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WDTC1 WD and tetratricopeptide repeats 1 [ Homo sapiens (human) ]

Gene ID: 23038, updated on 12-Oct-2019

Summary

Official Symbol
WDTC1provided by HGNC
Official Full Name
WD and tetratricopeptide repeats 1provided by HGNC
Primary source
HGNC:HGNC:29175
See related
Ensembl:ENSG00000142784
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ADP; DCAF9
Expression
Ubiquitous expression in testis (RPKM 28.2), heart (RPKM 14.1) and 25 other tissues See more
Orthologs

Genomic context

See WDTC1 in Genome Data Viewer
Location:
1p36.11
Exon count:
19
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (27234613..27308636)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (27561007..27635124)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene small nuclear ribonucleoprotein polypeptide E pseudogene 7 Neighboring gene uncharacterized LOC105376890 Neighboring gene actin gamma 1 pseudogene 20 Neighboring gene transmembrane protein 222 Neighboring gene RNA, U6 small nuclear 48, pseudogene Neighboring gene synaptotagmin like 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of WD and tetratricopeptide repeats 1 (WDTC1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1037

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enzyme inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
histone binding IEA
Inferred from Electronic Annotation
more info
 
histone deacetylase binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular chemical homeostasis IEA
Inferred from Electronic Annotation
more info
 
cellular response to insulin stimulus IEA
Inferred from Electronic Annotation
more info
 
glucose metabolic process IEA
Inferred from Electronic Annotation
more info
 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
negative regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
regulation of cell size IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
WD and tetratricopeptide repeats protein 1
Names
DDB1 and CUL4 associated factor 9
adipose homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276252.2NP_001263181.1  WD and tetratricopeptide repeats protein 1 isoform a

    See identical proteins and their annotated locations for NP_001263181.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK315564, BC032523, DB072151, FO393419, HY218382
    Consensus CDS
    CCDS60044.1
    UniProtKB/Swiss-Prot
    Q8N5D0
    Related
    ENSP00000317971.3, ENST00000319394.8
    Conserved Domains (4) summary
    sd00006
    Location:366390
    TPR; TPR repeat [structural motif]
    sd00039
    Location:5188
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:34163
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl26005
    Location:368438
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
  2. NM_015023.5NP_055838.2  WD and tetratricopeptide repeats protein 1 isoform b

    See identical proteins and their annotated locations for NP_055838.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (b) that is 1 aa shorter than isoform a.
    Source sequence(s)
    BC032523, DB072151, FO393419, HY218382
    Consensus CDS
    CCDS296.1
    UniProtKB/Swiss-Prot
    Q8N5D0
    Related
    ENSP00000355317.3, ENST00000361771.7
    Conserved Domains (4) summary
    sd00006
    Location:365389
    TPR; TPR repeat [structural motif]
    sd00039
    Location:5188
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:34163
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl26005
    Location:367437
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    27234613..27308636
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541058.3XP_011539360.1  WD and tetratricopeptide repeats protein 1 isoform X2

    Conserved Domains (7) summary
    COG2319
    Location:41329
    WD40; WD40 repeat [General function prediction only]
    sd00006
    Location:366390
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:396430
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:366430
    TPR_11; TPR repeat
    pfam13432
    Location:402467
    TPR_16; Tetratricopeptide repeat
    sd00039
    Location:5188
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:34163
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_017000730.2XP_016856219.1  WD and tetratricopeptide repeats protein 1 isoform X3

  3. XM_011541057.1XP_011539359.1  WD and tetratricopeptide repeats protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011539359.1

    UniProtKB/Swiss-Prot
    Q8N5D0
    Related
    ENSP00000434578.1, ENST00000447062.2
    Conserved Domains (4) summary
    sd00006
    Location:366390
    TPR; TPR repeat [structural motif]
    sd00039
    Location:5188
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:34163
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl26005
    Location:368438
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
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