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MPRIP myosin phosphatase Rho interacting protein [ Homo sapiens (human) ]

Gene ID: 23164, updated on 1-Jun-2020

Summary

Official Symbol
MPRIPprovided by HGNC
Official Full Name
myosin phosphatase Rho interacting proteinprovided by HGNC
Primary source
HGNC:HGNC:30321
See related
Ensembl:ENSG00000133030 MIM:612935
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRIP; RIP3; M-RIP; RHOIP3; p116Rip
Expression
Ubiquitous expression in endometrium (RPKM 19.8), brain (RPKM 18.4) and 25 other tissues See more
Orthologs

Genomic context

See MPRIP in Genome Data Viewer
Location:
17p11.2
Exon count:
25
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (17042455..17192648)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (16945790..17095962)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC284191 Neighboring gene long intergenic non-protein coding RNA 2090 Neighboring gene Sharpr-MPRA regulatory region 13867 Neighboring gene RNA, U6 small nuclear 767, pseudogene Neighboring gene RNA, 7SL, cytoplasmic 775, pseudogene Neighboring gene phospholipase D family member 6 Neighboring gene folliculin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide meta-analysis for severe diabetic retinopathy.
NHGRI GWA Catalog
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0864

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding IEA
Inferred from Electronic Annotation
more info
 
actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cadherin binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
focal adhesion HDA PubMed 

General protein information

Preferred Names
myosin phosphatase Rho-interacting protein
Names
Rho interacting protein 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364716.4NP_001351645.2  myosin phosphatase Rho-interacting protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC055811, AC079111, AC104024
    Related
    ENSP00000498253.1, ENST00000651222.1
  2. NM_015134.4NP_055949.2  myosin phosphatase Rho-interacting protein isoform 1

    See identical proteins and their annotated locations for NP_055949.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC055811, AC079111, AC104024, AK092287, BC009982, BC136479
    Consensus CDS
    CCDS42268.1
    UniProtKB/Swiss-Prot
    Q6WCQ1
    UniProtKB/TrEMBL
    Q8N236
    Related
    ENSP00000379156.4, ENST00000395811.9
    Conserved Domains (6) summary
    cd01236
    Location:16151
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    cd13275
    Location:390491
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    pfam00169
    Location:390483
    PH; PH domain
    cd16269
    Location:760771
    GBP_C; coiled coil [structural motif]
    cl02488
    Location:738980
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl20817
    Location:679788
    GBP_C; Guanylate-binding protein, C-terminal domain
  3. NM_201274.4NP_958431.2  myosin phosphatase Rho-interacting protein isoform 2

    See identical proteins and their annotated locations for NP_958431.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate exon in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC055811, AC079111, AC104024, AY296247, BC075847, BE048871
    Consensus CDS
    CCDS32578.1
    UniProtKB/Swiss-Prot
    Q6WCQ1
    Related
    ENSP00000342379.4, ENST00000341712.8
    Conserved Domains (6) summary
    cd01236
    Location:16151
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    cd13275
    Location:390491
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    pfam00169
    Location:390483
    PH; PH domain
    cd16269
    Location:760771
    GBP_C; coiled coil [structural motif]
    cl02488
    Location:738980
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl20817
    Location:679788
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    17042455..17192648
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011523762.2XP_011522064.1  myosin phosphatase Rho-interacting protein isoform X2

    Conserved Domains (8) summary
    cd01236
    Location:48183
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    cd13275
    Location:540641
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    pfam00169
    Location:540633
    PH; PH domain
    pfam10473
    Location:10621190
    CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
    pfam15619
    Location:8851036
    Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
    pfam16043
    Location:10481191
    DUF4795; Domain of unknown function (DUF4795)
    cl03951
    Location:21182217
    CDC37_N; Cdc37 N terminal kinase binding
    cl12013
    Location:9281117
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  2. XM_011523765.2XP_011522067.1  myosin phosphatase Rho-interacting protein isoform X5

    Conserved Domains (9) summary
    cd01236
    Location:48183
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    cd13275
    Location:540641
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    pfam00169
    Location:540633
    PH; PH domain
    pfam10473
    Location:10621190
    CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
    pfam15619
    Location:8851036
    Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
    pfam16043
    Location:10481191
    DUF4795; Domain of unknown function (DUF4795)
    cl02488
    Location:21572314
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl12013
    Location:9281117
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl19219
    Location:20982198
    DUF342; Protein of unknown function (DUF342)
  3. XM_011523764.2XP_011522066.1  myosin phosphatase Rho-interacting protein isoform X4

    Conserved Domains (9) summary
    cd01236
    Location:48183
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    cd13275
    Location:540641
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    pfam00169
    Location:540633
    PH; PH domain
    pfam10473
    Location:10621190
    CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
    pfam15619
    Location:8851036
    Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
    pfam16043
    Location:10481191
    DUF4795; Domain of unknown function (DUF4795)
    cl02488
    Location:21572314
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl12013
    Location:9281117
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl19219
    Location:20982198
    DUF342; Protein of unknown function (DUF342)
  4. XM_011523767.2XP_011522069.2  myosin phosphatase Rho-interacting protein isoform X8

  5. XM_017024393.1XP_016879882.1  myosin phosphatase Rho-interacting protein isoform X9

  6. XM_011523766.2XP_011522068.2  myosin phosphatase Rho-interacting protein isoform X7

  7. XM_011523763.2XP_011522065.1  myosin phosphatase Rho-interacting protein isoform X3

    Conserved Domains (8) summary
    cd01236
    Location:48183
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    cd13275
    Location:502603
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    pfam00169
    Location:502595
    PH; PH domain
    pfam10473
    Location:10241152
    CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
    pfam15619
    Location:847998
    Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
    pfam16043
    Location:10101153
    DUF4795; Domain of unknown function (DUF4795)
    cl03951
    Location:20802179
    CDC37_N; Cdc37 N terminal kinase binding
    cl12013
    Location:8901079
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  8. XM_005256563.4XP_005256620.1  myosin phosphatase Rho-interacting protein isoform X6

    Conserved Domains (7) summary
    cd01236
    Location:48183
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    cd13275
    Location:422523
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    pfam00169
    Location:422515
    PH; PH domain
    pfam10473
    Location:9441072
    CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
    pfam15619
    Location:767918
    Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
    cl03951
    Location:20002099
    CDC37_N; Cdc37 N terminal kinase binding
    cl12013
    Location:828999
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  9. XM_005256564.4XP_005256621.3  myosin phosphatase Rho-interacting protein isoform X10

    Related
    ENSP00000462688.1, ENST00000584067.5
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