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MPRIP myosin phosphatase Rho interacting protein [ Homo sapiens (human) ]

Gene ID: 23164, updated on 3-Nov-2024

Summary

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Official Symbol
MPRIPprovided by HGNC
Official Full Name
myosin phosphatase Rho interacting proteinprovided by HGNC
Primary source
HGNC:HGNC:30321
See related
Ensembl:ENSG00000133030 MIM:612935; AllianceGenome:HGNC:30321
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRIP; RIP3; M-RIP; RHOIP3; p116Rip
Summary
Enables cadherin binding activity. Located in actin cytoskeleton and cytosol. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in endometrium (RPKM 19.8), brain (RPKM 18.4) and 25 other tissues See more
Orthologs
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Genomic context

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See MPRIP in Genome Data Viewer
Location:
17p11.2
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (17042457..17192643)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (16988540..17138696)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (16945771..17095957)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11784 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:16899244-16899806 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11785 Neighboring gene long intergenic non-protein coding RNA 2090 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:16908048-16908576 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:16914402-16915394 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:16923086-16924033 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:16932678-16933252 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11786 Neighboring gene uncharacterized LOC124903938 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8233 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:16946458-16947657 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:16959278-16959917 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:16975468-16975993 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:16975994-16976520 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:16991083-16991584 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:16999002-16999588 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11787 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:17011600-17012124 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:17022544-17023069 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17029831-17030330 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17030795-17031296 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17031297-17031796 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:17034927-17035431 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11788 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:17043984-17044574 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17045275-17045817 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17045818-17046359 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11789 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17070554-17071156 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17074887-17075546 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17075547-17076206 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11790 Neighboring gene RNA, U6 small nuclear 767, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17088115-17088615 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11792 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11791 Neighboring gene RNA, 7SL, cytoplasmic 775, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:17094445-17095112 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:17095113-17095778 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8234 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11793 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8235 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8236 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8237 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:17109841-17110680 Neighboring gene phospholipase D family member 6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17132411-17132910 Neighboring gene folliculin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The F-Actin-Binding MPRIP Forms Phase-Separated Condensates and Associates with PI(4,5)P2 and Active RNA Polymerase II in the Cell Nucleus. Balaban C, et al. Cells, 2021 Apr 8. PMID 33918018, Free PMC Article
  2. PIP2-Effector Protein MPRIP Regulates RNA Polymerase II Condensation and Transcription. Balaban C, et al. Biomolecules, 2023 Feb 24. PMID 36979361, Free PMC Article
  3. M-RIP targets myosin phosphatase to stress fibers to regulate myosin light chain phosphorylation in vascular smooth muscle cells. Surks HK, et al. J Biol Chem, 2005 Dec 30. PMID 16257966
  4. Association of syntenin-1 with M-RIP polarizes Rac-1 activation during chemotaxis and immune interactions. Sala-Valdés M, et al. J Cell Sci, 2012 Mar 1. PMID 22349701
  5. An association between NUAK2 and MRIP reveals a novel mechanism for regulation of actin stress fibers. Vallenius T, et al. J Cell Sci, 2011 Feb 1. PMID 21242312

See all (135) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. [circDDX17 targets miR-223-3p / RIP3 to regulate the proliferation and apoptosis of non-small cell lung cancer cells].
    Title: [circDDX17 targets miR-223-3p / RIP3 to regulate the proliferation and apoptosis of non-small cell lung cancer cells].
  2. PIP2-Effector Protein MPRIP Regulates RNA Polymerase II Condensation and Transcription.
    Title: PIP2-Effector Protein MPRIP Regulates RNA Polymerase II Condensation and Transcription.
  3. The F-Actin-Binding MPRIP Forms Phase-Separated Condensates and Associates with PI(4,5)P2 and Active RNA Polymerase II in the Cell Nucleus.
    Title: The F-Actin-Binding MPRIP Forms Phase-Separated Condensates and Associates with PI(4,5)P2 and Active RNA Polymerase II in the Cell Nucleus.
  4. The B-Raf(V600E) inhibitor dabrafenib selectively inhibits RIP3 and alleviates acetaminophen-induced liver injury.
    Title: The B-Raf(V600E) inhibitor dabrafenib selectively inhibits RIP3 and alleviates acetaminophen-induced liver injury.
  5. Our data identify M-RIP as a crucial local regulator of the Rho-Rac balance during chemotaxis and antigen recognition.
    Title: Association of syntenin-1 with M-RIP polarizes Rac-1 activation during chemotaxis and immune interactions.
  6. MLCP (myosin light chain phosphatase) activation is counteracted by a previously unrecognized association between MRIP and the inducible kinase NUAK2
    Title: An association between NUAK2 and MRIP reveals a novel mechanism for regulation of actin stress fibers.
  7. A functional analysis of JNK1 and M-RIP with RNA interference reveals a critical role for this cascade in the invasive behavior of cancer cells.
    Title: M-RIP, a novel target of JNK signaling and a requirement for human cancer cell invasion.
  8. p116Rip is an important regulatory component that controls the RhoA signaling pathway, thus regulating MLCP activity and myosin phosphorylation in cells
    Title: p116Rip decreases myosin II phosphorylation by activating myosin light chain phosphatase and by inactivating RhoA.
  9. M-RIP-dependent targeting of myosin phosphatase to stress fibers has an important role in regulating myosin light chain phosphorylation state and morphology in human vascular smooth muscle cells
    Title: M-RIP targets myosin phosphatase to stress fibers to regulate myosin light chain phosphorylation in vascular smooth muscle cells.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide meta-analysis for severe diabetic retinopathy.
EBI GWAS Catalog
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0864

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cadherin binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in focal adhesion HDA PubMed 

General protein information

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Preferred Names
myosin phosphatase Rho-interacting protein
Names
Rho interacting protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364716.4 → NP_001351645.2  myosin phosphatase Rho-interacting protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC055811, AC079111, AC104024
    Consensus CDS
    CCDS92265.1
    UniProtKB/TrEMBL
    A0A494BZV2
    Related
    ENSP00000498253.1, ENST00000651222.2
    Conserved Domains (6) summary
    PHA03307
    Location:303 → 502
    PHA03307; transcriptional regulator ICP4; Provisional
    COG1196
    Location:2061 → 2362
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01236
    Location:16 → 151
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    cd13275
    Location:508 → 609
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    TIGR02168
    Location:797 → 1159
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02169
    Location:1860 → 2168
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  2. NM_015134.4 → NP_055949.2  myosin phosphatase Rho-interacting protein isoform 1

    See identical proteins and their annotated locations for NP_055949.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC055811, AC079111, AC104024, AK092287, BC009982, BC136479
    Consensus CDS
    CCDS42268.1
    UniProtKB/TrEMBL
    B9EGI2
    Related
    ENSP00000379156.4, ENST00000395811.9
    Conserved Domains (6) summary
    cd01236
    Location:16 → 151
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    cd13275
    Location:390 → 491
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    pfam00169
    Location:390 → 483
    PH; PH domain
    cd16269
    Location:760 → 771
    GBP_C; coiled coil [structural motif]
    cl02488
    Location:738 → 980
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl20817
    Location:679 → 788
    GBP_C; Guanylate-binding protein, C-terminal domain

  3. NM_201274.4 → NP_958431.2  myosin phosphatase Rho-interacting protein isoform 2

    See identical proteins and their annotated locations for NP_958431.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate exon in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC055811, AC079111, AC104024, AY296247, BC075847, BE048871
    Consensus CDS
    CCDS32578.1
    UniProtKB/Swiss-Prot
    Q3KQZ5, Q5FB94, Q6DHW2, Q6WCQ1, Q7Z5Y2, Q8N390, Q96G40
    UniProtKB/TrEMBL
    B9EGI2
    Related
    ENSP00000342379.4, ENST00000341712.8
    Conserved Domains (6) summary
    cd01236
    Location:16 → 151
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    cd13275
    Location:390 → 491
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    pfam00169
    Location:390 → 483
    PH; PH domain
    cd16269
    Location:760 → 771
    GBP_C; coiled coil [structural motif]
    cl02488
    Location:738 → 980
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl20817
    Location:679 → 788
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    17042457..17192643
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011523764.3 → XP_011522066.1  myosin phosphatase Rho-interacting protein isoform X2

    Conserved Domains (9) summary
    cd01236
    Location:48 → 183
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    cd13275
    Location:540 → 641
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    pfam00169
    Location:540 → 633
    PH; PH domain
    pfam10473
    Location:1062 → 1190
    CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
    pfam15619
    Location:885 → 1036
    Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
    pfam16043
    Location:1048 → 1191
    DUF4795; Domain of unknown function (DUF4795)
    cl02488
    Location:2157 → 2314
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl12013
    Location:928 → 1117
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl19219
    Location:2098 → 2198
    DUF342; Protein of unknown function (DUF342)

  2. XM_011523766.3 → XP_011522068.2  myosin phosphatase Rho-interacting protein isoform X5

    UniProtKB/TrEMBL
    B9EGI2

  3. XM_047435685.1 → XP_047291641.1  myosin phosphatase Rho-interacting protein isoform X7

  4. XM_011523763.3 → XP_011522065.1  myosin phosphatase Rho-interacting protein isoform X1

    Conserved Domains (8) summary
    cd01236
    Location:48 → 183
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    cd13275
    Location:502 → 603
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    pfam00169
    Location:502 → 595
    PH; PH domain
    pfam10473
    Location:1024 → 1152
    CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
    pfam15619
    Location:847 → 998
    Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
    pfam16043
    Location:1010 → 1153
    DUF4795; Domain of unknown function (DUF4795)
    cl03951
    Location:2080 → 2179
    CDC37_N; Cdc37 N terminal kinase binding
    cl12013
    Location:890 → 1079
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  5. XM_047435684.1 → XP_047291640.1  myosin phosphatase Rho-interacting protein isoform X6

  6. XM_005256563.5 → XP_005256620.1  myosin phosphatase Rho-interacting protein isoform X3

    Conserved Domains (7) summary
    cd01236
    Location:48 → 183
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    cd13275
    Location:422 → 523
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    pfam00169
    Location:422 → 515
    PH; PH domain
    pfam10473
    Location:944 → 1072
    CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
    pfam15619
    Location:767 → 918
    Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
    cl03951
    Location:2000 → 2099
    CDC37_N; Cdc37 N terminal kinase binding
    cl12013
    Location:828 → 999
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  7. XM_047435683.1 → XP_047291639.1  myosin phosphatase Rho-interacting protein isoform X4

  8. XM_047435686.1 → XP_047291642.1  myosin phosphatase Rho-interacting protein isoform X9

  9. XM_005256564.5 → XP_005256621.3  myosin phosphatase Rho-interacting protein isoform X8

    UniProtKB/TrEMBL
    B9EGI2
    Related
    ENSP00000462688.1, ENST00000584067.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    16988540..17138696
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054315583.1 → XP_054171558.1  myosin phosphatase Rho-interacting protein isoform X11

  2. XM_054315586.1 → XP_054171561.1  myosin phosphatase Rho-interacting protein isoform X14

  3. XM_054315588.1 → XP_054171563.1  myosin phosphatase Rho-interacting protein isoform X16

  4. XM_054315582.1 → XP_054171557.1  myosin phosphatase Rho-interacting protein isoform X10

  5. XM_054315587.1 → XP_054171562.1  myosin phosphatase Rho-interacting protein isoform X15

  6. XM_054315584.1 → XP_054171559.1  myosin phosphatase Rho-interacting protein isoform X12

  7. XM_054315585.1 → XP_054171560.1  myosin phosphatase Rho-interacting protein isoform X13

  8. XM_054315590.1 → XP_054171565.1  myosin phosphatase Rho-interacting protein isoform X18

  9. XM_054315589.1 → XP_054171564.1  myosin phosphatase Rho-interacting protein isoform X17

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6WCQ1.3 GenPept UniProtKB/Swiss-Prot:Q6WCQ1

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