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Pprc1 peroxisome proliferative activated receptor, gamma, coactivator-related 1 [ Mus musculus (house mouse) ]

Gene ID: 226169, updated on 26-Sep-2022

Summary

Official Symbol
Pprc1provided by MGI
Official Full Name
peroxisome proliferative activated receptor, gamma, coactivator-related 1provided by MGI
Primary source
MGI:MGI:2385096
See related
Ensembl:ENSMUSG00000055491 AllianceGenome:MGI:2385096
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PRC; mKIAA0595; A930018M19
Summary
Predicted to enable nuclear receptor coactivator activity. Predicted to be involved in positive regulation of DNA-binding transcription factor activity and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in central nervous system; early conceptus; limb; and sensory organ. Orthologous to human PPRC1 (PPARG related coactivator 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 14.9), ovary adult (RPKM 11.5) and 28 other tissues See more
Orthologs
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Genomic context

See Pprc1 in Genome Data Viewer
Location:
19; 19 C3
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (46044955..46061348)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (46056526..46072909)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930505N22 gene Neighboring gene HPS6, biogenesis of lysosomal organelles complex 2 subunit 3 Neighboring gene LIM domain binding 1 Neighboring gene ES cell cis-regulatory motif 2c Neighboring gene nucleolar and coiled-body phosphoprotein 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

General gene information

Markers

Homology

Clone Names

  • MGC12121

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclear receptor coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
 
enables transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in positive regulation of DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
peroxisome proliferator-activated receptor gamma coactivator-related protein 1
Names
PGC-1-related coactivator

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081214.1NP_001074683.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001074683.1

    Status: VALIDATED

    Source sequence(s)
    AC140233
    Consensus CDS
    CCDS38005.1
    UniProtKB/Swiss-Prot
    Q6NZN1, Q91YW8
    Related
    ENSMUSP00000107530.2, ENSMUST00000111899.8
    Conserved Domains (1) summary
    cd12624
    Location:15211611
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins
  2. NM_001346801.1NP_001333730.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC140233
    Consensus CDS
    CCDS89404.1
    UniProtKB/Swiss-Prot
    Q6NZN1
    Related
    ENSMUSP00000079389.4, ENSMUST00000062322.11

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    46044955..46061348
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527008.4XP_006527071.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X3

    Conserved Domains (2) summary
    PHA03247
    Location:5821120
    PHA03247; large tegument protein UL36; Provisional
    cd12624
    Location:15211611
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins
  2. XM_030250903.2XP_030106763.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X6

    Conserved Domains (2) summary
    PHA03247
    Location:9881383
    PHA03247; large tegument protein UL36; Provisional
    cd12624
    Location:15201610
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins
  3. XM_006527009.4XP_006527072.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X4

    Conserved Domains (2) summary
    PHA03247
    Location:5791117
    PHA03247; large tegument protein UL36; Provisional
    cd12624
    Location:15201610
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins
  4. XM_006527007.4XP_006527070.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X1

    Conserved Domains (2) summary
    PHA03247
    Location:5811119
    PHA03247; large tegument protein UL36; Provisional
    cd12624
    Location:15221612
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins
  5. XM_030250902.2XP_030106762.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X5

    Conserved Domains (2) summary
    PHA03247
    Location:5811119
    PHA03247; large tegument protein UL36; Provisional
    cd12624
    Location:15201610
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins
  6. XM_030250905.2XP_030106765.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X8

    Conserved Domains (2) summary
    PHA03247
    Location:9871382
    PHA03247; large tegument protein UL36; Provisional
    cd12624
    Location:15191609
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins
  7. XM_011247239.3XP_011245541.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X7

    Conserved Domains (2) summary
    PHA03247
    Location:5781116
    PHA03247; large tegument protein UL36; Provisional
    cd12624
    Location:15191609
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins
  8. XM_030250906.2XP_030106766.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X9

    Conserved Domains (2) summary
    PHA03247
    Location:9841379
    PHA03247; large tegument protein UL36; Provisional
    cd12624
    Location:15181608
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins
  9. XM_036161570.1XP_036017463.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X12

    Conserved Domains (2) summary
    PHA03247
    Location:9841379
    PHA03247; large tegument protein UL36; Provisional
    cd12624
    Location:15161606
    RRM_PRC; RNA recognition motif (RRM) found in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins
  10. XM_017318166.3XP_017173655.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q6NZN1
    Conserved Domains (2) summary
    PHA03247
    Location:9881383
    PHA03247; large tegument protein UL36; Provisional
    cd12624
    Location:15221612
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins
  11. XM_006527010.3XP_006527073.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X10

    Conserved Domains (2) summary
    PHA03247
    Location:5761114
    PHA03247; large tegument protein UL36; Provisional
    cd12624
    Location:15171607
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins
  12. XM_006527011.3XP_006527074.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X11

    Conserved Domains (2) summary
    PHA03247
    Location:5751113
    PHA03247; large tegument protein UL36; Provisional
    cd12624
    Location:15161606
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins
  13. XM_011247240.4XP_011245542.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X13

    Conserved Domains (2) summary
    PHA03247
    Location:5351073
    PHA03247; large tegument protein UL36; Provisional
    cd12624
    Location:14761566
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins
  14. XM_011247241.2XP_011245543.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X14

    Conserved Domains (2) summary
    PHA03247
    Location:4661004
    PHA03247; large tegument protein UL36; Provisional
    cd12624
    Location:14051495
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_145504.1: Suppressed sequence

    Description
    NM_145504.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.