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FCHO1 FCH and mu domain containing endocytic adaptor 1 [ Homo sapiens (human) ]

Gene ID: 23149, updated on 9-Feb-2020

Summary

Official Symbol
FCHO1provided by HGNC
Official Full Name
FCH and mu domain containing endocytic adaptor 1provided by HGNC
Primary source
HGNC:HGNC:29002
See related
Ensembl:ENSG00000130475 MIM:613437
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in lymph node (RPKM 7.7), spleen (RPKM 6.3) and 14 other tissues See more
Orthologs

Genomic context

See FCHO1 in Genome Data Viewer
Location:
19p13.11
Exon count:
30
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (17747718..17788562)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (17858527..17899377)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene unc-13 homolog A Neighboring gene microtubule associated protein 1S Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 Neighboring gene insulin like 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0290

Gene Ontology Provided by GOA

Function Evidence Code Pubs
AP-2 adaptor complex binding IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeletal protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
clathrin coat assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
clathrin coat assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
clathrin-dependent endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
clathrin-dependent endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
membrane organization TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
clathrin-coated pit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
clathrin-coated pit IDA
Inferred from Direct Assay
more info
PubMed 
clathrin-coated vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT colocalizes_with clathrin-coated vesicle IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
F-BAR domain only protein 1
Names
FCH domain only 1
FCH domain only protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161357.2NP_001154829.1  F-BAR domain only protein 1 isoform a

    See identical proteins and their annotated locations for NP_001154829.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC008761, AK303623, BC028021, BI756664, BQ433639
    Consensus CDS
    CCDS59365.1
    UniProtKB/Swiss-Prot
    O14526
    UniProtKB/TrEMBL
    A0A0C3SFZ9
    Related
    ENSP00000473001.1, ENST00000594202.5
    Conserved Domains (3) summary
    cd07674
    Location:10270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    cl10970
    Location:627882
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
    cl26464
    Location:253562
    Atrophin-1; Atrophin-1 family
  2. NM_001161358.2NP_001154830.1  F-BAR domain only protein 1 isoform b

    See identical proteins and their annotated locations for NP_001154830.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate splice site in the 3' coding region compared to variant 1, that results in a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Both variants 2 and 3 encode the same isoform (b).
    Source sequence(s)
    AC008761, AK291410, AK303623, BC041130, BI756664, BQ433639
    Consensus CDS
    CCDS32955.1
    UniProtKB/Swiss-Prot
    O14526
    Related
    ENSP00000470493.1, ENST00000600676.5
    Conserved Domains (3) summary
    cd07674
    Location:10270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    cl10970
    Location:627888
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
    cl26464
    Location:253562
    Atrophin-1; Atrophin-1 family
  3. NM_001161359.2NP_001154831.1  F-BAR domain only protein 1 isoform c

    See identical proteins and their annotated locations for NP_001154831.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. This variant (4) also uses an alternate splice site in the 3' coding region compared to variant 1, that results in a frameshift. The resulting isoform (c) is shorter and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC008761, AK303623, AK316458, BC041130, BQ433639, DB158605
    Consensus CDS
    CCDS59366.1
    UniProtKB/Swiss-Prot
    O14526
    UniProtKB/TrEMBL
    B7ZAZ3
    Related
    ENSP00000472668.1, ENST00000595033.5
    Conserved Domains (2) summary
    cl10970
    Location:577838
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
    cl12013
    Location:1220
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  4. NM_015122.3NP_055937.1  F-BAR domain only protein 1 isoform b

    See identical proteins and their annotated locations for NP_055937.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate splice site in the 3' coding region compared to variant 1, that results in a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Both variants 2 and 3 encode the same isoform (b).
    Source sequence(s)
    AC008761, AK303623, BC041130, BQ433639, DB158605
    Consensus CDS
    CCDS32955.1
    UniProtKB/Swiss-Prot
    O14526
    Conserved Domains (3) summary
    cd07674
    Location:10270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    cl10970
    Location:627888
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
    cl26464
    Location:253562
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    17747718..17788562
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527824.2XP_011526126.1  F-BAR domain only protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011526126.1

    UniProtKB/Swiss-Prot
    O14526
    Conserved Domains (3) summary
    cd07674
    Location:10270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    cl10970
    Location:627888
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
    cl26464
    Location:253562
    Atrophin-1; Atrophin-1 family
  2. XM_017026522.1XP_016882011.1  F-BAR domain only protein 1 isoform X2

  3. XM_017026526.1XP_016882015.1  F-BAR domain only protein 1 isoform X3

    Conserved Domains (2) summary
    cd07674
    Location:10270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    cd09268
    Location:535796
    FCHo1_MHD; mu-homology domain (MHD) of F-BAR domain-containing Fer/Cip4 homology domain-only protein 1 (FCH domain only 1 or FCHo1, also known as KIAA0290) and similar proteins
  4. XM_024451428.1XP_024307196.1  F-BAR domain only protein 1 isoform X1

    Conserved Domains (3) summary
    cd07674
    Location:10270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    cl10970
    Location:627888
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
    cl26464
    Location:253562
    Atrophin-1; Atrophin-1 family
  5. XM_024451427.1XP_024307195.1  F-BAR domain only protein 1 isoform X1

    Conserved Domains (3) summary
    cd07674
    Location:10270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    cl10970
    Location:627888
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
    cl26464
    Location:253562
    Atrophin-1; Atrophin-1 family
  6. XM_017026527.2XP_016882016.1  F-BAR domain only protein 1 isoform X3

    Conserved Domains (2) summary
    cd07674
    Location:10270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    cd09268
    Location:535796
    FCHo1_MHD; mu-homology domain (MHD) of F-BAR domain-containing Fer/Cip4 homology domain-only protein 1 (FCH domain only 1 or FCHo1, also known as KIAA0290) and similar proteins
  7. XM_017026520.2XP_016882009.1  F-BAR domain only protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O14526
    Conserved Domains (3) summary
    cd07674
    Location:10270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    cl10970
    Location:627888
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
    cl26464
    Location:253562
    Atrophin-1; Atrophin-1 family
  8. XM_024451429.1XP_024307197.1  F-BAR domain only protein 1 isoform X4

    Conserved Domains (2) summary
    cl10970
    Location:411672
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
    cl28033
    Location:58360
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  9. XM_011527826.3XP_011526128.1  F-BAR domain only protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011526128.1

    UniProtKB/Swiss-Prot
    O14526
    Conserved Domains (3) summary
    cd07674
    Location:10270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    cl10970
    Location:627888
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
    cl26464
    Location:253562
    Atrophin-1; Atrophin-1 family
  10. XM_017026525.1XP_016882014.1  F-BAR domain only protein 1 isoform X2

  11. XM_005259831.4XP_005259888.1  F-BAR domain only protein 1 isoform X4

    Conserved Domains (2) summary
    cl10970
    Location:411672
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
    cl28033
    Location:58360
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  12. XM_006722702.4XP_006722765.1  F-BAR domain only protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006722765.1

    UniProtKB/Swiss-Prot
    O14526
    Conserved Domains (3) summary
    cd07674
    Location:10270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    cl10970
    Location:627888
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
    cl26464
    Location:253562
    Atrophin-1; Atrophin-1 family
  13. XM_017026524.2XP_016882013.1  F-BAR domain only protein 1 isoform X2

  14. XM_006722701.4XP_006722764.1  F-BAR domain only protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006722764.1

    UniProtKB/Swiss-Prot
    O14526
    Conserved Domains (3) summary
    cd07674
    Location:10270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    cl10970
    Location:627888
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
    cl26464
    Location:253562
    Atrophin-1; Atrophin-1 family
  15. XM_017026521.2XP_016882010.1  F-BAR domain only protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O14526
    Conserved Domains (3) summary
    cd07674
    Location:10270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    cl10970
    Location:627888
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
    cl26464
    Location:253562
    Atrophin-1; Atrophin-1 family
  16. XM_024451430.1XP_024307198.1  F-BAR domain only protein 1 isoform X4

    Conserved Domains (2) summary
    cl10970
    Location:411672
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
    cl28033
    Location:58360
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  17. XM_017026519.1XP_016882008.1  F-BAR domain only protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O14526
    Conserved Domains (3) summary
    cd07674
    Location:10270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    cl10970
    Location:627888
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
    cl26464
    Location:253562
    Atrophin-1; Atrophin-1 family
  18. XM_017026523.1XP_016882012.1  F-BAR domain only protein 1 isoform X2

  19. XM_017026528.1XP_016882017.1  F-BAR domain only protein 1 isoform X3

    Conserved Domains (2) summary
    cd07674
    Location:10270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    cd09268
    Location:535796
    FCHo1_MHD; mu-homology domain (MHD) of F-BAR domain-containing Fer/Cip4 homology domain-only protein 1 (FCH domain only 1 or FCHo1, also known as KIAA0290) and similar proteins
  20. XM_011527825.2XP_011526127.1  F-BAR domain only protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011526127.1

    UniProtKB/Swiss-Prot
    O14526
    Related
    ENSP00000470731.1, ENST00000596536.5
    Conserved Domains (3) summary
    cd07674
    Location:10270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    cl10970
    Location:627888
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
    cl26464
    Location:253562
    Atrophin-1; Atrophin-1 family
  21. XM_011527828.2XP_011526130.1  F-BAR domain only protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011526130.1

    UniProtKB/Swiss-Prot
    O14526
    Conserved Domains (3) summary
    cd07674
    Location:10270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    cl10970
    Location:627888
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
    cl26464
    Location:253562
    Atrophin-1; Atrophin-1 family
  22. XM_024451431.1XP_024307199.1  F-BAR domain only protein 1 isoform X5

    Conserved Domains (1) summary
    cl12013
    Location:10270
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  23. XM_011527827.2XP_011526129.1  F-BAR domain only protein 1 isoform X3

    Conserved Domains (2) summary
    cd07674
    Location:10270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    cd09268
    Location:535796
    FCHo1_MHD; mu-homology domain (MHD) of F-BAR domain-containing Fer/Cip4 homology domain-only protein 1 (FCH domain only 1 or FCHo1, also known as KIAA0290) and similar proteins

RNA

  1. XR_002958285.1 RNA Sequence

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