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TRIM35 tripartite motif containing 35 [ Homo sapiens (human) ]

Gene ID: 23087, updated on 10-Jul-2021

Summary

Official Symbol
TRIM35provided by HGNC
Official Full Name
tripartite motif containing 35provided by HGNC
Primary source
HGNC:HGNC:16285
See related
Ensembl:ENSG00000104228 MIM:617007
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HLS5; MAIR
Summary
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The function of this protein has not been identified. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in skin (RPKM 5.7), testis (RPKM 5.1) and 25 other tissues See more
Orthologs
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Genomic context

See TRIM35 in Genome Data Viewer
Location:
8p21.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (27284886..27311272, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (27142403..27168789, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379340 Neighboring gene stathmin 4 Neighboring gene protein tyrosine kinase 2 beta Neighboring gene Sharpr-MPRA regulatory region 13363 Neighboring gene microRNA 6842

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-treated vaginal epithelial cells show downregulation of tripartite motif containing 35 (TRIM35) expression as compared to untreated control PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1098, MGC17233

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in innate immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of viral release from host cell IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase TRIM35
Names
hemopoietic lineage switch protein 5
tripartite motif-containing protein 35
NP_001291424.1
NP_001349742.1
NP_741983.2
XP_011542755.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304495.2NP_001291424.1  E3 ubiquitin-protein ligase TRIM35 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two exons in the central coding region one of which results in a frameshift compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC124649, AK308236, BU622420
    Consensus CDS
    CCDS78322.1
    UniProtKB/TrEMBL
    E5RGB3
    Related
    ENSP00000428770.1, ENST00000521253.1
    Conserved Domains (2) summary
    cd00021
    Location:99137
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cl17238
    Location:1862
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  2. NM_001362813.2NP_001349742.1  E3 ubiquitin-protein ligase TRIM35 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the central coding region, resulting in a frameshift compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC124649, AF492463, BU622420
    Conserved Domains (4) summary
    COG1322
    Location:133246
    RmuC; DNA anti-recombination protein (rearrangement mutator) RmuC [Replication, recombination and repair]
    cd00162
    Location:2160
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cl00034
    Location:96139
    Bbox_SF; B-box-type zinc finger superfamily
    cl17238
    Location:1862
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  3. NM_171982.5NP_741983.2  E3 ubiquitin-protein ligase TRIM35 isoform 1

    See identical proteins and their annotated locations for NP_741983.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC124649, AF492463, BU622420
    Consensus CDS
    CCDS6056.2
    UniProtKB/Swiss-Prot
    Q9UPQ4
    Related
    ENSP00000301924.4, ENST00000305364.9
    Conserved Domains (4) summary
    cd12893
    Location:303482
    SPRY_PRY_TRIM35; PRY/SPRY domain in tripartite motif-containing protein 35 (TRIM35)
    cd16599
    Location:1862
    RING-HC_TRIM35_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 35 (TRIM35) and similar proteins
    pfam13863
    Location:151247
    DUF4200; Domain of unknown function (DUF4200)
    cl00034
    Location:96139
    Bbox_SF; B-box-type zinc finger superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    27284886..27311272 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544453.1XP_011542755.1  E3 ubiquitin-protein ligase TRIM35 isoform X1

    See identical proteins and their annotated locations for XP_011542755.1

    Conserved Domains (2) summary
    pfam13863
    Location:197
    DUF4200; Domain of unknown function (DUF4200)
    cd12893
    Location:153332
    SPRY_PRY_TRIM35; PRY/SPRY domain in tripartite motif-containing protein 35 (TRIM35)
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