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Wdtc1 WD and tetratricopeptide repeats 1 [ Mus musculus (house mouse) ]

Gene ID: 230796, updated on 6-Jun-2024

Summary

Official Symbol
Wdtc1provided by MGI
Official Full Name
WD and tetratricopeptide repeats 1provided by MGI
Primary source
MGI:MGI:2685541
See related
Ensembl:ENSMUSG00000037622 AllianceGenome:MGI:2685541
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
adp; Gm695; adipose
Summary
Enables enzyme inhibitor activity; histone binding activity; and histone deacetylase binding activity. Acts upstream of or within several processes, including cellular response to insulin stimulus; glucose metabolic process; and negative regulation of cellular biosynthetic process. Located in cytosol and nucleus. Is expressed in heart left ventricle; heart right ventricle; left lung; pancreas; and right lung. Orthologous to human WDTC1 (WD and tetratricopeptide repeats 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 115.3), duodenum adult (RPKM 49.0) and 24 other tissues See more
Orthologs
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Genomic context

See Wdtc1 in Genome Data Viewer
Location:
4 D2.3; 4 66.25 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (133019777..133080811, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (133292466..133353469, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene synaptotagmin-like 1 Neighboring gene STARR-seq mESC enhancer starr_11620 Neighboring gene transmembrane protein 222 Neighboring gene STARR-seq mESC enhancer starr_11622 Neighboring gene STARR-positive B cell enhancer mm9_chr4:132865900-132866201 Neighboring gene STARR-positive B cell enhancer ABC_E7995 Neighboring gene STARR-seq mESC enhancer starr_11626 Neighboring gene STARR-seq mESC enhancer starr_11627 Neighboring gene STARR-positive B cell enhancer ABC_E1657 Neighboring gene STARR-seq mESC enhancer starr_11628 Neighboring gene microRNA 5122 Neighboring gene solute carrier family 9 (sodium/hydrogen exchanger), member 1 Neighboring gene RIKEN cDNA 1700091J24 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables histone binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables histone deacetylase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of Cul4-RING E3 ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
WD and tetratricopeptide repeats protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001416526.1NP_001403455.1  WD and tetratricopeptide repeats protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL671882
    UniProtKB/Swiss-Prot
    Q80ZK9
    UniProtKB/TrEMBL
    A2AE98
  2. NM_001416528.1NP_001403457.1  WD and tetratricopeptide repeats protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL671882
    UniProtKB/Swiss-Prot
    Q80ZK9
    UniProtKB/TrEMBL
    A2AE98
  3. NM_001416529.1NP_001403458.1  WD and tetratricopeptide repeats protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL671882
    UniProtKB/TrEMBL
    A2AE98
  4. NM_001416531.1NP_001403460.1  WD and tetratricopeptide repeats protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL671882
    UniProtKB/TrEMBL
    A2AE98
  5. NM_001416532.1NP_001403461.1  WD and tetratricopeptide repeats protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL671882
    UniProtKB/TrEMBL
    A2AE98
  6. NM_001416533.1NP_001403462.1  WD and tetratricopeptide repeats protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL671882
  7. NM_001416534.1NP_001403463.1  WD and tetratricopeptide repeats protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL671882
  8. NM_199306.4NP_955010.1  WD and tetratricopeptide repeats protein 1 isoform 1

    See identical proteins and their annotated locations for NP_955010.1

    Status: VALIDATED

    Source sequence(s)
    AL671882
    Consensus CDS
    CCDS18746.1
    UniProtKB/Swiss-Prot
    Q80ZK9
    UniProtKB/TrEMBL
    A2AE98
    Related
    ENSMUSP00000040647.8, ENSMUST00000043305.14
    Conserved Domains (4) summary
    PLN03088
    Location:367437
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    sd00006
    Location:365389
    TPR; TPR repeat [structural motif]
    sd00039
    Location:5188
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:34163
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. NR_184161.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL671882
  2. NR_184162.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL671882

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    133019777..133080811 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)