Paqr3 progestin and adipoQ receptor family member III [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Paqr3provided by MGI
Official Full Name: progestin and adipoQ receptor family member IIIprovided by MGI
Primary source: MGI:MGI:2679683
See related: Ensembl:ENSMUSG00000055725 AllianceGenome:MGI:2679683
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RKTG; 6330415A20Rik
Summary: Predicted to enable signaling receptor activity. Acts upstream of or within negative regulation of MAP kinase activity. Predicted to be located in Golgi apparatus. Orthologous to human PAQR3 (progestin and adipoQ receptor family member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 5.7), whole brain E14.5 (RPKM 5.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5; 5 E3

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (97229223..97259608, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (97081364..97111749, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PAQR3 depletion accelerates diabetic wound healing by promoting angiogenesis through inhibiting STUB1-mediated PPARgamma degradation.
Title: PAQR3 depletion accelerates diabetic wound healing by promoting angiogenesis through inhibiting STUB1-mediated PPARγ degradation.
Silencing PAQR3 protects against oxygen-glucose deprivation/reperfusion-induced neuronal apoptosis via activation of PI3K/AKT signaling in PC12 cells.
Title: Silencing PAQR3 protects against oxygen-glucose deprivation/reperfusion-induced neuronal apoptosis via activation of PI3K/AKT signaling in PC12 cells.
PAQR3 plays a pivotal role in controlling hepatic LDLR degradation and blood LDL-C level via modulating LDLR-PCSK9 interaction.
Title: PAQR3 modulates blood cholesterol level by facilitating interaction between LDLR and PCSK9.
PAQR3 controls autophagy by integrating AMPK signaling to enhance ATG14L-associated PI3K activity
Title: PAQR3 controls autophagy by integrating AMPK signaling to enhance ATG14L-associated PI3K activity.
PAQR3 regulates cholesterol homeostasis by anchoring Scap/SREBP to the Golgi and disruption of such function reduces cholesterol biosynthesis.
Title: PAQR3 modulates cholesterol homeostasis by anchoring Scap/SREBP complex to the Golgi apparatus.
This study reveals that PAQR3 has an important physiological function in modulating obesity, energy metabolism, and leptin signaling.
Title: PAQR3 has modulatory roles in obesity, energy metabolism, and leptin signaling.
PAQR3 negatively regulates insulin signaling by shunting cytosolic p110alpha to the Golgi apparatus while competing with p85 subunit in forming a PI3K complex with p110alpha.
Title: PAQR3 modulates insulin signaling by shunting phosphoinositide 3-kinase p110α to the Golgi apparatus.
Loss of PAQR3 is associated with tumorigenesis of colorectal cancers.
Title: PAQR3 plays a suppressive role in the tumorigenesis of colorectal cancers.
reveal a paradigm of spatial regulation of Raf kinase by RKTG via sequestrating Raf-1 to the Golgi apparatus and thereby inhibiting the ERK signaling pathway.
Title: Spatial regulation of Raf kinase signaling by RKTG.
RKTG has a suppressive activity in chemical carcinogen-induced mitogenesis and tumor formation in mouse skin.
Title: Suppressive function of RKTG on chemical carcinogen-induced skin carcinogenesis in mouse.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:224804

Bmp2k (e-PCR), detects polymorphism
- UniSTS:498223

NoName (e-PCR)
- UniSTS:495310

BB424054 (e-PCR)
- UniSTS:207829

NoName (e-PCR)
- UniSTS:235230

Homology

Homologs of the Paqr3 gene: The Paqr3 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, and frog.
Orthologs from Annotation Pipeline: 476 organisms have orthologs with human gene Paqr3
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of MAP kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within negative regulation of neuron projection development	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within negative regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within negative regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within protein localization to Golgi apparatus	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: progestin and adipoQ receptor family member 3

Names: Raf kinase trapping to Golgi

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001359910.1 → NP_001346839.1 progestin and adipoQ receptor family member 3 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).

Source sequence(s)

AC125229, AK149213

Consensus CDS

CCDS19451.1

UniProtKB/Swiss-Prot

Q6TCG8

UniProtKB/TrEMBL

A0A6P5PVK1, A0A8C6HNL4, Q0VAZ2

Related

ENSMUSP00000108593.4, ENSMUST00000112969.10

Conserved Domains (1) summary

pfam03006
Location:64 → 283

HlyIII; Haemolysin-III related
NM_001359913.1 → NP_001346842.1 progestin and adipoQ receptor family member 3 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.

Source sequence(s)

AC125229

Consensus CDS

CCDS89954.1

UniProtKB/TrEMBL

D3Z181

Related

ENSMUSP00000108592.2, ENSMUST00000112968.2

Conserved Domains (1) summary

cl03831
Location:64 → 170

HlyIII; Haemolysin-III related
NM_198422.3 → NP_940814.1 progestin and adipoQ receptor family member 3 isoform a

See identical proteins and their annotated locations for NP_940814.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).

Source sequence(s)

AC125229

Consensus CDS

CCDS19451.1

UniProtKB/Swiss-Prot

Q6TCG8

UniProtKB/TrEMBL

A0A6P5PVK1, A0A8C6HNL4, Q0VAZ2

Related

ENSMUSP00000069324.3, ENSMUST00000069453.9

Conserved Domains (1) summary

pfam03006
Location:64 → 283

HlyIII; Haemolysin-III related

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

97229223..97259608 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036165068.1 → XP_036020961.1 progestin and adipoQ receptor family member 3 isoform X3

Conserved Domains (1) summary

cl03831
Location:64 → 217

HlyIII; Haemolysin-III related
XM_006534876.4 → XP_006534939.1 progestin and adipoQ receptor family member 3 isoform X2

Conserved Domains (1) summary

cl03831
Location:64 → 262

HlyIII; Haemolysin-III related
XM_006534875.5 → XP_006534938.1 progestin and adipoQ receptor family member 3 isoform X1

See identical proteins and their annotated locations for XP_006534938.1

UniProtKB/Swiss-Prot

Q6TCG8

UniProtKB/TrEMBL

A0A6P5PVK1, A0A8C6HNL4, Q0VAZ2

Conserved Domains (1) summary

pfam03006
Location:64 → 283

HlyIII; Haemolysin-III related
XM_036165067.1 → XP_036020960.1 progestin and adipoQ receptor family member 3 isoform X2

Conserved Domains (1) summary

cl03831
Location:64 → 262

HlyIII; Haemolysin-III related