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PAQR3 progestin and adipoQ receptor family member 3 [ Homo sapiens (human) ]

Gene ID: 152559, updated on 2-Aug-2021

Summary

Official Symbol
PAQR3provided by HGNC
Official Full Name
progestin and adipoQ receptor family member 3provided by HGNC
Primary source
HGNC:HGNC:30130
See related
Ensembl:ENSG00000163291 MIM:614577
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RKTG
Summary
This gene encodes a seven-transmembrane protein localized in the Golgi apparatus in mammalian cells. The encoded protein belongs to the progestin and adipoQ receptor (PAQR) family. This protein functions as a tumor suppressor by inhibiting the Raf/MEK/ERK signaling cascade. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]
Expression
Broad expression in testis (RPKM 20.7), brain (RPKM 8.5) and 24 other tissues See more
Orthologs
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Genomic context

See PAQR3 in Genome Data Viewer
Location:
4q21.21
Exon count:
15
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (78887225..78939438, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (79833032..79860592, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377299 Neighboring gene BMP2 inducible kinase Neighboring gene Sharpr-MPRA regulatory region 10702 Neighboring gene RNA, 7SL, cytoplasmic 127, pseudogene Neighboring gene long intergenic non-protein coding RNA 1088 Neighboring gene N-alpha-acetyltransferase 11, NatA catalytic subunit Neighboring gene uncharacterized LOC105377300

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

General protein information

Preferred Names
progestin and adipoQ receptor family member 3
Names
Raf kinase trapping to Golgi
progestin and adipoQ receptor family member III

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053104.1 RefSeqGene

    Range
    5001..32561
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001040202.2NP_001035292.1  progestin and adipoQ receptor family member 3 isoform 1

    See identical proteins and their annotated locations for NP_001035292.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC093841, AY424281, BX648346, DA410845
    Consensus CDS
    CCDS34020.1
    UniProtKB/Swiss-Prot
    Q6TCH7
    Related
    ENSP00000421981.1, ENST00000512733.5
    Conserved Domains (1) summary
    pfam03006
    Location:64283
    HlyIII; Haemolysin-III related
  2. NM_001350105.2NP_001337034.1  progestin and adipoQ receptor family member 3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1. Both variants 2 and 3 encode the same protein.
    Source sequence(s)
    AC093841
    Conserved Domains (1) summary
    cl03831
    Location:1165
    HlyIII; Haemolysin-III related
  3. NM_001350106.2NP_001337035.1  progestin and adipoQ receptor family member 3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1. Both variants 2 and 3 encode the same protein.
    Source sequence(s)
    AC093841
    Conserved Domains (1) summary
    cl03831
    Location:1165
    HlyIII; Haemolysin-III related

RNA

  1. NR_146462.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC093841
  2. NR_146463.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC093841
  3. NR_146464.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC093841
  4. NR_146465.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) uses an alternate 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC093841

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    78887225..78939438 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005262769.5XP_005262826.1  progestin and adipoQ receptor family member 3 isoform X2

    See identical proteins and their annotated locations for XP_005262826.1

    Related
    ENSP00000344203.6, ENST00000342820.10
    Conserved Domains (1) summary
    cl03831
    Location:64264
    HlyIII; Haemolysin-III related
  2. XM_024453909.1XP_024309677.1  progestin and adipoQ receptor family member 3 isoform X1

    Related
    ENSP00000425080.1, ENST00000511594.5
    Conserved Domains (1) summary
    pfam03006
    Location:64283
    HlyIII; Haemolysin-III related
  3. XM_024453910.1XP_024309678.1  progestin and adipoQ receptor family member 3 isoform X3

    Conserved Domains (1) summary
    cl03831
    Location:1165
    HlyIII; Haemolysin-III related

RNA

  1. XR_938694.3 RNA Sequence

  2. XR_002959712.1 RNA Sequence

  3. XR_001741146.2 RNA Sequence

  4. XR_002959711.1 RNA Sequence

  5. XR_002959713.1 RNA Sequence

  6. XR_002959714.1 RNA Sequence

    Related
    ENST00000515853.5

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177453.2: Suppressed sequence

    Description
    NM_177453.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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