical Characterization of the ERα-Hsp70 Interaction. Dhamad AE, et al. PLoS One, 2016. PMID 27483141, Free PMC Article

See all (125) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DNAJC9 integrates heat shock molecular chaperones into the histone chaperone network.
    Title: DNAJC9 integrates heat shock molecular chaperones into the histone chaperone network.
  2. ANXA7, PPP3CB, DNAJC9, and ZMYND17 genes are potential candidate genes for schizophrenia, especially in patients with deficits in sustained attention and executive function.
    Title: ANXA7, PPP3CB, DNAJC9, and ZMYND17 genes at chromosome 10q22 associated with the subgroup of schizophrenia with deficits in attention and executive function.
  3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  4. Up-regulation of DNAJC9 is associated with cervical squamous cell carcinoma.
    Title: Differential gene expression identified in Uigur women cervical squamous cell carcinoma by suppression subtractive hybridization.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA0974

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables heat shock protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heat shock protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-folding chaperone binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in nucleosome assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of ATP-dependent activity IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of protein folding chaperone complex IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
dnaJ homolog subfamily C member 9
Names
DnaJ (Hsp40) homolog, subfamily C, member 9
DnaJ protein SB73

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015190.5 → NP_056005.1  dnaJ homolog subfamily C member 9

    See identical proteins and their annotated locations for NP_056005.1

    Status: VALIDATED

    Source sequence(s)
    BC136507, BQ002383, BQ954888, BX646217, DA819115
    Consensus CDS
    CCDS7322.1
    UniProtKB/Swiss-Prot
    B2RMW6, Q8WXX5
    UniProtKB/TrEMBL
    Q2VIL4
    Related
    ENSP00000362041.4, ENST00000372950.6
    Conserved Domains (1) summary
    pfam00226
    Location:15 → 79
    DnaJ; DnaJ domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    73232272..73247255 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047424909.1 → XP_047280865.1  dnaJ homolog subfamily C member 9 isoform X1

    UniProtKB/TrEMBL
    Q2VIL4

  2. XM_047424908.1 → XP_047280864.1  dnaJ homolog subfamily C member 9 isoform X1

    UniProtKB/TrEMBL
    Q2VIL4

RNA

  1. XR_007061950.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    74100932..74118636 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054365348.1 → XP_054221323.1  dnaJ homolog subfamily C member 9 isoform X1

    UniProtKB/TrEMBL
    Q2VIL4

  2. XM_054365347.1 → XP_054221322.1  dnaJ homolog subfamily C member 9 isoform X1

    UniProtKB/TrEMBL
    Q2VIL4

RNA

  1. XR_008488186.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WXX5.1 GenPept UniProtKB/Swiss-Prot:Q8WXX5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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