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Fcho1 FCH domain only 1 [ Mus musculus (house mouse) ]

Gene ID: 74015, updated on 26-Sep-2022

Summary

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Official Symbol
Fcho1provided by MGI
Official Full Name
FCH domain only 1provided by MGI
Primary source
MGI:MGI:1921265
See related
Ensembl:ENSMUSG00000070000 AllianceGenome:MGI:1921265
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
3322402E17Rik
Summary
Predicted to enable AP-2 adaptor complex binding activity. Predicted to be involved in clathrin coat assembly and clathrin-dependent endocytosis. Predicted to act upstream of or within endocytosis. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in clathrin-coated pit and clathrin-coated vesicle. Is expressed in central nervous system; ganglia; neural retina; and thymus primordium. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human FCHO1 (FCH and mu domain containing endocytic adaptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 111.2), spleen adult (RPKM 53.6) and 13 other tissues See more
Orthologs
human all
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Genomic context

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See Fcho1 in Genome Data Viewer
Location:
8; 8 B3.3
Exon count:
30
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (72161031..72181980, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (71708387..71729330, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 Neighboring gene predicted gene 45756 Neighboring gene CCR4-NOT transcription complex, subunit 8 pseudogene Neighboring gene predicted gene, 35572 Neighboring gene proteinase-activated receptor 4-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. NECAP 1 regulates AP-2 interactions to control vesicle size, number, and cargo during clathrin-mediated endocytosis. Ritter B, et al. PLoS Biol, 2013 Oct. PMID 24130457, Free PMC Article
  2. Genetic and structural analysis of the basolateral amygdala complex in BXD recombinant inbred mice. Mozhui K, et al. Behav Genet, 2007 Jan. PMID 17131200
  3. Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning. Umasankar PK, et al. Nat Cell Biol, 2012 Apr 8. PMID 22484487, Free PMC Article
  4. High-throughput mapping of a dynamic signaling network in mammalian cells. Barrios-Rodiles M, et al. Science, 2005 Mar 11. PMID 15761153
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895

See all (18) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0290

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables AP-2 adaptor complex binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in clathrin coat assembly IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in clathrin coat assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in clathrin-dependent endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in clathrin-dependent endocytosis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of T cell activation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in clathrin-coated pit IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in clathrin-coated pit ISO
Inferred from Sequence Orthology
more info
  
is_active_in clathrin-coated vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
F-BAR domain only protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028715.3 → NP_082991.3  F-BAR domain only protein 1

    See identical proteins and their annotated locations for NP_082991.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes the functional protein.
    Source sequence(s)
    AK137333, BU614854, BY274600, BY601220
    Consensus CDS
    CCDS52588.1
    UniProtKB/Swiss-Prot
    D3Z3Q5, Q8K285
    Related
    ENSMUSP00000091151.7, ENSMUST00000093444.13
    Conserved Domains (2) summary
    cd07674
    Location:10 → 270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    cl10970
    Location:611 → 872
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)

RNA

  1. NR_028267.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate, internal segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK014382, AK137333, BU614854, BY274600, BY601220
    Related
    ENSMUST00000143699.8

  2. NR_131256.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA014311, AK014382, AK137333, BY274600, BY601220
    Related
    ENSMUST00000136640.8

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    72161031..72181980 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243805.2 → XP_030099665.1  F-BAR domain only protein 1 isoform X1

    UniProtKB/Swiss-Prot
    D3Z3Q5
    Conserved Domains (2) summary
    cd07674
    Location:10 → 270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    cl10970
    Location:611 → 872
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)

  2. XM_011242331.3 → XP_011240633.1  F-BAR domain only protein 1 isoform X3

    Conserved Domains (2) summary
    cd07674
    Location:10 → 270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    cl10970
    Location:611 → 820
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)

  3. XM_006509766.4 → XP_006509829.1  F-BAR domain only protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006509829.1

    UniProtKB/Swiss-Prot
    D3Z3Q5, Q8K285
    Conserved Domains (2) summary
    cd07674
    Location:10 → 270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    cl10970
    Location:611 → 872
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)

  4. XM_030243806.1 → XP_030099666.1  F-BAR domain only protein 1 isoform X4

    Conserved Domains (1) summary
    cl10970
    Location:385 → 646
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)

  5. XM_006509767.4 → XP_006509830.1  F-BAR domain only protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006509830.1

    UniProtKB/Swiss-Prot
    D3Z3Q5, Q8K285
    Conserved Domains (2) summary
    cd07674
    Location:10 → 270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    cl10970
    Location:611 → 872
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)

  6. XM_006509765.3 → XP_006509828.1  F-BAR domain only protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006509828.1

    UniProtKB/Swiss-Prot
    D3Z3Q5, Q8K285
    Conserved Domains (2) summary
    cd07674
    Location:10 → 270
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    cl10970
    Location:611 → 872
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)

  7. XM_006509770.5 → XP_006509833.1  F-BAR domain only protein 1 isoform X5

    Conserved Domains (1) summary
    cl10970
    Location:344 → 605
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)

  8. XM_036154324.1 → XP_036010217.1  F-BAR domain only protein 1 isoform X2

    Conserved Domains (2) summary
    cd07674
    Location:2 → 262
    F-BAR_FCHO1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 1 protein
    cl10970
    Location:603 → 864
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)

RNA

  1. XR_870464.3 RNA Sequence

  2. XR_001778482.2 RNA Sequence

  3. XR_003947348.1 RNA Sequence

  4. XR_003947347.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K285.2 GenPept UniProtKB/Swiss-Prot:Q8K285

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