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PPRC1 PPARG related coactivator 1 [ Homo sapiens (human) ]

Gene ID: 23082, updated on 8-Jul-2021

Summary

Official Symbol
PPRC1provided by HGNC
Official Full Name
PPARG related coactivator 1provided by HGNC
Primary source
HGNC:HGNC:30025
See related
Ensembl:ENSG00000148840 MIM:617462
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRC
Summary
The protein encoded by this gene is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). This protein has been shown to interact with NRF1. It is thought to be a functional relative of PPAR-gamma coactivator 1 that activates mitochondrial biogenesis through NRF1 in response to proliferative signals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Expression
Ubiquitous expression in gall bladder (RPKM 7.9), appendix (RPKM 7.5) and 25 other tissues See more
Orthologs
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Genomic context

See PPRC1 in Genome Data Viewer
Location:
10q24.32
Exon count:
19
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (102120634..102150333)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (103892797..103910090)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene HPS6 biogenesis of lysosomal organelles complex 2 subunit 3 Neighboring gene LIM domain binding 1 Neighboring gene nucleolar and coiled-body phosphoprotein 1 Neighboring gene ELOVL fatty acid elongase 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0595, MGC74642, RP11-302K17.6

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables nuclear receptor coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in positive regulation of DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
peroxisome proliferator-activated receptor gamma coactivator-related protein 1
Names
PGC-1-related coactivator
peroxisome proliferator-activated receptor gamma, coactivator-related 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047132.1 RefSeqGene

    Range
    5047..22340
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001288727.2NP_001275656.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two exons in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AB011167, BU742486, HY023373
    Consensus CDS
    CCDS73186.1
    UniProtKB/Swiss-Prot
    Q5VV67
    UniProtKB/TrEMBL
    E7EVG6
    Related
    ENSP00000399743.2, ENST00000413464.6
    Conserved Domains (1) summary
    cd12624
    Location:12771367
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins
  2. NM_001288728.2NP_001275657.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001275657.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' coding region and initiates translation at an alternate start codon, which leads to a frameshift, compared to variant 1. The encoded isoform (3) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AB011167, AF325193, BC063806, BU742486, HY023373
    UniProtKB/Swiss-Prot
    Q5VV67
    Conserved Domains (1) summary
    cd12624
    Location:14191509
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins
  3. NM_015062.5NP_055877.3  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform 1

    See identical proteins and their annotated locations for NP_055877.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AB011167, BU742486, HY023373
    Consensus CDS
    CCDS7529.1
    UniProtKB/Swiss-Prot
    Q5VV67
    Related
    ENSP00000278070.2, ENST00000278070.7
    Conserved Domains (1) summary
    cd12624
    Location:15411631
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    102120634..102150333
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024447914.1XP_024303682.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X6

    Conserved Domains (2) summary
    cd12624
    Location:14621552
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins
    cl26464
    Location:5311123
    Atrophin-1; Atrophin-1 family
  2. XM_024447917.1XP_024303685.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X6

    Conserved Domains (2) summary
    cd12624
    Location:14621552
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins
    cl26464
    Location:5311123
    Atrophin-1; Atrophin-1 family
  3. XM_011539551.2XP_011537853.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X7

    Conserved Domains (1) summary
    cd12624
    Location:14581548
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins
  4. XM_017015982.1XP_016871471.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X1

  5. XM_017015984.1XP_016871473.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X8

  6. XM_011539549.2XP_011537851.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X3

    Conserved Domains (1) summary
    cd12624
    Location:14981588
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins
  7. XM_005269656.3XP_005269713.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X2

    Conserved Domains (1) summary
    cd12624
    Location:15231613
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins
  8. XM_011539552.2XP_011537854.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X9

    Conserved Domains (1) summary
    cd12624
    Location:12591349
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins
  9. XM_017015985.1XP_016871474.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X10

  10. XM_017015983.1XP_016871472.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X5

  11. XM_006717731.3XP_006717794.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X11

    Conserved Domains (1) summary
    PHA03247
    Location:6101136
    PHA03247; large tegument protein UL36; Provisional
  12. XM_024447913.1XP_024303681.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X4

    Conserved Domains (2) summary
    cd12624
    Location:14921582
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins
    cl26464
    Location:5611153
    Atrophin-1; Atrophin-1 family
  13. XM_024447915.1XP_024303683.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X6

    Conserved Domains (2) summary
    cd12624
    Location:14621552
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins
    cl26464
    Location:5311123
    Atrophin-1; Atrophin-1 family
  14. XM_024447916.1XP_024303684.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X6

    Conserved Domains (2) summary
    cd12624
    Location:14621552
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins
    cl26464
    Location:5311123
    Atrophin-1; Atrophin-1 family

RNA

  1. XR_001747067.1 RNA Sequence

  2. XR_001747068.1 RNA Sequence

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