Snx8 sorting nexin 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Snx8provided by MGI
Official Full Name: sorting nexin 8provided by MGI
Primary source: MGI:MGI:2443816
See related: Ensembl:ENSMUSG00000029560 AllianceGenome:MGI:2443816
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: B130023O14Rik
Summary: Predicted to enable identical protein binding activity and phosphatidylinositol binding activity. Predicted to be involved in early endosome to Golgi transport and intracellular protein transport. Predicted to act upstream of or within protein transport. Predicted to be located in early endosome membrane. Predicted to be part of retromer complex. Orthologous to human SNX8 (sorting nexin 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in kidney adult (RPKM 15.1), spleen adult (RPKM 10.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 78.95 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (140326048..140375063, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (140340293..140389308, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fatty Acid Synthase-Suppressor Screening Identifies Sorting Nexin 8 as a Therapeutic Target for NAFLD.
Title: Fatty Acid Synthase-Suppressor Screening Identifies Sorting Nexin 8 as a Therapeutic Target for NAFLD.
SNX8 modulates the innate immune response to RNA viruses by regulating the aggregation of VISA.
Title: SNX8 modulates the innate immune response to RNA viruses by regulating the aggregation of VISA.
SNX8 mediates IFNG-triggered non-canonical signaling pathway and host defense against Listeria monocytogenes.
Title: SNX8 mediates IFNγ-triggered noncanonical signaling pathway and host defense against Listeria monocytogenes.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in early endosome to Golgi transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in early endosome to Golgi transport	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in retrograde transport, endosome to Golgi	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in early endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome membrane	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of retromer complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sorting nexin-8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172277.3 → NP_758481.1 sorting nexin-8

See identical proteins and their annotated locations for NP_758481.1

Status: VALIDATED

Source sequence(s)

AC131670, AK148429

Consensus CDS

CCDS39356.1

UniProtKB/Swiss-Prot

Q8BLI6, Q8BUQ7, Q8CFD4

UniProtKB/TrEMBL

Q3U0I9

Related

ENSMUSP00000031539.8, ENSMUST00000031539.12

Conserved Domains (2) summary

cd06866
Location:70 → 173

PX_SNX8_Mvp1p_like; The phosphoinositide binding Phox Homology domain of Sorting Nexin 8 and yeast Mvp1p

cd07597
Location:190 → 434

BAR_SNX8; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

140326048..140375063 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030254436.2 → XP_030110296.1 sorting nexin-8 isoform X3

UniProtKB/TrEMBL

Q3U0I9

Conserved Domains (2) summary

cd06866
Location:70 → 173

PX_SNX8_Mvp1p_like; The phosphoinositide binding Phox Homology domain of Sorting Nexin 8 and yeast Mvp1p

cd07597
Location:176 → 407

BAR_SNX8; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 8
XM_036165098.1 → XP_036020991.1 sorting nexin-8 isoform X6

Conserved Domains (1) summary

cd07597
Location:1 → 242

BAR_SNX8; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 8
XM_006504673.4 → XP_006504736.1 sorting nexin-8 isoform X2

UniProtKB/TrEMBL

Q3U0I9

Conserved Domains (2) summary

cd06866
Location:71 → 174

PX_SNX8_Mvp1p_like; The phosphoinositide binding Phox Homology domain of Sorting Nexin 8 and yeast Mvp1p

cd07597
Location:177 → 408

BAR_SNX8; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 8
XM_006504672.2 → XP_006504735.1 sorting nexin-8 isoform X1

UniProtKB/TrEMBL

Q3U0I9

Related

ENSMUSP00000142556.2, ENSMUST00000196566.5

Conserved Domains (2) summary

cd06866
Location:71 → 174

PX_SNX8_Mvp1p_like; The phosphoinositide binding Phox Homology domain of Sorting Nexin 8 and yeast Mvp1p

cd07597
Location:191 → 435

BAR_SNX8; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 8
XM_030254437.2 → XP_030110297.1 sorting nexin-8 isoform X5

Conserved Domains (2) summary

cd06866
Location:70 → 173

PX_SNX8_Mvp1p_like; The phosphoinositide binding Phox Homology domain of Sorting Nexin 8 and yeast Mvp1p

cl12013
Location:190 → 300

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_006504674.5 → XP_006504737.1 sorting nexin-8 isoform X4

Conserved Domains (2) summary

cd06866
Location:71 → 174

PX_SNX8_Mvp1p_like; The phosphoinositide binding Phox Homology domain of Sorting Nexin 8 and yeast Mvp1p

cl12013
Location:191 → 301

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature