Format

Send to:

Choose Destination

NUP210 nucleoporin 210 [ Homo sapiens (human) ]

Gene ID: 23225, updated on 7-Jun-2020

Summary

Official Symbol
NUP210provided by HGNC
Official Full Name
nucleoporin 210provided by HGNC
Primary source
HGNC:HGNC:30052
See related
Ensembl:ENSG00000132182 MIM:607703
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GP210; POM210
Summary
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a membrane-spanning glycoprotein that is a major component of the nuclear pore complex. Multiple pseudogenes related to this gene are located on chromosome 3. [provided by RefSeq, Jul 2013]
Expression
Broad expression in lymph node (RPKM 17.2), bone marrow (RPKM 15.9) and 22 other tissues See more
Orthologs

Genomic context

See NUP210 in Genome Data Viewer
Location:
3p25.1
Exon count:
42
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (13316235..13420322, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (13357730..13461819, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376956 Neighboring gene long intergenic non-protein coding RNA 2022 Neighboring gene IQ motif and Sec7 domain ArfGEF 1 Neighboring gene ribosomal protein L39 pseudogene 17 Neighboring gene NUP210-HDAC11 intergenic CAGE-defined high expression enhancer Neighboring gene proline-rich protein 3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22389, KIAA0906

Gene Ontology Provided by GOA

Process Evidence Code Pubs
intracellular transport of virus TAS
Traceable Author Statement
more info
 
mRNA export from nucleus TAS
Traceable Author Statement
more info
 
protein sumoylation TAS
Traceable Author Statement
more info
 
protein-containing complex assembly IEA
Inferred from Electronic Annotation
more info
 
regulation of cellular response to heat TAS
Traceable Author Statement
more info
 
regulation of gene silencing by miRNA TAS
Traceable Author Statement
more info
 
regulation of glycolytic process TAS
Traceable Author Statement
more info
 
tRNA export from nucleus TAS
Traceable Author Statement
more info
 
viral process TAS
Traceable Author Statement
more info
 
viral transcription TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
host cell IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
nuclear envelope TAS
Traceable Author Statement
more info
 
nuclear membrane IEA
Inferred from Electronic Annotation
more info
 
nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
nuclear pore membrane glycoprotein 210
Names
nuclear envelope pore membrane protein POM 210
nuclear pore protein gp210
nucleoporin 210kDa
nucleoporin Nup210
pore membrane protein of 210 kDa

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024923.4NP_079199.2  nuclear pore membrane glycoprotein 210 precursor

    See identical proteins and their annotated locations for NP_079199.2

    Status: REVIEWED

    Source sequence(s)
    AB020713, AC027124, AK074101, BC067089, BM508095, HY177936
    Consensus CDS
    CCDS33704.1
    UniProtKB/Swiss-Prot
    Q8TEM1
    Related
    ENSP00000254508.5, ENST00000254508.7
    Conserved Domains (1) summary
    pfam02368
    Location:10791152
    Big_2; Bacterial Ig-like domain (group 2)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    13316235..13420322 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453411.1XP_024309179.1  nuclear pore membrane glycoprotein 210 isoform X1

    Conserved Domains (1) summary
    pfam02368
    Location:10791152
    Big_2; Bacterial Ig-like domain (group 2)
  2. XM_024453416.1XP_024309184.1  nuclear pore membrane glycoprotein 210 isoform X8

    Conserved Domains (1) summary
    pfam02368
    Location:123196
    Big_2; Bacterial Ig-like domain (group 2)
  3. XM_024453413.1XP_024309181.1  nuclear pore membrane glycoprotein 210 isoform X3

    Conserved Domains (1) summary
    pfam02368
    Location:196269
    Big_2; Bacterial Ig-like domain (group 2)
  4. XM_024453412.1XP_024309180.1  nuclear pore membrane glycoprotein 210 isoform X2

    Conserved Domains (1) summary
    pfam02368
    Location:207280
    Big_2; Bacterial Ig-like domain (group 2)
  5. XM_024453414.1XP_024309182.1  nuclear pore membrane glycoprotein 210 isoform X4

    Conserved Domains (1) summary
    pfam02368
    Location:188261
    Big_2; Bacterial Ig-like domain (group 2)
  6. XM_024453415.1XP_024309183.1  nuclear pore membrane glycoprotein 210 isoform X5

    Conserved Domains (1) summary
    pfam02368
    Location:184257
    Big_2; Bacterial Ig-like domain (group 2)
  7. XM_017006021.1XP_016861510.1  nuclear pore membrane glycoprotein 210 isoform X9

  8. XM_011533538.2XP_011531840.1  nuclear pore membrane glycoprotein 210 isoform X7

  9. XM_005264994.3XP_005265051.1  nuclear pore membrane glycoprotein 210 isoform X6

    Related
    ENST00000420141.2
Support Center