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NUP210 nucleoporin 210 [ Homo sapiens (human) ]

Gene ID: 23225, updated on 21-Mar-2023

Summary

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Official Symbol
NUP210provided by HGNC
Official Full Name
nucleoporin 210provided by HGNC
Primary source
HGNC:HGNC:30052
See related
Ensembl:ENSG00000132182 MIM:607703; AllianceGenome:HGNC:30052
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GP210; POM210
Summary
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a membrane-spanning glycoprotein that is a major component of the nuclear pore complex. Multiple pseudogenes related to this gene are located on chromosome 3. [provided by RefSeq, Jul 2013]
Expression
Broad expression in lymph node (RPKM 17.2), bone marrow (RPKM 15.9) and 22 other tissues See more
Orthologs
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Genomic context

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See NUP210 in Genome Data Viewer
Location:
3p25.1
Exon count:
46
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (13316235..13420322, complement)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (13316581..13420679, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (13357735..13461822, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene IQ motif and Sec7 domain ArfGEF 1 Neighboring gene uncharacterized LOC124906214 Neighboring gene ribosomal protein L39 pseudogene 17 Neighboring gene NUP210-HDAC11 intergenic CAGE-defined high expression enhancer Neighboring gene PRR3 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Bioinformatics analysis of the expression and clinical significance of the NUP210 Gene in acute myeloid leukaemia. Li M, et al. Hematology, 2022 Dec. PMID 35413221
  2. Discovery of a Novel Aminocyclopropenone Compound That Inhibits BRD4-Driven Nucleoporin NUP210 Expression and Attenuates Colorectal Cancer Growth. Kondo H, et al. Cells, 2022 Jan 18. PMID 35159127, Free PMC Article
  3. Early Prognostic Utility of Gp210 Antibody-Positive Rate in Primary Biliary Cholangitis: A Meta-Analysis. Huang C, et al. Dis Markers, 2019. PMID 31737133, Free PMC Article
  4. Functional polymorphism within NUP210 encoding for nucleoporin GP210 is associated with the risk of endometriosis. Cipollini M, et al. Fertil Steril, 2019 Aug. PMID 31256999
  5. Increased expression of nuclear envelope gp210 antigen in small bile ducts in primary biliary cirrhosis. Nakamura M, et al. J Autoimmun, 2006 Mar. PMID 16337775

See all (119) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Bioinformatics analysis of the expression and clinical significance of the NUP210 Gene in acute myeloid leukaemia.
    Title: Bioinformatics analysis of the expression and clinical significance of the NUP210 Gene in acute myeloid leukaemia.
  2. Discovery of a Novel Aminocyclopropenone Compound That Inhibits BRD4-Driven Nucleoporin NUP210 Expression and Attenuates Colorectal Cancer Growth.
    Title: Discovery of a Novel Aminocyclopropenone Compound That Inhibits BRD4-Driven Nucleoporin NUP210 Expression and Attenuates Colorectal Cancer Growth.
  3. Nuclear pore protein NUP210 depletion suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response.
    Title: Nuclear pore protein NUP210 depletion suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response.
  4. Nucleoporin 210 Serves a Key Scaffold for SMARCB1 in Liver Cancer.
    Title: Nucleoporin 210 Serves a Key Scaffold for SMARCB1 in Liver Cancer.
  5. NUP205 and NUP210 mutations are associated with defects in cardiac patterning.
    Title: Bi-Allelic Mutations in NUP205 and NUP210 Are Associated With Abnormal Cardiac Left-Right Patterning.
  6. miR-22-regulated expression of NUP210 could alter Fas expression and, in turn, elicit cell cycle arrest and proliferation.
    Title: NUP210 and MicroRNA-22 Modulate Fas to Elicit HeLa Cell Cycle Arrest.
  7. Primary biliary cholangitis-specific Gp120 antibodies are optimal predictors of primary biliary cholangitis prognosis at the time of diagnosis.
    Title: Early Prognostic Utility of Gp210 Antibody-Positive Rate in Primary Biliary Cholangitis: A Meta-Analysis.
  8. Nucleoporin GP210 is involved in endometriosis. Rs354476 polymorphism affects the regulation of NUP210 gene expression by altering the binding with hsa-miR-125b-5p, a microRNA already known as playing an important role for endometriosis. This provides the rationale for the observed increased risk of endometriosis in carriers of the variant allele.
    Title: Functional polymorphism within NUP210 encoding for nucleoporin GP210 is associated with the risk of endometriosis.
  9. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  10. Observational study of gene-disease association. (HuGE Navigator)
    Title: Association of genetic variants with hemorrhagic stroke in Japanese individuals.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with NUP210 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ22389, KIAA0906

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleocytoplasmic transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane HDA PubMed 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear envelope TAS
Traceable Author Statement
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
part_of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
part_of nuclear pore NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
nuclear pore membrane glycoprotein 210
Names
nuclear envelope pore membrane protein POM 210
nuclear pore protein gp210
nucleoporin 210kDa
nucleoporin Nup210
pore membrane protein of 210 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024923.4 → NP_079199.2  nuclear pore membrane glycoprotein 210 precursor

    See identical proteins and their annotated locations for NP_079199.2

    Status: REVIEWED

    Source sequence(s)
    AB020713, AC027124, AK074101, BC067089, BM508095, HY177936
    Consensus CDS
    CCDS33704.1
    UniProtKB/Swiss-Prot
    Q8TEM1, Q9UFP3
    Related
    ENSP00000254508.5, ENST00000254508.7
    Conserved Domains (1) summary
    pfam02368
    Location:1079 → 1152
    Big_2; Bacterial Ig-like domain (group 2)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    13316235..13420322 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047447797.1 → XP_047303753.1  nuclear pore membrane glycoprotein 210 isoform X5

  2. XM_047447795.1 → XP_047303751.1  nuclear pore membrane glycoprotein 210 isoform X3

  3. XM_047447796.1 → XP_047303752.1  nuclear pore membrane glycoprotein 210 isoform X4

  4. XM_011533538.3 → XP_011531840.1  nuclear pore membrane glycoprotein 210 isoform X2

  5. XM_005264994.4 → XP_005265051.1  nuclear pore membrane glycoprotein 210 isoform X1

  6. XM_047447798.1 → XP_047303754.1  nuclear pore membrane glycoprotein 210 isoform X6

RNA

  1. XR_007095651.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    13316581..13420679 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054345851.1 → XP_054201826.1  nuclear pore membrane glycoprotein 210 isoform X5

  2. XM_054345849.1 → XP_054201824.1  nuclear pore membrane glycoprotein 210 isoform X3

  3. XM_054345850.1 → XP_054201825.1  nuclear pore membrane glycoprotein 210 isoform X4

  4. XM_054345848.1 → XP_054201823.1  nuclear pore membrane glycoprotein 210 isoform X1

  5. XM_054345852.1 → XP_054201827.1  nuclear pore membrane glycoprotein 210 isoform X6

RNA

  1. XR_008486679.1 RNA Sequence

  2. XR_008486680.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8TEM1.3 GenPept UniProtKB/Swiss-Prot:Q8TEM1

Gene LinkOut

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