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ZBTB43 zinc finger and BTB domain containing 43 [ Homo sapiens (human) ]

Gene ID: 23099, updated on 25-Nov-2021

Summary

Official Symbol
ZBTB43provided by HGNC
Official Full Name
zinc finger and BTB domain containing 43provided by HGNC
Primary source
HGNC:HGNC:17908
See related
Ensembl:ENSG00000169155 MIM:618676
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF-X; ZBTB22B; ZNF297B
Expression
Broad expression in bone marrow (RPKM 18.2), testis (RPKM 10.2) and 24 other tissues See more
Orthologs
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Genomic context

See ZBTB43 in Genome Data Viewer
Location:
9q33.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (126804072..126838210)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (129567319..129600489)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 3640 Neighboring gene uncharacterized LOC107987129 Neighboring gene zinc finger and BTB domain containing 34 Neighboring gene Ral GEF with PH domain and SH3 binding motif 1 Neighboring gene uncharacterized LOC105376279

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger and BTB domain-containing protein 43
Names
zinc finger and BTB domain-containing protein 22B
zinc finger protein 297B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135776.2NP_001129248.1  zinc finger and BTB domain-containing protein 43

    See identical proteins and their annotated locations for NP_001129248.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
    Source sequence(s)
    AL161731, AL354944, DA500531
    Consensus CDS
    CCDS6867.1
    UniProtKB/Swiss-Prot
    O43298
    Related
    ENSP00000390344.1, ENST00000449886.5
    Conserved Domains (3) summary
    sd00017
    Location:376394
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18227
    Location:8128
    BTB_POZ_ZBTB43; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43)
    pfam13465
    Location:414437
    zf-H2C2_2; Zinc-finger double domain
  2. NM_014007.4NP_054726.1  zinc finger and BTB domain-containing protein 43

    See identical proteins and their annotated locations for NP_054726.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
    Source sequence(s)
    AL161731, AL354944, BC008828, DA864775
    Consensus CDS
    CCDS6867.1
    UniProtKB/Swiss-Prot
    O43298
    Related
    ENSP00000362563.4, ENST00000373464.5
    Conserved Domains (3) summary
    sd00017
    Location:376394
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18227
    Location:8128
    BTB_POZ_ZBTB43; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43)
    pfam13465
    Location:414437
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    126804072..126838210
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518409.1XP_011516711.1  zinc finger and BTB domain-containing protein 43 isoform X1

    See identical proteins and their annotated locations for XP_011516711.1

    UniProtKB/Swiss-Prot
    O43298
    Conserved Domains (3) summary
    sd00017
    Location:376394
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18227
    Location:8128
    BTB_POZ_ZBTB43; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43)
    pfam13465
    Location:414437
    zf-H2C2_2; Zinc-finger double domain
  2. XM_005251835.3XP_005251892.1  zinc finger and BTB domain-containing protein 43 isoform X1

    See identical proteins and their annotated locations for XP_005251892.1

    UniProtKB/Swiss-Prot
    O43298
    Conserved Domains (3) summary
    sd00017
    Location:376394
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18227
    Location:8128
    BTB_POZ_ZBTB43; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43)
    pfam13465
    Location:414437
    zf-H2C2_2; Zinc-finger double domain
  3. XM_011518411.2XP_011516713.1  zinc finger and BTB domain-containing protein 43 isoform X1

    See identical proteins and their annotated locations for XP_011516713.1

    UniProtKB/Swiss-Prot
    O43298
    Conserved Domains (3) summary
    sd00017
    Location:376394
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18227
    Location:8128
    BTB_POZ_ZBTB43; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43)
    pfam13465
    Location:414437
    zf-H2C2_2; Zinc-finger double domain
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