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NUP210 nucleoporin 210 [ Homo sapiens (human) ]

Gene ID: 23225, updated on 7-Apr-2024

Summary

Official Symbol
NUP210provided by HGNC
Official Full Name
nucleoporin 210provided by HGNC
Primary source
HGNC:HGNC:30052
See related
Ensembl:ENSG00000132182 MIM:607703; AllianceGenome:HGNC:30052
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GP210; POM210
Summary
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a membrane-spanning glycoprotein that is a major component of the nuclear pore complex. Multiple pseudogenes related to this gene are located on chromosome 3. [provided by RefSeq, Jul 2013]
Expression
Broad expression in lymph node (RPKM 17.2), bone marrow (RPKM 15.9) and 22 other tissues See more
Orthologs
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Genomic context

See NUP210 in Genome Data Viewer
Location:
3p25.1
Exon count:
46
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (13316235..13420322, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (13316581..13420679, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (13357735..13461822, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene IQ motif and Sec7 domain ArfGEF 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19466 Neighboring gene uncharacterized LOC124906214 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19467 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13055383-13055884 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13055885-13056384 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13056642-13057410 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13057411-13058178 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19470 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13058755-13059554 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13059555-13060352 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13060353-13061150 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19473 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19472 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19471 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19474 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14080 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13068313-13068814 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13068815-13069314 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13072358-13073358 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13073359-13074357 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13076449-13076949 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19475 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19476 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13083243-13083838 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19477 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13088478-13088996 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19478 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13098528-13099036 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13099037-13099544 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19479 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19480 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14081 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14082 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13121681-13122182 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13122183-13122682 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14083 Neighboring gene ribosomal protein L39 pseudogene 17 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19481 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19483 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19482 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13129843-13130342 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13144801-13145570 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19484 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13202841-13203366 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13212946-13213470 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13213471-13213994 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13215820-13216320 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13234555-13235161 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13235162-13235768 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13239281-13239901 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13240462-13241008 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13250445-13250980 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13250981-13251518 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13261232-13261755 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13261756-13262278 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13262279-13262801 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13273335-13273836 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13279021-13279625 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13279626-13280229 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:13283606-13283809 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13295276-13296085 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13296086-13296894 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:13298218-13298718 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:13298719-13299219 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13301694-13302474 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13318107-13318607 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:13318634-13318918 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13319003-13319504 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19485 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:13363927-13364126 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13368867-13369366 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13368365-13368866 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:13372259-13372426 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19486 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19487 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13387355-13388236 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13388237-13389120 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13389121-13390003 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13390887-13391769 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:13415591-13416092 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:13430034-13430534 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13432338-13432896 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13440837-13441368 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13441369-13441898 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:13442941-13443441 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19488 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19489 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19490 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14084 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14085 Neighboring gene NUP210-HDAC11 intergenic CAGE-defined high expression enhancer Neighboring gene Sharpr-MPRA regulatory region 3172 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19491 Neighboring gene HDAC11 antisense RNA 1 Neighboring gene PRR3 pseudogene 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ22389, KIAA0906

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
 
involved_in nucleocytoplasmic transport NAS
Non-traceable Author Statement
more info
PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane HDA PubMed 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear envelope TAS
Traceable Author Statement
more info
 
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
 
part_of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of nuclear pore NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
nuclear pore membrane glycoprotein 210
Names
nuclear envelope pore membrane protein POM 210
nuclear pore protein gp210
nucleoporin 210kDa
nucleoporin Nup210
pore membrane protein of 210 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024923.4NP_079199.2  nuclear pore membrane glycoprotein 210 precursor

    See identical proteins and their annotated locations for NP_079199.2

    Status: REVIEWED

    Source sequence(s)
    AB020713, AC027124, AK074101, BC067089, BM508095, HY177936
    Consensus CDS
    CCDS33704.1
    UniProtKB/Swiss-Prot
    A6NN56, O94980, Q6NXG6, Q8NBJ1, Q8TEM1, Q9H6C8, Q9UFP3
    Related
    ENSP00000254508.5, ENST00000254508.7
    Conserved Domains (1) summary
    pfam02368
    Location:10791152
    Big_2; Bacterial Ig-like domain (group 2)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    13316235..13420322 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047447797.1XP_047303753.1  nuclear pore membrane glycoprotein 210 isoform X5

  2. XM_047447795.1XP_047303751.1  nuclear pore membrane glycoprotein 210 isoform X3

  3. XM_047447796.1XP_047303752.1  nuclear pore membrane glycoprotein 210 isoform X4

  4. XM_011533538.3XP_011531840.1  nuclear pore membrane glycoprotein 210 isoform X2

  5. XM_005264994.4XP_005265051.1  nuclear pore membrane glycoprotein 210 isoform X1

  6. XM_047447798.1XP_047303754.1  nuclear pore membrane glycoprotein 210 isoform X6

RNA

  1. XR_007095651.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    13316581..13420679 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054345851.1XP_054201826.1  nuclear pore membrane glycoprotein 210 isoform X5

  2. XM_054345849.1XP_054201824.1  nuclear pore membrane glycoprotein 210 isoform X3

  3. XM_054345850.1XP_054201825.1  nuclear pore membrane glycoprotein 210 isoform X4

  4. XM_054345848.1XP_054201823.1  nuclear pore membrane glycoprotein 210 isoform X1

  5. XM_054345852.1XP_054201827.1  nuclear pore membrane glycoprotein 210 isoform X6

RNA

  1. XR_008486679.1 RNA Sequence

  2. XR_008486680.1 RNA Sequence