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FBXO28 F-box protein 28 [ Homo sapiens (human) ]

Gene ID: 23219, updated on 10-Oct-2019

Summary

Official Symbol
FBXO28provided by HGNC
Official Full Name
F-box protein 28provided by HGNC
Primary source
HGNC:HGNC:29046
See related
Ensembl:ENSG00000143756 MIM:609100
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Fbx28; CENP-30
Summary
Members of the F-box protein family, such as FBXO28, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in skin (RPKM 11.4), esophagus (RPKM 8.4) and 25 other tissues See more
Orthologs

Genomic context

See FBXO28 in Genome Data Viewer
Location:
1q42.11
Exon count:
5
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (224114111..224162047)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (224301789..224349749)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373061 Neighboring gene uncharacterized LOC105373056 Neighboring gene RN7SK pseudogene 49 Neighboring gene Sharpr-MPRA regulatory region 12248 Neighboring gene zinc finger protein 706 pseudogene Neighboring gene delta 4-desaturase, sphingolipid 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10766, KIAA0483

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
condensed chromosome kinetochore IEA
Inferred from Electronic Annotation
more info
 
kinetochore IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
F-box only protein 28
Names
centromere protein 30

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136115.3NP_001129587.1  F-box only protein 28 isoform b

    See identical proteins and their annotated locations for NP_001129587.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AL390122
    Consensus CDS
    CCDS44320.1
    UniProtKB/Swiss-Prot
    Q9NVF7
    Related
    ENSP00000416888.2, ENST00000424254.6
    Conserved Domains (1) summary
    pfam00646
    Location:6794
    F-box; F-box domain
  2. NM_015176.4NP_055991.1  F-box only protein 28 isoform a

    See identical proteins and their annotated locations for NP_055991.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AL390122
    Consensus CDS
    CCDS1539.1
    UniProtKB/Swiss-Prot
    Q9NVF7
    UniProtKB/TrEMBL
    A0A024R3Q6
    Related
    ENSP00000355827.5, ENST00000366862.10
    Conserved Domains (1) summary
    pfam00646
    Location:67108
    F-box; F-box domain

RNA

  1. NR_049764.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL390122

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    224114111..224162047
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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