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Lpin1 lipin 1 [ Mus musculus (house mouse) ]

Gene ID: 14245, updated on 8-Dec-2022

Summary

Official Symbol
Lpin1provided by MGI
Official Full Name
lipin 1provided by MGI
Primary source
MGI:MGI:1891340
See related
Ensembl:ENSMUSG00000020593 AllianceGenome:MGI:1891340
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
fld; Lipin1
Summary
Enables several functions, including histone deacetylase binding activity; peroxisome proliferator activated receptor binding activity; and phosphatidate phosphatase activity. Involved in several processes, including mitochondrial fission; positive regulation of cold-induced thermogenesis; and triglyceride mobilization. Acts upstream of or within several processes, including actin cytoskeleton reorganization; positive regulation of histone deacetylation; and ruffle organization. Located in endoplasmic reticulum; mitochondrial outer membrane; and nuclear membrane. Part of transcription regulator complex. Is expressed in liver; nervous system; olfactory epithelium; and tooth. Used to study lipodystrophy. Orthologous to human LPIN1 (lipin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 79.1), subcutaneous fat pad adult (RPKM 36.4) and 17 other tissues See more
Orthologs
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Genomic context

See Lpin1 in Genome Data Viewer
Location:
12 A1.1; 12 7.9 cM
Exon count:
28
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (16585670..16697020, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (16535669..16653903, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36372 Neighboring gene predicted gene, 48606 Neighboring gene predicted gene, 53741 Neighboring gene neurotensin receptor 2 Neighboring gene gene regulated by estrogen in breast cancer protein

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • Kiaa0188, mKIAA0188, 4631420P06

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables histone deacetylase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peroxisome proliferator activated receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables phosphatidate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidate phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidate phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within actin cytoskeleton reorganization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to insulin stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cellular response to insulin stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in fat cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in fatty acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in fatty acid catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrial fission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of myelination ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of phosphatidate phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in phosphatidic acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of histone deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within ruffle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in triglyceride biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in triglyceride biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in triglyceride mobilization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
phosphatidate phosphatase LPIN1
Names
fatty liver dystrophy protein
NP_001123884.1
NP_001342527.1
NP_056578.2
NP_766538.2
XP_006515038.1
XP_006515039.1
XP_006515040.1
XP_006515041.1
XP_006515045.1
XP_006515046.1
XP_006515047.1
XP_006515049.1
XP_006515050.1
XP_011242117.1
XP_030102417.1
XP_030102419.1
XP_030102420.1
XP_036013081.1
XP_036013082.1
XP_036013083.1
XP_036013084.1
XP_036013085.1
XP_036013086.1
XP_036013087.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130412.1NP_001123884.1  phosphatidate phosphatase LPIN1 isoform a

    See identical proteins and their annotated locations for NP_001123884.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant differs in the 5' UTR, compared to variant 1. This variant encodes isoform a. Isoform a is also known as isoform alpha. Variants 1 and 3 encode the same isoform.
    Source sequence(s)
    AK009789, AK014526, AK030921, BY127780, BY209929, CK621866, CX205142
    Consensus CDS
    CCDS25823.1
    UniProtKB/Swiss-Prot
    Q91ZP3
    UniProtKB/TrEMBL
    A0A1Y7VLN4, Q8CD95
    Related
    ENSMUSP00000152276.2, ENSMUST00000222989.2
    Conserved Domains (4) summary
    pfam15017
    Location:856885
    AF1Q; Drug resistance and apoptosis regulator
    pfam04571
    Location:1106
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:627852
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:465555
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  2. NM_001355598.1NP_001342527.1  phosphatidate phosphatase LPIN1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant differs in the 5' UTR and includes an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in a longer protein (isoform b), compared to isoform a. Isoform b is also known as isoform beta. Variants 2 and 4 encode the same isoform.
    Source sequence(s)
    AC159631, AK019539
    Consensus CDS
    CCDS25822.1
    UniProtKB/TrEMBL
    A0A0R4J0V3
    Related
    ENSMUSP00000106696.4, ENSMUST00000111067.10
    Conserved Domains (3) summary
    pfam04571
    Location:1107
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:660885
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:498589
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  3. NM_015763.4NP_056578.2  phosphatidate phosphatase LPIN1 isoform b

    See identical proteins and their annotated locations for NP_056578.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in a longer protein (isoform b), compared to isoform a. Isoform b is also known as isoform beta. Variants 2 and 4 encode the same isoform.
    Source sequence(s)
    AK009789, AK014526, BY127780, CK621866, CX205142
    Consensus CDS
    CCDS25822.1
    UniProtKB/Swiss-Prot
    Q91ZP3
    UniProtKB/TrEMBL
    A0A0R4J0V3, E9QKQ5
    Related
    ENSMUSP00000070583.6, ENSMUST00000067124.6
    Conserved Domains (3) summary
    pfam04571
    Location:1107
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:660885
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:498589
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  4. NM_172950.3NP_766538.2  phosphatidate phosphatase LPIN1 isoform a

    See identical proteins and their annotated locations for NP_766538.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes the shorter isoform (a). Isoform a is also known as isoform alpha. Variants 1 and 3 encode the same isoform.
    Source sequence(s)
    AK009789, AK014526, AK030921, BY127780, CK621866, CX205142
    Consensus CDS
    CCDS25823.1
    UniProtKB/Swiss-Prot
    Q91ZP3
    UniProtKB/TrEMBL
    A0A1Y7VLN4, Q8CD95
    Related
    ENSMUSP00000152466.2, ENSMUST00000221230.2
    Conserved Domains (4) summary
    pfam15017
    Location:856885
    AF1Q; Drug resistance and apoptosis regulator
    pfam04571
    Location:1106
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:627852
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:465555
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    16585670..16697020 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514975.4XP_006515038.1  phosphatidate phosphatase LPIN1 isoform X1

    Conserved Domains (4) summary
    pfam04571
    Location:61166
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:746971
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam15402
    Location:237429
    Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7
    pfam16876
    Location:558631
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  2. XM_036157191.1XP_036013084.1  phosphatidate phosphatase LPIN1 isoform X11

    UniProtKB/TrEMBL
    A0A0R4J0V3
    Conserved Domains (3) summary
    pfam04571
    Location:1107
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:660885
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:498589
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  3. XM_006514977.4XP_006515040.1  phosphatidate phosphatase LPIN1 isoform X4

    Related
    ENSMUSP00000158955.2, ENSMUST00000238839.2
    Conserved Domains (4) summary
    pfam04571
    Location:61166
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:720945
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam15402
    Location:237429
    Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7
    pfam16876
    Location:558648
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  4. XM_030246557.2XP_030102417.1  phosphatidate phosphatase LPIN1 isoform X5

    Conserved Domains (4) summary
    pfam04571
    Location:61166
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:719944
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam15402
    Location:237428
    Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7
    pfam16876
    Location:557647
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  5. XM_006514982.5XP_006515045.1  phosphatidate phosphatase LPIN1 isoform X6

    Conserved Domains (3) summary
    pfam04571
    Location:61166
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:687912
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:525615
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  6. XM_036157189.1XP_036013082.1  phosphatidate phosphatase LPIN1 isoform X10

    Conserved Domains (3) summary
    pfam04571
    Location:21127
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:680905
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:518609
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  7. XM_036157188.1XP_036013081.1  phosphatidate phosphatase LPIN1 isoform X9

    Conserved Domains (3) summary
    pfam04571
    Location:25131
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:684909
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:522613
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  8. XM_036157190.1XP_036013083.1  phosphatidate phosphatase LPIN1 isoform X10

    Conserved Domains (3) summary
    pfam04571
    Location:21127
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:680905
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:518609
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  9. XM_030246559.2XP_030102419.1  phosphatidate phosphatase LPIN1 isoform X13

    Conserved Domains (3) summary
    pfam04571
    Location:1106
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:653878
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:465538
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  10. XM_036157193.1XP_036013086.1  phosphatidate phosphatase LPIN1 isoform X12

    Conserved Domains (3) summary
    pfam04571
    Location:1107
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:659884
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:497588
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  11. XM_036157192.1XP_036013085.1  phosphatidate phosphatase LPIN1 isoform X11

    UniProtKB/TrEMBL
    A0A0R4J0V3
    Related
    ENSMUSP00000152285.2, ENSMUST00000221297.2
    Conserved Domains (3) summary
    pfam04571
    Location:1107
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:660885
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:498589
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  12. XM_006514978.5XP_006515041.1  phosphatidate phosphatase LPIN1 isoform X3

    Conserved Domains (3) summary
    pfam04571
    Location:61166
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:713938
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:525598
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  13. XM_006514976.5XP_006515039.1  phosphatidate phosphatase LPIN1 isoform X2

    Conserved Domains (4) summary
    pfam04571
    Location:61166
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:745970
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam15402
    Location:237428
    Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7
    pfam16876
    Location:557630
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  14. XM_006514987.5XP_006515050.1  phosphatidate phosphatase LPIN1 isoform X8

    Conserved Domains (4) summary
    pfam04571
    Location:1106
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:685910
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam15402
    Location:177368
    Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7
    pfam16876
    Location:497570
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  15. XM_006514983.5XP_006515046.1  phosphatidate phosphatase LPIN1 isoform X7

    See identical proteins and their annotated locations for XP_006515046.1

    UniProtKB/TrEMBL
    A0A5F8MQ53
    Related
    ENSMUSP00000159076.2, ENSMUST00000239165.2
    Conserved Domains (4) summary
    pfam04571
    Location:1106
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:686911
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam15402
    Location:177369
    Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7
    pfam16876
    Location:498571
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  16. XM_011243815.4XP_011242117.1  phosphatidate phosphatase LPIN1 isoform X14

    Conserved Domains (2) summary
    pfam08235
    Location:505730
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:317434
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  17. XM_006514984.5XP_006515047.1  phosphatidate phosphatase LPIN1 isoform X7

    See identical proteins and their annotated locations for XP_006515047.1

    UniProtKB/TrEMBL
    A0A5F8MQ53
    Conserved Domains (4) summary
    pfam04571
    Location:1106
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:686911
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam15402
    Location:177369
    Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7
    pfam16876
    Location:498571
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  18. XM_036157194.1XP_036013087.1  phosphatidate phosphatase LPIN1 isoform X14

    Conserved Domains (2) summary
    pfam08235
    Location:505730
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:317434
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  19. XM_030246560.2XP_030102420.1  phosphatidate phosphatase LPIN1 isoform X13

    Conserved Domains (3) summary
    pfam04571
    Location:1106
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:653878
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:465538
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  20. XM_006514986.5XP_006515049.1  phosphatidate phosphatase LPIN1 isoform X7

    See identical proteins and their annotated locations for XP_006515049.1

    UniProtKB/TrEMBL
    A0A5F8MQ53
    Conserved Domains (4) summary
    pfam04571
    Location:1106
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:686911
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam15402
    Location:177369
    Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7
    pfam16876
    Location:498571
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain