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RCOR1 REST corepressor 1 [ Homo sapiens (human) ]

Gene ID: 23186, updated on 3-May-2020

Summary

Official Symbol
RCOR1provided by HGNC
Official Full Name
REST corepressor 1provided by HGNC
Primary source
HGNC:HGNC:17441
See related
Ensembl:ENSG00000089902 MIM:607675
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RCOR; COREST
Summary
This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor). [provided by RefSeq, Aug 2011]
Expression
Ubiquitous expression in bone marrow (RPKM 19.5), esophagus (RPKM 14.2) and 25 other tissues See more
Orthologs

Genomic context

See RCOR1 in Genome Data Viewer
Location:
14q32.31-q32.32
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (102592593..102730572)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (103058996..103196913)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2323 Neighboring gene RNA, 7SL, cytoplasmic 546, pseudogene Neighboring gene ribosomal protein L23a pseudogene 11 Neighboring gene TNF receptor associated factor 3 Neighboring gene RNA, U6 small nuclear 1316, pseudogene Neighboring gene CDC42 binding protein kinase beta Neighboring gene amnion associated transmembrane protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat LSD1/KDM1 and CoREST proteins are recruited to the HIV-1 LTR in response to HIV-1 Tat and formation of the LSD1/KDM1/CoREST complex functions as a co-activator of HIV-1 transcription PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0071

Gene Ontology Provided by GOA

Process Evidence Code Pubs
blood coagulation TAS
Traceable Author Statement
more info
 
histone H4 deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
DNA repair complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 
transcriptional repressor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcriptional repressor complex IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015156.4NP_055971.2  REST corepressor 1

    See identical proteins and their annotated locations for NP_055971.2

    Status: REVIEWED

    Source sequence(s)
    AF070627, AI337324, AL136293, BC051003, D31888, DB455887
    Consensus CDS
    CCDS9974.2
    UniProtKB/Swiss-Prot
    Q9UKL0
    Related
    ENSP00000262241.5, ENST00000262241.7
    Conserved Domains (3) summary
    pfam00249
    Location:385428
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam01448
    Location:105158
    ELM2; ELM2 domain
    cl21498
    Location:194238
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    102592593..102730572
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_943406.3 RNA Sequence

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