DNAJC9 DnaJ heat shock protein family (Hsp40) member C9 [Homo sapiens (human)] - Gene

Summary

Official Symbol: DNAJC9provided by HGNC
Official Full Name: DnaJ heat shock protein family (Hsp40) member C9provided by HGNC
Primary source: HGNC:HGNC:19123
See related: Ensembl:ENSG00000213551 MIM:611206; AllianceGenome:HGNC:19123
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: JDD1; SB73; HDJC9
Summary: Enables chaperone binding activity; heat shock protein binding activity; and histone binding activity. Involved in nucleosome assembly and positive regulation of ATPase activity. Located in several cellular components, including cytosol; extracellular space; and nucleoplasm. Part of chaperone complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in bone marrow (RPKM 34.5), lymph node (RPKM 15.2) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10q22.2

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
110	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (73232272..73247255, complement)
110	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (74113334..74118636, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (75001712..75007013, complement)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DNAJC9 integrates heat shock molecular chaperones into the histone chaperone network.
Title: DNAJC9 integrates heat shock molecular chaperones into the histone chaperone network.
ANXA7, PPP3CB, DNAJC9, and ZMYND17 genes are potential candidate genes for schizophrenia, especially in patients with deficits in sustained attention and executive function.
Title: ANXA7, PPP3CB, DNAJC9, and ZMYND17 genes at chromosome 10q22 associated with the subgroup of schizophrenia with deficits in attention and executive function.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Up-regulation of DNAJC9 is associated with cervical squamous cell carcinoma.
Title: Differential gene expression identified in Uigur women cervical squamous cell carcinoma by suppression subtractive hybridization.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH69462 (e-PCR)
- UniSTS:87412

SHGC-35170 (e-PCR)
- UniSTS:58264

NoName (e-PCR)
- UniSTS:486564

STS-H83690 (e-PCR)
- UniSTS:5105

NoName (e-PCR)
- UniSTS:494845

Homology

Homologs of the DNAJC9 gene: The DNAJC9 gene is conserved in Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.pombe, M.oryzae, A.thaliana, rice, and frog.
Orthologs from Annotation Pipeline: 468 organisms have orthologs with human gene DNAJC9
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables chaperone binding	IDA Inferred from Direct Assay more info	PubMed
enables heat shock protein binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables heat shock protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables histone binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in nucleosome assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ATP-dependent activity	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of chaperone complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: dnaJ homolog subfamily C member 9

Names: DnaJ (Hsp40) homolog, subfamily C, member 9; DnaJ protein SB73

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.