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RCOR1 REST corepressor 1 [ Homo sapiens (human) ]

Gene ID: 23186, updated on 5-Mar-2024

Summary

Official Symbol
RCOR1provided by HGNC
Official Full Name
REST corepressor 1provided by HGNC
Primary source
HGNC:HGNC:17441
See related
Ensembl:ENSG00000089902 MIM:607675; AllianceGenome:HGNC:17441
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RCOR; COREST
Summary
This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor). [provided by RefSeq, Aug 2011]
Expression
Ubiquitous expression in bone marrow (RPKM 19.5), esophagus (RPKM 14.2) and 25 other tissues See more
Orthologs
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Genomic context

See RCOR1 in Genome Data Viewer
Location:
14q32.31-q32.32
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (102592649..102730561)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (96828874..96966907)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (103058986..103196898)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6124 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6125 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103022683-103023183 Neighboring gene MPRA-validated peak2254 silencer Neighboring gene long intergenic non-protein coding RNA 2323 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9074 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:103036323-103036892 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:103039389-103040275 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:103040276-103041163 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:103045898-103046584 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:103046585-103047269 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:103050544-103051072 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9075 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:103057589-103058404 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6127 Neighboring gene RNA, 7SL, cytoplasmic 546, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9076 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:103119605-103120104 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:103129073-103129810 Neighboring gene ribosomal protein L23a pseudogene 11 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9077 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:103174038-103175237 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:103188411-103189610 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103204471-103204972 Neighboring gene uncharacterized LOC124903390 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:103213106-103213279 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103216089-103216923 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9078 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9079 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103224133-103224633 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9081 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103236826-103237330 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103237331-103237835 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9082 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6128 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6129 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6130 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6131 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:103249335-103249487 Neighboring gene small nucleolar RNA U13 Neighboring gene TNF receptor associated factor 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat LSD1/KDM1 and CoREST proteins are recruited to the HIV-1 LTR in response to HIV-1 Tat and formation of the LSD1/KDM1/CoREST complex functions as a co-activator of HIV-1 transcription PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA0071

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
 
enables enzyme binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in erythrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of megakaryocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of DNA repair complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of histone deacetylase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of transcription repressor complex IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015156.4NP_055971.2  REST corepressor 1

    See identical proteins and their annotated locations for NP_055971.2

    Status: REVIEWED

    Source sequence(s)
    AF070627, AI337324, AL136293, BC051003, D31888, DB455887
    Consensus CDS
    CCDS9974.2
    UniProtKB/Swiss-Prot
    J3KN32, Q15044, Q6P2I9, Q86VG5, Q9UKL0
    Related
    ENSP00000262241.5, ENST00000262241.7
    Conserved Domains (3) summary
    pfam00249
    Location:385428
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam01448
    Location:105158
    ELM2; ELM2 domain
    cl21498
    Location:194238
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    102592649..102730561
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047431148.1XP_047287104.1  REST corepressor 1 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    96828874..96966907
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054375665.1XP_054231640.1  REST corepressor 1 isoform X1