Format

Send to:

Choose Destination

LPIN1 lipin 1 [ Homo sapiens (human) ]

Gene ID: 23175, updated on 8-Jul-2018
Official Symbol
LPIN1provided by HGNC
Official Full Name
lipin 1provided by HGNC
Primary source
HGNC:HGNC:13345
See related
Ensembl:ENSG00000134324 MIM:605518; Vega:OTTHUMG00000119082
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAP1
Summary
This gene encodes a magnesium-ion-dependent phosphatidic acid phosphohydrolase enzyme that catalyzes the penultimate step in triglyceride synthesis including the dephosphorylation of phosphatidic acid to yield diacylglycerol. Expression of this gene is required for adipocyte differentiation and it also functions as a nuclear transcriptional coactivator with some peroxisome proliferator-activated receptors to modulate expression of other genes involved in lipid metabolism. Mutations in this gene are associated with metabolic syndrome, type 2 diabetes, acute recurrent rhabdomyolysis, and autosomal recessive acute recurrent myoglobinuria (ARARM). This gene is also a candidate for several human lipodystrophy syndromes. [provided by RefSeq, Mar 2017]
Expression
Broad expression in testis (RPKM 18.7), ovary (RPKM 8.2) and 24 other tissues See more
Orthologs
See LPIN1 in Genome Data Viewer
Location:
2p25.1
Exon count:
33
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (11677544..11827409)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (11817705..11967535)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene growth regulating estrogen receptor binding 1 Neighboring gene RNA, 7SL, cytoplasmic 674, pseudogene Neighboring gene uncharacterized LOC100506405 Neighboring gene uncharacterized LOC101929752 Neighboring gene cyclin dependent kinase 8 pseudogene 1 Neighboring gene neurotensin receptor 2 Neighboring gene uncharacterized LOC105373430 Neighboring gene microRNA 548s Neighboring gene microRNA 4262 Neighboring gene MIR3681 host gene Neighboring gene ST13, Hsp70 interacting protein pseudogene 1

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Adipogenesis, organism-specific biosystem (from WikiPathways)
    Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
  • Depolymerisation of the Nuclear Lamina, organism-specific biosystem (from REACTOME)
    Depolymerisation of the Nuclear Lamina, organism-specific biosystemThe nuclear envelope breakdown in mitotic prophase involves depolymerisation of lamin filaments, the main constituents of the nuclear lamina. The nuclear lamina is located at the nuclear face of the ...
  • Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
    Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemThe reactions involved in the metabolism of fatty acids and of the triacylglycerols and ketone bodies derived from them form a closely interrelated, coordinately regulated module that plays a central...
  • Glycerolipid metabolism, organism-specific biosystem (from KEGG)
    Glycerolipid metabolism, organism-specific biosystem
    Glycerolipid metabolism
  • Glycerolipid metabolism, conserved biosystem (from KEGG)
    Glycerolipid metabolism, conserved biosystem
    Glycerolipid metabolism
  • Glycerophospholipid Biosynthetic Pathway, organism-specific biosystem (from WikiPathways)
    Glycerophospholipid Biosynthetic Pathway, organism-specific biosystemGlycerophospholipids or phosphoglycerides, in which the hydrophobic regions are composed of two fatty acids joined to glycerol; and sphingolipids, in which a single fatty acid is joined to a fatty am...
  • Glycerophospholipid biosynthesis, organism-specific biosystem (from REACTOME)
    Glycerophospholipid biosynthesis, organism-specific biosystemGlycerophospholipids are important structural and functional components of biological membranes and constituents of serum lipoproteins and the pulmonary surfactant. In addition, glycerophospholipids...
  • Glycerophospholipid metabolism, organism-specific biosystem (from KEGG)
    Glycerophospholipid metabolism, organism-specific biosystem
    Glycerophospholipid metabolism
  • Glycerophospholipid metabolism, conserved biosystem (from KEGG)
    Glycerophospholipid metabolism, conserved biosystem
    Glycerophospholipid metabolism
  • M Phase, organism-specific biosystem (from REACTOME)
    M Phase, organism-specific biosystemMitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced. Mitosis involves prophase, prometaphase, metaphase, anaphase, and telophase. Fin...
  • Metabolic pathways, organism-specific biosystem (from KEGG)
    Metabolic pathways, organism-specific biosystem
    Metabolic pathways
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • Mitotic Prophase, organism-specific biosystem (from REACTOME)
    Mitotic Prophase, organism-specific biosystemDuring prophase, the chromatin in the nucleus condenses, and the nucleolus disappears. Centrioles begin moving to the opposite poles or sides of the cell. Some of the fibers that extend from the cen...
  • Nuclear Envelope Breakdown, organism-specific biosystem (from REACTOME)
    Nuclear Envelope Breakdown, organism-specific biosystemThe nuclear envelope breakdown (NEBD) happens in late prophase of mitosis and involves disassembly of the nuclear pore complex, depolymerization of the nuclear lamina, and clearance of nuclear envelo...
  • Phospholipid metabolism, organism-specific biosystem (from REACTOME)
    Phospholipid metabolism, organism-specific biosystemPhospholipids contain a polar head group and two long-chain fatty acyl moieties, one of which is generally unsaturated. The head group is a glycerol or serine phosphate attached to a polar group such...
  • Sterol Regulatory Element-Binding Proteins (SREBP) signalling, organism-specific biosystem (from WikiPathways)
    Sterol Regulatory Element-Binding Proteins (SREBP) signalling, organism-specific biosystemSterol regulatory element-binding proteins (SREBPs) are membrane-bound proteins that act as transcription factors. They regulate lipid, especially cholesterol, biosynthesis and uptake at a transcript...
  • Synthesis of PC, organism-specific biosystem (from REACTOME)
    Synthesis of PC, organism-specific biosystemDe novo (Kennedy pathway) synthesis of phosphatidylcholine (PC) involves phosphorylation of choline (Cho) to phosphocholine (PCho) followed by condensing with cytidine triphosphate (CTP) to form CDP-...
  • Synthesis of PE, organism-specific biosystem (from REACTOME)
    Synthesis of PE, organism-specific biosystemDe novo (Kennedy pathway) synthesis of phosphatidylethanolamine (PE) involves phosphorylation of ethanolamine (ETA) to phosphoethanolamine (PETA) followed by condensing with cytidine triphosphate (CT...
  • Transcription factor regulation in adipogenesis, organism-specific biosystem (from WikiPathways)
    Transcription factor regulation in adipogenesis, organism-specific biosystemThe transcription factors involved in adipogenesis are shown in the current pathway. Adipogensis is the biological proces of cell differentation in which preadipocytes are converted into adipocytes.
  • Triglyceride Biosynthesis, organism-specific biosystem (from REACTOME)
    Triglyceride Biosynthesis, organism-specific biosystemThe overall process of triglyceride (triacylglycerol) biosynthesis consists of four biochemical pathways: fatty acyl-CoA biosynthesis, conversion of fatty acyl-CoA to phosphatidic acid, conversion of...
  • mTOR signaling pathway, organism-specific biosystem (from KEGG)
    mTOR signaling pathway, organism-specific biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...
  • mTOR signaling pathway, conserved biosystem (from KEGG)
    mTOR signaling pathway, conserved biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA0188, DKFZp781P1796

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
phosphatidate phosphatase activity EXP
Inferred from Experiment
more info
PubMed 
phosphatidate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
animal organ regeneration IEA
Inferred from Electronic Annotation
more info
 
cellular response to insulin stimulus IEA
Inferred from Electronic Annotation
more info
 
dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
fatty acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fatty acid catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
mitotic nuclear envelope disassembly TAS
Traceable Author Statement
more info
 
phosphatidylcholine biosynthetic process TAS
Traceable Author Statement
more info
 
phosphatidylethanolamine biosynthetic process TAS
Traceable Author Statement
more info
 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
triglyceride biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
triglyceride biosynthetic process TAS
Traceable Author Statement
more info
 
triglyceride mobilization ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear envelope TAS
Traceable Author Statement
more info
 
nuclear membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Preferred Names
phosphatidate phosphatase LPIN1
NP_001248356.1
NP_001248357.1
NP_001336128.1
NP_001336129.1
NP_001336130.1
NP_001336131.1
NP_001336132.1
NP_001336133.1
NP_001336134.1
NP_001336135.1
NP_001336136.1
NP_001336137.1
NP_663731.1
XP_006711933.1
XP_006711935.1
XP_011508635.1
XP_011508636.1
XP_011508637.1
XP_011508638.1
XP_016859112.1
XP_016859113.1
XP_016859114.1
XP_016859116.1
XP_016859117.1
XP_016859118.1
XP_016859119.1
XP_016859120.1
XP_024308530.1
XP_024308531.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012843.2 RefSeqGene

    Range
    74007..154831
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001261427.2NP_001248356.1  phosphatidate phosphatase LPIN1 isoform 2

    See identical proteins and their annotated locations for NP_001248356.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (2) has a longer and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AI379040, AK294742, AK302922, BC030537, D80010, DB086946
    Consensus CDS
    CCDS58701.1
    UniProtKB/Swiss-Prot
    Q14693
    Related
    ENSP00000401522.2, ENST00000425416.6
    Conserved Domains (3) summary
    pfam04571
    Location:7113
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:632857
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:470560
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  2. NM_001261428.2NP_001248357.1  phosphatidate phosphatase LPIN1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. The encoded isoform (3) is longer compared to isoform 1.
    Source sequence(s)
    AC106875, AI379040, AK294742, BC030537, BP192775, D80010, DC334711
    Consensus CDS
    CCDS58699.1
    UniProtKB/Swiss-Prot
    Q14693
    Related
    ENSP00000397908.2, OTTHUMP00000275366, ENST00000449576.6, OTTHUMT00000475535
    Conserved Domains (4) summary
    pfam15017
    Location:940969
    AF1Q; Drug resistance and apoptosis regulator
    pfam04571
    Location:50155
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:711936
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:549639
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  3. NM_001349199.1NP_001336128.1  phosphatidate phosphatase LPIN1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Both variants 1 and 5 encode the same isoform (1).
    Source sequence(s)
    AC012456, AI379040
    Consensus CDS
    CCDS1682.1
    Conserved Domains (3) summary
    pfam04571
    Location:1107
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:626851
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:464554
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  4. NM_001349200.1NP_001336129.1  phosphatidate phosphatase LPIN1 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and contains an alternate in-frame exon in the coding region compared to variant 1. The encoded isoform (5; also known as gamma) is longer than isoform 1. Both variants 6 and 7 encode the same isoform (5).
    Source sequence(s)
    AC012456, AI379040
    Conserved Domains (3) summary
    pfam04571
    Location:1107
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:652877
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:464580
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  5. NM_001349201.1NP_001336130.1  phosphatidate phosphatase LPIN1 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) contains an alternate in-frame exon in the coding region compared to variant 1. The encoded isoform (5; also known as gamma) is longer than isoform 1. Both variants 6 and 7 encode the same isoform (5).
    Source sequence(s)
    AC012456, AI379040
    Conserved Domains (3) summary
    pfam04571
    Location:1107
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:652877
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:464580
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  6. NM_001349202.1NP_001336131.1  phosphatidate phosphatase LPIN1 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and contains an alternate in-frame exon in the coding region compared to variant 1. The encoded isoform (6) is longer than isoform 1. Both variants 8 and 9 encode the same isoform (6).
    Source sequence(s)
    AC012456, AI379040
    Conserved Domains (3) summary
    pfam04571
    Location:1107
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:661886
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:499589
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  7. NM_001349203.1NP_001336132.1  phosphatidate phosphatase LPIN1 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) contains an alternate in-frame exon in the coding region compared to variant 1. The encoded isoform (6) is longer than isoform 1. Both variants 8 and 9 encode the same isoform (6).
    Source sequence(s)
    AC012456, AI379040
    Conserved Domains (3) summary
    pfam04571
    Location:1107
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:661886
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:499589
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  8. NM_001349204.1NP_001336133.1  phosphatidate phosphatase LPIN1 isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR and contains an alternate in-frame exon in the coding region compared to variant 1. The encoded isoform (7; also known as beta) is longer than isoform 1. Variants 10-12 encode the same isoform (7).
    Source sequence(s)
    AC012456, AI379040
    Conserved Domains (3) summary
    pfam04571
    Location:1107
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:662887
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:500590
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  9. NM_001349205.1NP_001336134.1  phosphatidate phosphatase LPIN1 isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR and contains an alternate in-frame exon in the coding region compared to variant 1. The encoded isoform (7; also known as beta) is longer than isoform 1. Variants 10-12 encode the same isoform (7).
    Source sequence(s)
    AC012456, AI379040
    Conserved Domains (3) summary
    pfam04571
    Location:1107
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:662887
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:500590
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  10. NM_001349206.1NP_001336135.1  phosphatidate phosphatase LPIN1 isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) contains an alternate in-frame exon in the coding region compared to variant 1. The encoded isoform (7; also known as beta) is longer than isoform 1. Variants 10-12 encode the same isoform (7).
    Source sequence(s)
    AC012456, AI379040
    Conserved Domains (3) summary
    pfam04571
    Location:1107
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:662887
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:500590
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  11. NM_001349207.1NP_001336136.1  phosphatidate phosphatase LPIN1 isoform 8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) differs in the 5' UTR and the 5' coding region compared to variant 1. The encoded isoform (8) has a longer and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC012456, AC106875, AI379040
    Conserved Domains (3) summary
    pfam04571
    Location:31137
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:692917
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:530620
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  12. NM_001349208.1NP_001336137.1  phosphatidate phosphatase LPIN1 isoform 9

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) differs in the 5' UTR and the 5' coding region compared to variant 1. The encoded isoform (9) has a longer and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC012456, AC106875, AI379040
    Conserved Domains (3) summary
    pfam04571
    Location:50156
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:675900
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:513603
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  13. NM_145693.3NP_663731.1  phosphatidate phosphatase LPIN1 isoform 1

    See identical proteins and their annotated locations for NP_663731.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes the shortest isoform (1; also known as alpha). Both variants 1 and 5 encode the same isoform (1).
    Source sequence(s)
    AC012456, AI379040, BC030537, D80010, DB153243
    Consensus CDS
    CCDS1682.1
    UniProtKB/Swiss-Prot
    Q14693
    Related
    ENSP00000256720.2, OTTHUMP00000147624, ENST00000256720.6, OTTHUMT00000239296
    Conserved Domains (3) summary
    pfam04571
    Location:1107
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:626851
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:464554
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

RNA

  1. NR_146080.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15) uses an alternate splice site in the 3' region compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC012456, AI379040

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    11677544..11827409
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510333.2XP_011508635.1  phosphatidate phosphatase LPIN1 isoform X1

    Conserved Domains (4) summary
    pfam15017
    Location:939968
    AF1Q; Drug resistance and apoptosis regulator
    pfam04571
    Location:50155
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:710935
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:548638
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  2. XM_017003623.2XP_016859112.1  phosphatidate phosphatase LPIN1 isoform X2

  3. XM_024452762.1XP_024308530.1  phosphatidate phosphatase LPIN1 isoform X3

    Conserved Domains (3) summary
    pfam04571
    Location:1107
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:662887
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:500590
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  4. XM_006711872.3XP_006711935.1  phosphatidate phosphatase LPIN1 isoform X3

    See identical proteins and their annotated locations for XP_006711935.1

    UniProtKB/Swiss-Prot
    Q14693
    Conserved Domains (3) summary
    pfam04571
    Location:1107
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:662887
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:500590
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  5. XM_011510334.3XP_011508636.1  phosphatidate phosphatase LPIN1 isoform X4

    See identical proteins and their annotated locations for XP_011508636.1

    UniProtKB/Swiss-Prot
    Q14693
    Related
    ENSP00000379404.2, ENST00000396097.5
    Conserved Domains (4) summary
    pfam15017
    Location:897926
    AF1Q; Drug resistance and apoptosis regulator
    pfam04571
    Location:7112
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:668893
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:506596
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  6. XM_011510335.3XP_011508637.1  phosphatidate phosphatase LPIN1 isoform X3

    See identical proteins and their annotated locations for XP_011508637.1

    UniProtKB/Swiss-Prot
    Q14693
    Conserved Domains (3) summary
    pfam04571
    Location:1107
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:662887
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:500590
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  7. XM_017003627.2XP_016859116.1  phosphatidate phosphatase LPIN1 isoform X5

    Conserved Domains (3) summary
    pfam04571
    Location:1107
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:661886
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:499589
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  8. XM_017003628.2XP_016859117.1  phosphatidate phosphatase LPIN1 isoform X7

    UniProtKB/Swiss-Prot
    Q14693
    Conserved Domains (3) summary
    pfam04571
    Location:1107
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:626851
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:464554
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  9. XM_011510336.3XP_011508638.1  phosphatidate phosphatase LPIN1 isoform X3

    See identical proteins and their annotated locations for XP_011508638.1

    UniProtKB/Swiss-Prot
    Q14693
    Conserved Domains (3) summary
    pfam04571
    Location:1107
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:662887
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:500590
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  10. XM_006711870.4XP_006711933.1  phosphatidate phosphatase LPIN1 isoform X4

    See identical proteins and their annotated locations for XP_006711933.1

    UniProtKB/Swiss-Prot
    Q14693
    Conserved Domains (4) summary
    pfam15017
    Location:897926
    AF1Q; Drug resistance and apoptosis regulator
    pfam04571
    Location:7112
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:668893
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:506596
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  11. XM_024452763.1XP_024308531.1  phosphatidate phosphatase LPIN1 isoform X6

    Conserved Domains (3) summary
    pfam04571
    Location:7113
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:632857
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:470560
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  12. XM_017003624.2XP_016859113.1  phosphatidate phosphatase LPIN1 isoform X3

    UniProtKB/Swiss-Prot
    Q14693
    Conserved Domains (3) summary
    pfam04571
    Location:1107
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:662887
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:500590
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  13. XM_017003629.1XP_016859118.1  phosphatidate phosphatase LPIN1 isoform X7

    UniProtKB/Swiss-Prot
    Q14693
    Conserved Domains (3) summary
    pfam04571
    Location:1107
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:626851
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:464554
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  14. XM_017003625.2XP_016859114.1  phosphatidate phosphatase LPIN1 isoform X3

    UniProtKB/Swiss-Prot
    Q14693
    Conserved Domains (3) summary
    pfam04571
    Location:1107
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:662887
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:500590
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  15. XM_017003630.2XP_016859119.1  phosphatidate phosphatase LPIN1 isoform X7

    UniProtKB/Swiss-Prot
    Q14693
    Conserved Domains (3) summary
    pfam04571
    Location:1107
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:626851
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:464554
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  16. XM_017003631.1XP_016859120.1  phosphatidate phosphatase LPIN1 isoform X8

    Related
    ENSP00000379405.1, ENST00000396098.5

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001261429.1: Suppressed sequence

    Description
    NM_001261429.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Support Center