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FCHO1 FCH and mu domain containing endocytic adaptor 1 [ Homo sapiens (human) ]

Gene ID: 23149, updated on 6-Jun-2024

Summary

Official Symbol
FCHO1provided by HGNC
Official Full Name
FCH and mu domain containing endocytic adaptor 1provided by HGNC
Primary source
HGNC:HGNC:29002
See related
Ensembl:ENSG00000130475 MIM:613437; AllianceGenome:HGNC:29002
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IMD76
Summary
Enables AP-2 adaptor complex binding activity. Involved in clathrin coat assembly and clathrin-dependent endocytosis. Located in cytosol; nucleoplasm; and plasma membrane. Is active in clathrin-coated pit. Implicated in primary immunodeficiency disease. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lymph node (RPKM 7.7), spleen (RPKM 6.3) and 14 other tissues See more
Orthologs
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Genomic context

See FCHO1 in Genome Data Viewer
Location:
19p13.11
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (17747744..17788561)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (17881862..17922647)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (17858553..17899370)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17715726-17716630 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17716631-17717535 Neighboring gene unc-13 homolog A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14280 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14281 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:17797343-17798304 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:17798305-17799265 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:17812168-17812395 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:17828319-17828820 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10358 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14282 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14283 Neighboring gene uncharacterized LOC124904649 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:17849672-17850172 Neighboring gene microtubule associated protein 1S Neighboring gene Sharpr-MPRA regulatory region 7159 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10359 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr19:17864444-17864964 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr19:17864965-17865484 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14284 Neighboring gene MPRA-validated peak3395 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:17877027-17877564 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14285 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:17905145-17905842 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:17905843-17906540 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 Neighboring gene insulin like 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA0290

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables AP-2 adaptor complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in clathrin coat assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in clathrin coat assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in clathrin-dependent endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in clathrin-dependent endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of T cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in clathrin-coated pit IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in clathrin-coated pit IDA
Inferred from Direct Assay
more info
PubMed 
located_in clathrin-coated pit IDA
Inferred from Direct Assay
more info
PubMed 
NOT colocalizes_with clathrin-coated vesicle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
F-BAR domain only protein 1
Names
FCH domain only 1
FCH domain only protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161357.2NP_001154829.1  F-BAR domain only protein 1 isoform a

    See identical proteins and their annotated locations for NP_001154829.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC008761, AK303623, BC028021, BI756664, BQ433639
    Consensus CDS
    CCDS59365.1
    UniProtKB/TrEMBL
    A0A0C3SFZ9, A0A8V8TPN1
    Related
    ENSP00000473001.1, ENST00000594202.6
    Conserved Domains (3) summary
    cd07674
    Location:10270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    cl10970
    Location:627882
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
    cl26464
    Location:253562
    Atrophin-1; Atrophin-1 family
  2. NM_001161358.2NP_001154830.1  F-BAR domain only protein 1 isoform b

    See identical proteins and their annotated locations for NP_001154830.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate splice site in the 3' coding region compared to variant 1, that results in a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 2, 3, and 5-16 all encode the same isoform (b).
    Source sequence(s)
    AC008761, AK291410, AK303623, BC041130, BI756664, BQ433639
    Consensus CDS
    CCDS32955.1
    UniProtKB/Swiss-Prot
    A6NHE6, A8K5U5, B4E120, O14526, Q05C93, Q8IW22
    UniProtKB/TrEMBL
    A0A8V8TPN1
    Related
    ENSP00000470493.1, ENST00000600676.5
    Conserved Domains (3) summary
    cd07674
    Location:10270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    PHA03247
    Location:253562
    PHA03247; large tegument protein UL36; Provisional
    cl10970
    Location:627888
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
  3. NM_001161359.2NP_001154831.1  F-BAR domain only protein 1 isoform c

    See identical proteins and their annotated locations for NP_001154831.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. This variant (4) also uses an alternate splice site in the 3' coding region compared to variant 1, that results in a frameshift. The resulting isoform (c) is shorter and has a distinct C-terminus compared to isoform a. Variants 4 and 17-19 all encode the same isoform (c).
    Source sequence(s)
    AC008761, AK303623, AK316458, BC041130, BQ433639, DB158605
    Consensus CDS
    CCDS59366.1
    UniProtKB/TrEMBL
    B7ZAZ3
    Related
    ENSP00000472668.1, ENST00000595033.5
    Conserved Domains (3) summary
    PHA03247
    Location:203512
    PHA03247; large tegument protein UL36; Provisional
    cl10970
    Location:577838
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
    cl12013
    Location:1220
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  4. NM_001384370.1NP_001371299.1  F-BAR domain only protein 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 2. Variants 2, 3, and 5-16 all encode the same isoform (b).
    Source sequence(s)
    AC008761
    Consensus CDS
    CCDS32955.1
    UniProtKB/Swiss-Prot
    A6NHE6, A8K5U5, B4E120, O14526, Q05C93, Q8IW22
    UniProtKB/TrEMBL
    A0A8V8TPN1
    Related
    ENSP00000514204.1, ENST00000699207.1
    Conserved Domains (3) summary
    cd07674
    Location:10270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    PHA03247
    Location:253562
    PHA03247; large tegument protein UL36; Provisional
    cl10970
    Location:627888
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
  5. NM_001384371.1NP_001371300.1  F-BAR domain only protein 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 2. Variants 2, 3, and 5-16 all encode the same isoform (b).
    Source sequence(s)
    AC008761
    Consensus CDS
    CCDS32955.1
    UniProtKB/Swiss-Prot
    A6NHE6, A8K5U5, B4E120, O14526, Q05C93, Q8IW22
    UniProtKB/TrEMBL
    A0A8V8TPN1
    Related
    ENSP00000470511.2, ENST00000596309.6
    Conserved Domains (3) summary
    cd07674
    Location:10270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    PHA03247
    Location:253562
    PHA03247; large tegument protein UL36; Provisional
    cl10970
    Location:627888
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
  6. NM_001384372.1NP_001371301.1  F-BAR domain only protein 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 2. Variants 2, 3, and 5-16 all encode the same isoform (b).
    Source sequence(s)
    AC008761
    Consensus CDS
    CCDS32955.1
    UniProtKB/Swiss-Prot
    A6NHE6, A8K5U5, B4E120, O14526, Q05C93, Q8IW22
    UniProtKB/TrEMBL
    A0A8V8TPN1
    Related
    ENSP00000514180.1, ENST00000699177.1
    Conserved Domains (3) summary
    cd07674
    Location:10270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    PHA03247
    Location:253562
    PHA03247; large tegument protein UL36; Provisional
    cl10970
    Location:627888
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
  7. NM_001384373.1NP_001371302.1  F-BAR domain only protein 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 2. Variants 2, 3, and 5-16 all encode the same isoform (b).
    Source sequence(s)
    AC008761
    Consensus CDS
    CCDS32955.1
    UniProtKB/Swiss-Prot
    A6NHE6, A8K5U5, B4E120, O14526, Q05C93, Q8IW22
    UniProtKB/TrEMBL
    A0A8V8TPN1
    Conserved Domains (3) summary
    cd07674
    Location:10270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    PHA03247
    Location:253562
    PHA03247; large tegument protein UL36; Provisional
    cl10970
    Location:627888
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
  8. NM_001384374.1NP_001371303.1  F-BAR domain only protein 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 2. Variants 2, 3, and 5-16 all encode the same isoform (b).
    Source sequence(s)
    AC008761
    Consensus CDS
    CCDS32955.1
    UniProtKB/Swiss-Prot
    A6NHE6, A8K5U5, B4E120, O14526, Q05C93, Q8IW22
    UniProtKB/TrEMBL
    A0A8V8TPN1
    Related
    ENSP00000514179.1, ENST00000699176.1
    Conserved Domains (3) summary
    cd07674
    Location:10270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    PHA03247
    Location:253562
    PHA03247; large tegument protein UL36; Provisional
    cl10970
    Location:627888
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
  9. NM_001384375.1NP_001371304.1  F-BAR domain only protein 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 2. Variants 2, 3, and 5-16 all encode the same isoform (b).
    Source sequence(s)
    AC008761
    Consensus CDS
    CCDS32955.1
    UniProtKB/Swiss-Prot
    A6NHE6, A8K5U5, B4E120, O14526, Q05C93, Q8IW22
    UniProtKB/TrEMBL
    A0A8V8TPN1
    Conserved Domains (3) summary
    cd07674
    Location:10270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    PHA03247
    Location:253562
    PHA03247; large tegument protein UL36; Provisional
    cl10970
    Location:627888
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
  10. NM_001384376.1NP_001371305.1  F-BAR domain only protein 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR compared to variant 2. Variants 2, 3, and 5-16 all encode the same isoform (b).
    Source sequence(s)
    AC008761
    Consensus CDS
    CCDS32955.1
    UniProtKB/Swiss-Prot
    A6NHE6, A8K5U5, B4E120, O14526, Q05C93, Q8IW22
    UniProtKB/TrEMBL
    A0A8V8TPN1
    Related
    ENSP00000469075.2, ENST00000600209.6
    Conserved Domains (3) summary
    cd07674
    Location:10270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    PHA03247
    Location:253562
    PHA03247; large tegument protein UL36; Provisional
    cl10970
    Location:627888
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
  11. NM_001384377.1NP_001371306.1  F-BAR domain only protein 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) differs in the 5' UTR compared to variant 2. Variants 2, 3, and 5-16 all encode the same isoform (b).
    Source sequence(s)
    AC008761
    Consensus CDS
    CCDS32955.1
    UniProtKB/Swiss-Prot
    A6NHE6, A8K5U5, B4E120, O14526, Q05C93, Q8IW22
    UniProtKB/TrEMBL
    A0A8V8TPN1
    Conserved Domains (3) summary
    cd07674
    Location:10270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    PHA03247
    Location:253562
    PHA03247; large tegument protein UL36; Provisional
    cl10970
    Location:627888
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
  12. NM_001384378.1NP_001371307.1  F-BAR domain only protein 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13) differs in the 5' UTR compared to variant 2. Variants 2, 3, and 5-16 all encode the same isoform (b).
    Source sequence(s)
    AC008761
    Consensus CDS
    CCDS32955.1
    UniProtKB/Swiss-Prot
    A6NHE6, A8K5U5, B4E120, O14526, Q05C93, Q8IW22
    UniProtKB/TrEMBL
    A0A8V8TPN1
    Conserved Domains (3) summary
    cd07674
    Location:10270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    PHA03247
    Location:253562
    PHA03247; large tegument protein UL36; Provisional
    cl10970
    Location:627888
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
  13. NM_001384379.1NP_001371308.1  F-BAR domain only protein 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14) differs in the 5' UTR compared to variant 2. Variants 2, 3, and 5-16 all encode the same isoform (b).
    Source sequence(s)
    AC008761
    Consensus CDS
    CCDS32955.1
    UniProtKB/Swiss-Prot
    A6NHE6, A8K5U5, B4E120, O14526, Q05C93, Q8IW22
    UniProtKB/TrEMBL
    A0A8V8TPN1
    Conserved Domains (3) summary
    cd07674
    Location:10270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    PHA03247
    Location:253562
    PHA03247; large tegument protein UL36; Provisional
    cl10970
    Location:627888
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
  14. NM_001384380.1NP_001371309.1  F-BAR domain only protein 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15) differs in the 5' UTR compared to variant 2. Variants 2, 3, and 5-16 all encode the same isoform (b).
    Source sequence(s)
    AC008761
    Consensus CDS
    CCDS32955.1
    UniProtKB/Swiss-Prot
    A6NHE6, A8K5U5, B4E120, O14526, Q05C93, Q8IW22
    UniProtKB/TrEMBL
    A0A8V8TPN1
    Conserved Domains (3) summary
    cd07674
    Location:10270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    PHA03247
    Location:253562
    PHA03247; large tegument protein UL36; Provisional
    cl10970
    Location:627888
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
  15. NM_001384381.1NP_001371310.1  F-BAR domain only protein 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16) differs in the 5' UTR compared to variant 2. Variants 2, 3, and 5-16 all encode the same isoform (b).
    Source sequence(s)
    AC008761
    Consensus CDS
    CCDS32955.1
    UniProtKB/Swiss-Prot
    A6NHE6, A8K5U5, B4E120, O14526, Q05C93, Q8IW22
    UniProtKB/TrEMBL
    A0A8V8TPN1
    Conserved Domains (3) summary
    cd07674
    Location:10270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    PHA03247
    Location:253562
    PHA03247; large tegument protein UL36; Provisional
    cl10970
    Location:627888
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
  16. NM_001384384.1NP_001371313.1  F-BAR domain only protein 1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (17) differs in the 5' UTR compared to variant 4. Variants 4 and 17-19 all encode the same isoform (c).
    Source sequence(s)
    AC008761
    Consensus CDS
    CCDS59366.1
    UniProtKB/TrEMBL
    B7ZAZ3
    Conserved Domains (3) summary
    PHA03247
    Location:203512
    PHA03247; large tegument protein UL36; Provisional
    cl10970
    Location:577838
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
    cl12013
    Location:1220
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  17. NM_001384385.1NP_001371314.1  F-BAR domain only protein 1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (18) differs in the 5' UTR compared to variant 4. Variants 4 and 17-19 all encode the same isoform (c).
    Source sequence(s)
    AC008761
    Consensus CDS
    CCDS59366.1
    UniProtKB/TrEMBL
    B7ZAZ3
    Related
    ENST00000597512.1
    Conserved Domains (3) summary
    PHA03247
    Location:203512
    PHA03247; large tegument protein UL36; Provisional
    cl10970
    Location:577838
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
    cl12013
    Location:1220
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  18. NM_001384386.1NP_001371315.1  F-BAR domain only protein 1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (19) differs in the 5' UTR compared to variant 4. Variants 4 and 17-19 all encode the same isoform (c).
    Source sequence(s)
    AC008761
    Consensus CDS
    CCDS59366.1
    UniProtKB/TrEMBL
    B7ZAZ3
    Conserved Domains (3) summary
    PHA03247
    Location:203512
    PHA03247; large tegument protein UL36; Provisional
    cl10970
    Location:577838
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
    cl12013
    Location:1220
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  19. NM_001384387.1NP_001371316.1  F-BAR domain only protein 1 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC008761
    UniProtKB/TrEMBL
    A0A8V8TPN1
    Conserved Domains (3) summary
    cd07674
    Location:10270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    PHA03247
    Location:253562
    PHA03247; large tegument protein UL36; Provisional
    cl10970
    Location:627881
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
  20. NM_001384388.1NP_001371317.1  F-BAR domain only protein 1 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (21) differs in the 5' UTR compared to variant 22. Variants 21 and 22 both encode the same isoform (e).
    Source sequence(s)
    AC008761
    Consensus CDS
    CCDS92560.1
    UniProtKB/TrEMBL
    A0A8V8TMX9, A0A8V8TPN1
    Related
    ENSP00000514200.1, ENST00000699202.1
    Conserved Domains (3) summary
    PHA03247
    Location:240549
    PHA03247; large tegument protein UL36; Provisional
    cl10970
    Location:614875
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
    cl12013
    Location:10257
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  21. NM_001384389.1NP_001371318.1  F-BAR domain only protein 1 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (22) differs in the 5' UTR compared to variant 21. Variants 21 and 22 both encode the same isoform (e).
    Source sequence(s)
    AC008761
    Consensus CDS
    CCDS92560.1
    UniProtKB/TrEMBL
    A0A8V8TMX9, A0A8V8TPN1
    Conserved Domains (3) summary
    PHA03247
    Location:240549
    PHA03247; large tegument protein UL36; Provisional
    cl10970
    Location:614875
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
    cl12013
    Location:10257
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  22. NM_001384390.1NP_001371319.1  F-BAR domain only protein 1 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC008761
    UniProtKB/TrEMBL
    B7ZAZ3
    Conserved Domains (3) summary
    PHA03247
    Location:228537
    PHA03247; large tegument protein UL36; Provisional
    cl10970
    Location:602863
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
    cl12013
    Location:10245
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  23. NM_001384391.1NP_001371320.1  F-BAR domain only protein 1 isoform g

    Status: VALIDATED

    Source sequence(s)
    AC008761
    UniProtKB/TrEMBL
    A0A8V8TP91
    Conserved Domains (3) summary
    cd07674
    Location:10270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    PHA03247
    Location:253562
    PHA03247; large tegument protein UL36; Provisional
    cl10970
    Location:627759
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
  24. NM_001384392.1NP_001371321.1  F-BAR domain only protein 1 isoform h

    Status: VALIDATED

    Source sequence(s)
    AC008761
    UniProtKB/TrEMBL
    A0A8V8TPN1
    Conserved Domains (3) summary
    cd07674
    Location:10270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    PHA03247
    Location:253533
    PHA03247; large tegument protein UL36; Provisional
    cl10970
    Location:588843
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
  25. NM_001384393.1NP_001371322.1  F-BAR domain only protein 1 isoform i

    Status: VALIDATED

    Description
    Transcript Variant: This variant (26) encodes isoform i. Variants 26-28 all encode the same isoform (i).
    Source sequence(s)
    AC008761
    Consensus CDS
    CCDS92558.1
    UniProtKB/TrEMBL
    A0A8V8TPN1, M0QYA9
    Related
    ENSP00000514196.1, ENST00000699198.1
    Conserved Domains (3) summary
    cd07674
    Location:10270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    PHA03247
    Location:253533
    PHA03247; large tegument protein UL36; Provisional
    cd09268
    Location:588849
    FCHo1_MHD; mu-homology domain (MHD) of F-BAR domain-containing Fer/Cip4 homology domain-only protein 1 (FCH domain only 1 or FCHo1, also known as KIAA0290) and similar proteins
  26. NM_001384394.1NP_001371323.1  F-BAR domain only protein 1 isoform i

    Status: VALIDATED

    Description
    Transcript Variant: This variant (27) differs in the 5' UTR compared to variant 26. Variants 26-28 all encode the same isoform (i).
    Source sequence(s)
    AC008761
    Consensus CDS
    CCDS92558.1
    UniProtKB/TrEMBL
    A0A8V8TPN1, M0QYA9
    Conserved Domains (3) summary
    cd07674
    Location:10270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    PHA03247
    Location:253533
    PHA03247; large tegument protein UL36; Provisional
    cd09268
    Location:588849
    FCHo1_MHD; mu-homology domain (MHD) of F-BAR domain-containing Fer/Cip4 homology domain-only protein 1 (FCH domain only 1 or FCHo1, also known as KIAA0290) and similar proteins
  27. NM_001384395.1NP_001371324.1  F-BAR domain only protein 1 isoform i

    Status: VALIDATED

    Description
    Transcript Variant: This variant (28) differs in the 5' UTR compared to variant 26. Variants 26-28 all encode the same isoform (i).
    Source sequence(s)
    AC008761
    Consensus CDS
    CCDS92558.1
    UniProtKB/TrEMBL
    A0A8V8TPN1, M0QYA9
    Related
    ENSP00000514209.1, ENST00000699213.1
    Conserved Domains (3) summary
    cd07674
    Location:10270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    PHA03247
    Location:253533
    PHA03247; large tegument protein UL36; Provisional
    cd09268
    Location:588849
    FCHo1_MHD; mu-homology domain (MHD) of F-BAR domain-containing Fer/Cip4 homology domain-only protein 1 (FCH domain only 1 or FCHo1, also known as KIAA0290) and similar proteins
  28. NM_001384396.1NP_001371325.1  F-BAR domain only protein 1 isoform j

    Status: VALIDATED

    Description
    Transcript Variant: This variant (29) encodes isoform j. Variants 29-35 all encode the same isoform (j).
    Source sequence(s)
    AC008761
    Consensus CDS
    CCDS92559.1
    UniProtKB/TrEMBL
    A0A8V8TNC3, A0A8V8TPN1
    Conserved Domains (2) summary
    cd07674
    Location:10270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    cd09268
    Location:535796
    FCHo1_MHD; mu-homology domain (MHD) of F-BAR domain-containing Fer/Cip4 homology domain-only protein 1 (FCH domain only 1 or FCHo1, also known as KIAA0290) and similar proteins
  29. NM_001384397.1NP_001371326.1  F-BAR domain only protein 1 isoform j

    Status: VALIDATED

    Description
    Transcript Variant: This variant (30) differs in the 5' UTR compared to variant 29. Variants 29-35 all encode the same isoform (j).
    Source sequence(s)
    AC008761
    Consensus CDS
    CCDS92559.1
    UniProtKB/TrEMBL
    A0A8V8TNC3, A0A8V8TPN1
    Conserved Domains (2) summary
    cd07674
    Location:10270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    cd09268
    Location:535796
    FCHo1_MHD; mu-homology domain (MHD) of F-BAR domain-containing Fer/Cip4 homology domain-only protein 1 (FCH domain only 1 or FCHo1, also known as KIAA0290) and similar proteins
  30. NM_001384398.1NP_001371327.1  F-BAR domain only protein 1 isoform j

    Status: VALIDATED

    Description
    Transcript Variant: This variant (31) differs in the 5' UTR compared to variant 29. Variants 29-35 all encode the same isoform (j).
    Source sequence(s)
    AC008761
    Consensus CDS
    CCDS92559.1
    UniProtKB/TrEMBL
    A0A8V8TNC3, A0A8V8TPN1
    Related
    ENSP00000514198.1, ENST00000699200.1
    Conserved Domains (2) summary
    cd07674
    Location:10270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    cd09268
    Location:535796
    FCHo1_MHD; mu-homology domain (MHD) of F-BAR domain-containing Fer/Cip4 homology domain-only protein 1 (FCH domain only 1 or FCHo1, also known as KIAA0290) and similar proteins
  31. NM_001384399.1NP_001371328.1  F-BAR domain only protein 1 isoform j

    Status: VALIDATED

    Description
    Transcript Variant: This variant (32) differs in the 5' UTR compared to variant 29. Variants 29-35 all encode the same isoform (j).
    Source sequence(s)
    AC008761
    Consensus CDS
    CCDS92559.1
    UniProtKB/TrEMBL
    A0A8V8TNC3, A0A8V8TPN1
    Related
    ENSP00000514195.1, ENST00000699197.1
    Conserved Domains (2) summary
    cd07674
    Location:10270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    cd09268
    Location:535796
    FCHo1_MHD; mu-homology domain (MHD) of F-BAR domain-containing Fer/Cip4 homology domain-only protein 1 (FCH domain only 1 or FCHo1, also known as KIAA0290) and similar proteins
  32. NM_001384400.1NP_001371329.1  F-BAR domain only protein 1 isoform j

    Status: VALIDATED

    Description
    Transcript Variant: This variant (33) differs in the 5' UTR compared to variant 29. Variants 29-35 all encode the same isoform (j).
    Source sequence(s)
    AC008761
    Consensus CDS
    CCDS92559.1
    UniProtKB/TrEMBL
    A0A8V8TNC3, A0A8V8TPN1
    Conserved Domains (2) summary
    cd07674
    Location:10270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    cd09268
    Location:535796
    FCHo1_MHD; mu-homology domain (MHD) of F-BAR domain-containing Fer/Cip4 homology domain-only protein 1 (FCH domain only 1 or FCHo1, also known as KIAA0290) and similar proteins
  33. NM_001384401.1NP_001371330.1  F-BAR domain only protein 1 isoform j

    Status: VALIDATED

    Description
    Transcript Variant: This variant (34) differs in the 5' UTR compared to variant 29. Variants 29-35 all encode the same isoform (j).
    Source sequence(s)
    AC008761
    Consensus CDS
    CCDS92559.1
    UniProtKB/TrEMBL
    A0A8V8TNC3, A0A8V8TPN1
    Conserved Domains (2) summary
    cd07674
    Location:10270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    cd09268
    Location:535796
    FCHo1_MHD; mu-homology domain (MHD) of F-BAR domain-containing Fer/Cip4 homology domain-only protein 1 (FCH domain only 1 or FCHo1, also known as KIAA0290) and similar proteins
  34. NM_001384402.1NP_001371331.1  F-BAR domain only protein 1 isoform j

    Status: VALIDATED

    Description
    Transcript Variant: This variant (35) differs in the 5' UTR compared to variant 29. Variants 29-35 all encode the same isoform (j).
    Source sequence(s)
    AC008761
    Consensus CDS
    CCDS92559.1
    UniProtKB/TrEMBL
    A0A8V8TNC3, A0A8V8TPN1
    Related
    ENSP00000514212.1, ENST00000699216.1
    Conserved Domains (2) summary
    cd07674
    Location:10270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    cd09268
    Location:535796
    FCHo1_MHD; mu-homology domain (MHD) of F-BAR domain-containing Fer/Cip4 homology domain-only protein 1 (FCH domain only 1 or FCHo1, also known as KIAA0290) and similar proteins
  35. NM_001384403.1NP_001371332.1  F-BAR domain only protein 1 isoform k

    Status: VALIDATED

    Source sequence(s)
    AC008761
    UniProtKB/TrEMBL
    A0A8V8TPA0
    Conserved Domains (2) summary
    cd07674
    Location:10263
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    cd09268
    Location:520781
    FCHo1_MHD; mu-homology domain (MHD) of F-BAR domain-containing Fer/Cip4 homology domain-only protein 1 (FCH domain only 1 or FCHo1, also known as KIAA0290) and similar proteins
  36. NM_001384404.1NP_001371333.1  F-BAR domain only protein 1 isoform l

    Status: VALIDATED

    Source sequence(s)
    AC008761
    Conserved Domains (2) summary
    cd07674
    Location:10270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    cl10970
    Location:535667
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
  37. NM_001384405.1NP_001371334.1  F-BAR domain only protein 1 isoform m

    Status: VALIDATED

    Source sequence(s)
    AC008761
    UniProtKB/TrEMBL
    A0A8V8TP91
    Related
    ENSP00000514194.1, ENST00000699196.1
    Conserved Domains (3) summary
    PHA03247
    Location:240549
    PHA03247; large tegument protein UL36; Provisional
    cl10970
    Location:614764
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
    cl12013
    Location:10257
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  38. NM_001384406.1NP_001371335.1  F-BAR domain only protein 1 isoform n

    Status: VALIDATED

    Source sequence(s)
    AC008761
    Conserved Domains (2) summary
    cl10970
    Location:485617
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
    cl12013
    Location:1220
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  39. NM_001384407.1NP_001371336.1  F-BAR domain only protein 1 isoform o

    Status: VALIDATED

    Source sequence(s)
    AC008761
    Consensus CDS
    CCDS92561.1
    UniProtKB/TrEMBL
    A0A8V8TPM7
    Related
    ENSP00000514201.1, ENST00000699203.1
    Conserved Domains (2) summary
    cl10970
    Location:437587
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
    cl12013
    Location:1220
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  40. NM_015122.3NP_055937.1  F-BAR domain only protein 1 isoform b

    See identical proteins and their annotated locations for NP_055937.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate splice site in the 3' coding region compared to variant 1, that results in a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 2, 3, and 5-16 all encode the same isoform (b).
    Source sequence(s)
    AC008761, AK303623, BC041130, BQ433639, DB158605
    Consensus CDS
    CCDS32955.1
    UniProtKB/Swiss-Prot
    A6NHE6, A8K5U5, B4E120, O14526, Q05C93, Q8IW22
    UniProtKB/TrEMBL
    A0A8V8TPN1
    Related
    ENSP00000470731.1, ENST00000596536.6
    Conserved Domains (3) summary
    cd07674
    Location:10270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    PHA03247
    Location:253562
    PHA03247; large tegument protein UL36; Provisional
    cl10970
    Location:627888
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)

RNA

  1. NR_169219.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008761
  2. NR_169220.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008761
    Related
    ENST00000699205.1
  3. NR_169221.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008761
    Related
    ENST00000699201.1
  4. NR_169222.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008761
  5. NR_169223.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008761
  6. NR_169224.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008761
  7. NR_169225.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008761
  8. NR_169226.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008761
  9. NR_169227.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008761
  10. NR_169228.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008761
  11. NR_169229.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008761
  12. NR_169230.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008761
  13. NR_169231.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008761
  14. NR_169232.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008761
  15. NR_169233.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008761
  16. NR_169234.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008761
  17. NR_169235.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008761
  18. NR_169236.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008761
  19. NR_169238.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008761
  20. NR_169239.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008761
    Related
    ENST00000699206.1
  21. NR_169240.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008761
  22. NR_169246.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008761
  23. NR_169247.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008761
  24. NR_169248.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008761
  25. NR_169249.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008761
  26. NR_169250.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008761
  27. NR_169251.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008761
  28. NR_169252.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008761
    Related
    ENST00000699210.1
  29. NR_169253.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008761
  30. NR_169254.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008761
  31. NR_169255.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008761
  32. NR_169256.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008761
  33. NR_169257.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008761
  34. NR_169258.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008761
  35. NR_169259.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008761
  36. NR_169260.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008761

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    17747744..17788561
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438491.1XP_047294447.1  F-BAR domain only protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8V8TPN1, M0QYA9
    Related
    ENSP00000514197.1, ENST00000699199.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    17881862..17922647
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320312.1XP_054176287.1  F-BAR domain only protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8V8TPN1, M0QYA9